Drug Information

Drug (ID: DG02041) and It's Reported Resistant Information

Name	Anti-isotype IgG mAb
Indication	In total 1 Indication(s) . . .
Drug Resistance Disease(s)	Disease(s) with Resistance Information Discovered by Cell Line Test for This Drug (1 diseases) Lung cancer [ICD-11: 2C25] [1]

Type(s) of Resistant Mechanism of This Drug

MRAP: Metabolic Reprogramming via Altered Pathways

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-02: Benign/in-situ/malignant neoplasm

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Lung cancer [ICD-11: 2C25]

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Metabolic Reprogramming via Altered Pathways (MRAP)		Click to Show/Hide
Key Molecule: Apolipoprotein C-II (APOC2)			[1]
Metabolic Type	Glucose metabolism
Resistant Disease	Non-small cell lung carcinoma [ICD-11: 2C25.Y]		Disease Info
Molecule Alteration	Lactylation	K70	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vivo Model	Flag-tagged APOC2-K70R mice		Mice
Experiment for Molecule Alteration	Mass spectrometry analysis
Experiment for Drug Resistance	Tumor growth assay
Mechanism Description	Mechanistically, lactate enhances APOC2 lactylation at K70, stabilizing it and resulting in FFA release, regulatory T cell accumulation, immunotherapy resistance, and metastasis.

Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
Metabolic Reprogramming via Altered Pathways (MRAP)		Click to Show/Hide
Key Molecule: Apolipoprotein C-II (APOC2)			[1]
Metabolic Type	Glucose metabolism
Sensitive Disease	Non-small cell lung carcinoma [ICD-11: 2C25.Y]		Disease Info
Molecule Alteration	Lactylation	K70	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vivo Model	Flag-tagged APOC2-WT mice		Mice
Experiment for Molecule Alteration	Mass spectrometry analysis
Experiment for Drug Resistance	Tumor growth assay
Mechanism Description	Mechanistically, lactate enhances APOC2 lactylation at K70, stabilizing it and resulting in FFA release, regulatory T cell accumulation, immunotherapy resistance, and metastasis.

References

Ref 1	Lactylated Apolipoprotein C-II Induces Immunotherapy Resistance by Promoting Extracellular Lipolysis. Adv Sci (Weinh). 2024 Oct;11(38):e2406333.