Drug Information

Drug (ID: DG01874) and It's Reported Resistant Information

• Name: YM-024
• Synonyms: YM-024
• Target: .; NOUNIPROTAC; [1]

Type(s) of Resistant Mechanism of This Drug

  UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-02: Benign/in-situ/malignant neoplasm

Brain cancer [ICD-11: 2A00]

Drug Sensitivity Data Categorized by Their Corresponding Mechanisms

Unusual Activation of Pro-survival Pathway (UAPP)

Key Molecule: PI3-kinase alpha (PIK3CA) [1]

• Molecule Alteration: Missense mutation; p.H1047Y (c.3139C>T)
• Sensitive Disease: FGFR-tacc positive glioblastoma [ICD-11: 2A00.01]
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: SK-MG-26 cell; N.A.; Homo sapiens (Human); CVCL_D701
• In Vitro Model: SK-MG-17 cells; N.A.; Homo sapiens (Human); CVCL_8574
• Experiment for Molecule Alteration: Western blotting analysis
• Experiment for Drug Resistance: CellTiter96 AQueous assay; Soft-agar colony formation assay

References

• Ref 1: Targeting class IA PI3K isoforms selectively impairs cell growth, survival, and migration in glioblastomaPLoS One. 2014 Apr 9;9(4):e94132. doi: 10.1371/journal.pone.0094132. eCollection 2014.