Drug Information

Drug (ID: DG01809) and It's Reported Resistant Information

• Name: Succinate
• Synonyms: Succinate; Butanedioate; Succinate dianion; Butanedioic acid, ion(2-); 56-14-4; UNII-AJ326AG789; AJ326AG789; succ; monosuccinate; Butanedioate(2-); Succinate ion; succinate(2-); Succinate ion(2-); suc; Succinic acid, ion(2-); DTXSID4036772; CHEBI:30031; ANION STANDARD - SUCCINATE; STL302037; (-)OOC-CH2-CH2-COO(-); AKOS022140212; A802155; Q27104100
• Drug Resistance Disease(s):
  Disease(s) with Clinically Reported Resistance for This Drug (1 diseases)
  Oral squamous cell carcinoma [ICD-11: 2B6E]; [1]
• Target: .; NOUNIPROTAC; [1]
• Formula: 1
• IsoSMILES: C(CC(=O)[O-])C(=O)[O-]
• InChI: InChI=1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)/p-2
• InChIKey: KDYFGRWQOYBRFD-UHFFFAOYSA-L
• PubChem CID: 160419
• INTEDE ID: DR01246

Type(s) of Resistant Mechanism of This Drug

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-02: Benign/in-situ/malignant neoplasm

Oral squamous cell carcinoma [ICD-11: 2B6E]

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Key Molecule: Maternally expressed 3 (MEG3) [1]

• Molecule Alteration: .; Expression
• Resistant Disease: Oral squamous cell carcinoma [ICD-11: 2B6E.0]
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: CAL-27 cells; Tongue; Homo sapiens (Human); CVCL_1107
• In Vitro Model: OLP type I keratinocytes; N.A.; .; N.A.
• Experiment for Drug Resistance: Cell Titer-Glo assay; IC50 assay
• Mechanism Description: The critical roles of succinate and MEG3 in the metabolic changes during malignant transformation from OLP to OSCC.

References

• Ref 1: LncRNA MEG3 contributes to adenosine-induced cytotoxicity in hepatoma HepG2 cells by downregulated ILF3 and autophagy inhibition via regulation PI3K-AKT-mTOR and beclin-1 signaling pathwayJ Cell Biochem. 2019 Oct;120(10):18172-18185. doi: 10.1002/jcb.29123. Epub 2019 May 29.