Drug Information

Drug (ID: DG01848) and It's Reported Resistant Information

• Name: Interferon alfa-2B
• Synonyms: INTERFERON ALFA-2B; 98530-12-2; Interferon alfa-2b, recombinant; C16H17Cl3I2N3NaO5S; SCHEMBL6041041; K779; Q4391540
• Indication:
  In total 1 Indication(s)
  Melanoma [ICD-11: 2C30]; Approved; [1]
• Drug Resistance Disease(s):
  Disease(s) with Clinically Reported Resistance for This Drug (1 diseases)
  Head and neck cancer [ICD-11: 2D42]; [1]
• Target: Interferon-alpha 2 (IFNA2); IFNA2_HUMAN; [1]
• Formula: 7
• IsoSMILES: CCCN(CCOC1=C(C=C(C=C1Cl)Cl)Cl)C(=O)N2C=CN=C2.C(S(=O)(=O)[O-])(I)I.[Na+]
• InChI: InChI=1S/C15H16Cl3N3O2.CH2I2O3S.Na/c1-2-4-20(15(22)21-5-3-19-10-21)6-7-23-14-12(17)8-11(16)9-13(14)18;2-1(3)7(4,5)6;/h3,5,8-10H,2,4,6-7H2,1H3;1H,(H,4,5,6);/q;;+1/p-1
• InChIKey: MIXCUJKCXRNYFM-UHFFFAOYSA-M
• PubChem CID: 71306834
• TTD Drug ID: D0P0WV
• DrugBank ID: DB05258

Type(s) of Resistant Mechanism of This Drug

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-02: Benign/in-situ/malignant neoplasm

Head and neck cancer [ICD-11: 2D42]

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Key Molecule: MX dynamin like GTPase 1 (MX1) [1]

• Molecule Alteration: Up-regulation; Interaction
• Resistant Disease: Head and neck squamous cell carcinoma [ICD-11: 2D42.1]
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: HN30 cells; Nasopharyngeal; Homo sapiens (Human); CVCL_5525
• In Vitro Model: HN4 cells; Nasopharyngeal; Homo sapiens (Human); CVCL_IS30
• In Vitro Model: HN6 cells; Tongue; Homo sapiens (Human); CVCL_8129
• In Vivo Model: BALB/c nude mice model; Mus musculus
• Experiment for Molecule Alteration: Overexpression assay
• Experiment for Drug Resistance: Flow cytometry assay
• Mechanism Description: LncMX1-215 negatively regulates immunosuppression by interrupting GCN5/H3K27ac binding in HNSCC.

References

• Ref 1: A novel IFNAlpha-induced long noncoding RNA negatively regulates immunosuppression by interrupting H3K27 acetylation in head and neck squamous cell carcinomaMol Cancer. 2020 Jan 6;19(1):4. doi: 10.1186/s12943-019-1123-y.