Drug Information

Drug (ID: DG02011) and It's Reported Resistant Information

• Name: Folate-polySia
• Indication:
  In total 1 Indication(s)
  . .; .

Type(s) of Resistant Mechanism of This Drug

  MRAP: Metabolic Reprogramming via Altered Pathways

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-02: Benign/in-situ/malignant neoplasm

Cervical cancer [ICD-11: 2C77]

Drug Sensitivity Data Categorized by Their Corresponding Mechanisms

Metabolic Reprogramming via Altered Pathways (MRAP)

Key Molecule: CD36 molecule (CD36) [1]

• Metabolic Type: Lipid metabolism
• Sensitive Disease: Cervical cancer [ICD-11: 2C77.0]
• Molecule Alteration: Expression; Up-regulation
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: HeLa/DDP cells; Uterus; Homo sapiens (Human); CVCL_C869
• In Vitro Model: MCF/ADR cells; Cervix; Homo sapiens (Human); CVCL_0031
• Experiment for Molecule Alteration: qRT-PCR
• Experiment for Drug Resistance: Apoptosis rate assay
• Mechanism Description: The main reason was that FpSA promoted cancer cells to switch from fatty acid metabolism to glycolysis and alleviate resistance to cisplatin.

Key Molecule: CD36 molecule (CD36) [1]

• Metabolic Type: Lipid metabolism
• Sensitive Disease: Cervical cancer [ICD-11: 2C77.0]
• Molecule Alteration: Expression; Up-regulation
• Experimental Note: Revealed Based on the Cell Line Data
• In Vivo Model: Nude mice, HeLa/DDP cells; Mice
• Experiment for Molecule Alteration: qRT-PCR
• Experiment for Drug Resistance: Tumor volume assay; Tumor weight assay
• Mechanism Description: The main reason was that FpSA promoted cancer cells to switch from fatty acid metabolism to glycolysis and alleviate resistance to cisplatin.

References

• Ref 1: Cell calcification reverses the chemoresistance of cancer cells via the conversion of glycolipid metabolism. Biomaterials. 2025 Mar;314:122886.