Drug Information

Drug (ID: DG01672) and It's Reported Resistant Information
Name
Folfox protocol
Synonyms
Folfox protocol; Folfox regimen; FOLFOX-4 protocol; FOLFOX-6 protocol; FOLFOX-7 protocol; Folfox; FOLFOX-4; FOLFOX-6; FOLFOX-7; C410216000; Fluorouracil regimen with leucovorin calcium and oxaliplatin
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Structure
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Formula
9
IsoSMILES
[CH2-][C@@H]1CCCC[C@H]1[CH2-].C1C(N(C2=C(N1)N=C(NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O.C1=C(C(=O)NC(=O)N1)F.C(=O)(C(=O)O)O.[Pt+2]
InChI
InChI=1S/C20H23N7O7.C8H14.C4H3FN2O2.C2H2O4.Pt/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;1-7-5-3-4-6-8(7)2;5-2-1-6-4(9)7-3(2)8;3-1(4)2(5)6;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);7-8H,1-6H2;1H,(H2,6,7,8,9);(H,3,4)(H,5,6);/q;-2;;;+2/t12 ,13-;7-,8-;;;/m01.../s1
InChIKey
YXTKHLHCVFUPPT-YYFJYKOTSA-N
PubChem CID
135659064
Type(s) of Resistant Mechanism of This Drug
  DISM: Drug Inactivation by Structure Modification
Drug Resistance Data Categorized by Their Corresponding Diseases
ICD-02: Benign/in-situ/malignant neoplasm
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Colorectal cancer [ICD-11: 2B91]
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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
  Drug Inactivation by Structure Modification (DISM) Click to Show/Hide
Key Molecule: Glutathione S-transferase P (GSTP1) [1]
Sensitive Disease Colorectal cancer [ICD-11: 2B91.1]
 Disease Info 
Molecule Alteration Missense mutation
p.I105V (c.313A>G)
 Molecule Info 
Wild Type Structure Method: X-ray diffraction Resolution: 1.40  Å
PDB: 2A2R
Mutant Type Structure Method: X-ray diffraction Resolution: 1.80  Å
PDB: 1PGT
   Download The Information of Sequence       Download The Structure File   
RMSD: 0.32
TM score: 0.99645
Amino acid change:
I105V
 : Wild Type Structure
 : Mutant Type Structure
  Mutation site(s) have been marked in red
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G
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30
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40
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60
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90
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110
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120
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130
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140
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160
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170
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210
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Click to Show/Hide the Structure
Experimental Note Identified from the Human Clinical Data
In Vitro Model Human colorectal carcinoma tissue N.A.
Mechanism Description The missense mutation p.I105V (c.313A>G) in gene GSTP1 cause the sensitivity of Folfox Protocol by drug inactivation by structure modification
References
Ref 1 Influence of GSTP1 I105V polymorphism on cumulative neuropathy and outcome of FOLFOX-4 treatment in Asian patients with colorectal carcinomaCancer Sci. 2010 Feb;101(2):530-5. doi: 10.1111/j.1349-7006.2009.01418.x. Epub 2009 Oct 28.

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