Drug Information

Drug (ID: DG02043) and It's Reported Resistant Information

Name	IgG isotype
Indication	In total 1 Indication(s) . . .
Drug Resistance Disease(s)	Disease(s) with Resistance Information Discovered by Cell Line Test for This Drug (1 diseases) Liver cancer [ICD-11: 2C12] [1]

Type(s) of Resistant Mechanism of This Drug

MRAP: Metabolic Reprogramming via Altered Pathways

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-02: Benign/in-situ/malignant neoplasm

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Liver cancer [ICD-11: 2C12]

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Metabolic Reprogramming via Altered Pathways (MRAP)		Click to Show/Hide
Key Molecule: Histone H3			[1]
Metabolic Type	Glucose metabolism
Resistant Disease	Hepatocellular carcinoma [ICD-11: 2C12.02]		Disease Info
Molecule Alteration	Lactylation	H3K18la	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vivo Model	Immunocompetent mice inoculated with control Hepa1-6 cells		Mice
Experiment for Molecule Alteration	Western blot analysis
Experiment for Drug Resistance	Tumor volume assay
Mechanism Description	SRSF10 was upregulated in various tumors and associated with poor prognosis. Moreover, SRSF10 positively regulated lactate production, and SRSF10/glycolysis/ histone H3 lysine 18 lactylation (H3K18la) formed a positive feedback loop in tumor cells. Increased lactate levels promoted M2 macrophage polarization, thereby inhibiting CD8 T cell activity.

Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
Metabolic Reprogramming via Altered Pathways (MRAP)		Click to Show/Hide
Key Molecule: Histone H3			[1]
Metabolic Type	Glucose metabolism
Sensitive Disease	Hepatocellular carcinoma [ICD-11: 2C12.02]		Disease Info
Molecule Alteration	Lactylation	H3K18la	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vivo Model	Immunocompetent mice inoculated with shSrsf10 cells		Mice
Experiment for Molecule Alteration	Western blot analysis
Experiment for Drug Resistance	Tumor volume assay
Mechanism Description	SRSF10 was upregulated in various tumors and associated with poor prognosis. Moreover, SRSF10 positively regulated lactate production, and SRSF10/glycolysis/ histone H3 lysine 18 lactylation (H3K18la) formed a positive feedback loop in tumor cells. Increased lactate levels promoted M2 macrophage polarization, thereby inhibiting CD8 T cell activity.

References

Ref 1	Targeting SRSF10 might inhibit M2 macrophage polarization and potentiate anti-PD-1 therapy in hepatocellular carcinoma. Cancer Commun (Lond). 2024 Nov;44(11):1231-1260.