Drug Information

Drug (ID: DG01866) and It's Reported Resistant Information

• Name: Compound 3144
• Synonyms: Compound 3144
• Target: .; NOUNIPROTAC; [1]

Type(s) of Resistant Mechanism of This Drug

  UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-02: Benign/in-situ/malignant neoplasm

Mature T-cell lymphoma [ICD-11: 2A90]

Drug Sensitivity Data Categorized by Their Corresponding Mechanisms

Unusual Activation of Pro-survival Pathway (UAPP)

Key Molecule: GTPase Nras (NRAS) [1]

• Molecule Alteration: Missense mutation; p.G13D (c.38G>A)
• Sensitive Disease: T-cell lymphoma [ICD-11: 2A60.3]
• Experimental Note: Revealed Based on the Cell Line Data
• Cell Pathway Regulation: RAS signaling pathway; Inhibition; hsa04014
• In Vitro Model: MEF cells; Bone marrow; Homo sapiens (Human); CVCL_M515
• In Vivo Model: Athymic nude Nu/Nu mouse PDX model; Mus musculus

References

• Ref 1: Multivalent Small-Molecule Pan-RAS InhibitorsCell. 2017 Feb 23;168(5):878-889.e29. doi: 10.1016/j.cell.2017.02.006.