Drug Information

Drug (ID: DG01701) and It's Reported Resistant Information

Name	BRAF/MEK inhibitors
Synonyms	BRAF/MEK inhibitors Click to Show/Hide
Drug Resistance Disease(s)	Disease(s) with Clinically Reported Resistance for This Drug (1 diseases) Melanoma [ICD-11: 2C30] [1]

Type(s) of Resistant Mechanism of This Drug

ADTT: Aberration of the Drug's Therapeutic Target

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-02: Benign/in-situ/malignant neoplasm

Click to Show/Hide the Resistance Disease of This Class

Melanoma [ICD-11: 2C30]

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Aberration of the Drug's Therapeutic Target (ADTT)			Click to Show/Hide
Key Molecule: MAPK/ERK kinase 2 (MEK2)				[1]
Resistant Disease	Melanoma [ICD-11: 2C30.0]			Disease Info
Molecule Alteration	Missense mutation		p.Q60P (c.179A>C)	Molecule Info
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	A375 cells	Skin	Homo sapiens (Human)	CVCL_0132
Experiment for Molecule Alteration	Western blot analysis
Experiment for Drug Resistance	CellTiter96 AQueous assay

References

Ref 1	MAP kinase pathway alterations in BRAF-mutant melanoma patients with acquired resistance to combined RAF/MEK inhibitionCancer Discov. 2014 Jan;4(1):61-8. doi: 10.1158/2159-8290.CD-13-0631. Epub 2013 Nov 21.

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