Drug Information

Drug (ID: DG02144) and It's Reported Resistant Information

Name	Gemcitabine/Huaier
Synonyms	Gemcitabine/Huaier Click to Show/Hide
Indication	In total 1 Indication(s) . . . [1]

Type(s) of Resistant Mechanism of This Drug

ADTT: Aberration of the Drug's Therapeutic Target

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-02: Benign/in-situ/malignant neoplasm

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Pancreatic cancer [ICD-11: 2C10]

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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
Aberration of the Drug's Therapeutic Target (ADTT)		Click to Show/Hide
Key Molecule: Forkhead box protein M1 (FOXM1)			[1]
Sensitive Disease	Pancreatic ductal adenocarcinoma [ICD-11: 2C10.0]		Disease Info
Molecule Alteration	Expressiom	Up-regulation	Molecule Info
Experimental Note	Discovered Using In-vivo Testing Model
In Vivo Model	nude mice injected Panc-1 cells		Mus musculus
Experiment for Drug Resistance	Tumor evaluation assay
Mechanism Description	Overall, this study illustrates that Huaier augments the tumor-killing effect of gemcitabine through suppressing the stemness induced by gemcitabine in a FoxM1-dependent way. These results indicate that Huaier can be applied to overcome gemcitabine resistance.

References

Ref 1	Huaier enhances the tumor-killing effect and reverses gemcitabine-induced stemness by suppressing FoxM1. Phytomedicine. 2024 Jul;129:155656.

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