Drug Information

Drug (ID: DG01638) and It's Reported Resistant Information

• Name: Ropeginterferon alfa-2b
• Synonyms: Ropeginterferon-alfa-2b; SCHEMBL23594684
• Indication:
  In total 1 Indication(s)
  Discovery agent [ICD-11: N.A.]; Phase 3; [1]
• Target: Fms-like tyrosine kinase 3 (FLT-3); FLT3_HUMAN; [1]
• Target: Tyrosine-protein kinase Mer (MERTK); MERTK_HUMAN; [1]
• Formula: 18
• IsoSMILES: COCCOC(=O)NCCCCC(CCN1CCC[C@H]1C(=O)O)NC(=O)OCCOC
• InChI: InChI=1S/C20H37N3O8/c1-28-12-14-30-19(26)21-9-4-3-6-16(22-20(27)31-15-13-29-2)8-11-23-10-5-7-17(23)18(24)25/h16-17H,3-15H2,1-2H3,(H,21,26)(H,22,27)(H,24,25)/t16 ,17-/m0/s1
• InChIKey: LICFWYDUJZDCLK-DJNXLDHESA-N
• PubChem CID: 86278347
• TTD Drug ID: D0N3XP
• DrugBank ID: DB15119

Type(s) of Resistant Mechanism of This Drug

  UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-02: Benign/in-situ/malignant neoplasm

Chronic myeloid leukemia [ICD-11: 2A20]

Drug Sensitivity Data Categorized by Their Corresponding Mechanisms

Unusual Activation of Pro-survival Pathway (UAPP)

Key Molecule: Tyrosine-protein kinase JAK2 (JAK3) [1]

• Molecule Alteration: Missense mutation; p.V617F (c.1849G>T)
• Sensitive Disease: Chronic myeloid leukemia [ICD-11: 2A20.0]
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: HEL cells; Blood; Homo sapiens (Human); CVCL_0001
• In Vitro Model: UKE-1 cells; Peripheral blood; Homo sapiens (Human); CVCL_0104
• Experiment for Drug Resistance: Trypan blue staining assay

Myeloproliferative neoplasm [ICD-11: 2A22]

Drug Sensitivity Data Categorized by Their Corresponding Mechanisms

Unusual Activation of Pro-survival Pathway (UAPP)

Key Molecule: Tyrosine-protein kinase JAK2 (JAK3) [1]

• Molecule Alteration: Missense mutation; p.V617F (c.1849G>T)
• Sensitive Disease: Myeloproliferative neoplasm [ICD-11: 2A22.0]
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: HEL cells; Blood; Homo sapiens (Human); CVCL_0001
• In Vitro Model: UKE-1 cells; Peripheral blood; Homo sapiens (Human); CVCL_0104
• Experiment for Drug Resistance: Trypan blue staining assay

References

• Ref 1: Ropeginterferon alpha-2b targets JAK2V617F-positive polycythemia vera cells in vitro and in vivoBlood Cancer J. 2018 Oct 4;8(10):94. doi: 10.1038/s41408-018-0133-0.