Drug Information

Drug (ID: DG01697) and It's Reported Resistant Information

Name	PD-0325901/Pictilisib
Synonyms	PD-0325901/Pictilisib Click to Show/Hide

Type(s) of Resistant Mechanism of This Drug

ADTT: Aberration of the Drug's Therapeutic Target

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-02: Benign/in-situ/malignant neoplasm

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Colorectal cancer [ICD-11: 2B91]

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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
Aberration of the Drug's Therapeutic Target (ADTT)			Click to Show/Hide
Key Molecule: PI3-kinase alpha (PIK3CA)				[1]
Sensitive Disease	Colorectal cancer [ICD-11: 2B91.1]			Disease Info
Molecule Alteration	Missense mutation		p.E542K (c.1624G>A)	Molecule Info
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	HT29 Cells	Colon	Homo sapiens (Human)	CVCL_A8EZ
	HCT116 cells	Colon	Homo sapiens (Human)	CVCL_0291
In Vivo Model	Female athymic CD1 mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	Western blot analysis
Experiment for Drug Resistance	Tumor volume measurement assay

References

Ref 1	The enhanced in vivo activity of the combination of a MEK and a PI3K inhibitor correlates with [18F]-FLT PET in human colorectal cancer xenograft tumour-bearing micePLoS One. 2013 Dec 10;8(12):e81763. doi: 10.1371/journal.pone.0081763. eCollection 2013.

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