Drug Information

Drug (ID: DG01882) and It's Reported Resistant Information

• Name: IDH1 inhibitors
• Synonyms: IDH1 inhibitors
• Target: .; NOUNIPROTAC; [1]

Type(s) of Resistant Mechanism of This Drug

  ADTT: Aberration of the Drug's Therapeutic Target

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-02: Benign/in-situ/malignant neoplasm

Brain cancer [ICD-11: 2A00]

Drug Sensitivity Data Categorized by Their Corresponding Mechanisms

Aberration of the Drug's Therapeutic Target (ADTT)

Key Molecule: Oxalosuccinate decarboxylase (IDH1) [1]

• Molecule Alteration: Missense mutation; p.R132H (c.395G>A)
• Sensitive Disease: Brain glioma [ICD-11: 2A00.0]
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: TS676 cells; Brain; Homo sapiens (Human); CVCL_A5HX
• In Vitro Model: TS603 cells; Brain; Homo sapiens (Human); CVCL_A5HW
• In Vitro Model: TS516 cells; Brain; Homo sapiens (Human); CVCL_A5HY
• In Vivo Model: SCID mouse xenograft model; Mus musculus
• Experiment for Drug Resistance: Soft agar assay
• Mechanism Description: The missense mutation p.R132H (c.395G>A) in gene IDH1 cause the sensitivity of IDH1 inhibitors by aberration of the drug's therapeutic target

References

• Ref 1: An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cellsScience. 2013 May 3;340(6132):626-30. doi: 10.1126/science.1236062. Epub 2013 Apr 4.