Drug Information

Drug (ID: DG02009) and It's Reported Resistant Information

• Name: 27-Hydroxycholesterol
• Synonyms: 27-OHC; 26-hydroxycholesterol
• Indication:
  In total 1 Indication(s)
  Discovery agent [ICD-11: N.A.]; Investigative
• Drug Resistance Disease(s):
  Disease(s) with Resistance Information Discovered by Cell Line Test for This Drug (1 diseases)
  Liver cancer [ICD-11: 2C12]; [1]
• Target: Oxysterols receptor LXR-beta (NR1H2); NR1H2_HUMAN
• Formula: 40.5
• IsoSMILES: FYHRJWMENCALJY-YSQMORBQSA-N
• InChI: C[C@H](CCC[C@@H](C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C)CO
• InChIKey: (3S,8S,9S,10R,13R,14S,17R)-17-[(2R,6R)-7-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
• PubChem CID: 123976
• TTD Drug ID: D0H2YM

Type(s) of Resistant Mechanism of This Drug

  MRAP: Metabolic Reprogramming via Altered Pathways

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-02: Benign/in-situ/malignant neoplasm

Liver cancer [ICD-11: 2C12]

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Metabolic Reprogramming via Altered Pathways (MRAP)

Key Molecule: Glucose-regulated protein 75 (GRP75) [1]

• Metabolic Type: Redox metabolism
• Resistant Disease: Hepatocellular carcinoma [ICD-11: 2C12.02]
• Molecule Alteration: Activity; activation
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: HepG2 cells; Liver; Homo sapiens (Human); CVCL_0027
• Experiment for Molecule Alteration: Western blot analysis
• Experiment for Drug Resistance: Cell viability assay
• Mechanism Description: we found that by inducing an increase in oxidative stress signalling, 27HC activated glucose-regulated protein 75 (GRP75).

Key Molecule: Glucose-regulated protein 75 (GRP75) [1]

• Metabolic Type: Redox metabolism
• Resistant Disease: Hepatocellular carcinoma [ICD-11: 2C12.02]
• Molecule Alteration: Activity; activation
• Experimental Note: Revealed Based on the Cell Line Data
• In Vivo Model: HepG2 cells, BALB/c nude mice; Mice
• Experiment for Molecule Alteration: Western blot analysis
• Experiment for Drug Resistance: Tumor volume assay
• Mechanism Description: we found that by inducing an increase in oxidative stress signalling, 27HC activated glucose-regulated protein 75 (GRP75).

References

• Ref 1: 27-Hydroxycholesterol is a specific factor in the neoplastic microenvironment of HCC that causes MDR via GRP75 regulation of the redox balance and metabolic reprogramming. Cell Biol Toxicol. 2022 Apr;38(2):311-324.