Drug Information

Drug (ID: DG00246) and It's Reported Resistant Information

Name	Elvitegravir
Synonyms	EVG Click to Show/Hide
Indication	In total 1 Indication(s) Human immunodeficiency virus disease [ICD-11: 1C60-1C62] Approved [1]
Structure
Drug Resistance Disease(s)	Disease(s) with Clinically Reported Resistance for This Drug (1 diseases) HIV infection [ICD-11: 1C62] [2] *Disease(s) with Resistance Information Validated by in-vivo* Model for This Drug** (1 diseases) HIV infection [ICD-11: 1C62] [3]
Target	Human immunodeficiency virus Integrase (HIV IN)	POL_HV1B1	[1]
Click to Show/Hide the Molecular Information and External Link(s) of This Drug
Formula	C23H23ClFNO5
IsoSMILES	CC(C)[C@@H](CO)N1C=C(C(=O)C2=C1C=C(C(=C2)CC3=C(C(=CC=C3)Cl)F)OC)C(=O)O
InChI	1S/C23H23ClFNO5/c1-12(2)19(11-27)26-10-16(23(29)30)22(28)15-8-14(20(31-3)9-18(15)26)7-13-5-4-6-17(24)21(13)25/h4-6,8-10,12,19,27H,7,11H2,1-3H3,(H,29,30)/t19-/m1/s1
InChIKey	JUZYLCPPVHEVSV-LJQANCHMSA-N
PubChem CID	5277135
ChEBI ID	CHEBI:72289
TTD Drug ID	D0QD1G
INTEDE ID	DR0570
DrugBank ID	DB09101

Type(s) of Resistant Mechanism of This Drug

ADTT: Aberration of the Drug's Therapeutic Target

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-01: Infectious/parasitic diseases

Click to Show/Hide the Resistance Disease of This Class

HIV infection [ICD-11: 1C62]

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Aberration of the Drug's Therapeutic Target (ADTT)			Click to Show/Hide
Key Molecule: HIV1 Integrase (HIV1 IT)				[4]
Molecule Alteration	Missense mutation		p.S17N+p.V32I+p.I36V+p.D41G+p.M50L+p.I72V+p.L101I+p.T124N+p.T125A+p.I135V+p.V201I+p.I208L+p.D256E	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	PCR; DNA sequencing assay
Experiment for Drug Resistance	PhenoSense assay
Mechanism Description	Q148N, a novel integrase inhibitor resistance mutation associated with low-level reduction in elvitegravir susceptibility.
Key Molecule: HIV1 Integrase (HIV1 IT)				[4]
Molecule Alteration	Missense mutation		p.S17N+p.V32I+p.I36V+p.D41G+p.M50L+p.I72V+p.L101I+p.T124N+p.T125A+p.I135V+p.Q148N+p.V201I+p.I208L+p.D256E	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	PCR; DNA sequencing assay
Experiment for Drug Resistance	PhenoSense assay
Mechanism Description	Q148N, a novel integrase inhibitor resistance mutation associated with low-level reduction in elvitegravir susceptibility.
Key Molecule: HIV1 Integrase (HIV1 IT)				[4]
Molecule Alteration	Missense mutation		p.S17N+p.V32I+p.I36V+p.D41G+p.M50L+p.I72V+p.L101I+p.T124N+p.T125A+p.I135V+p.G140S+p.Q148N+p.V201I+p.I208L+p.D256E	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	PCR; DNA sequencing assay
Experiment for Drug Resistance	PhenoSense assay
Mechanism Description	Q148N, a novel integrase inhibitor resistance mutation associated with low-level reduction in elvitegravir susceptibility.
Key Molecule: HIV1 Integrase (HIV1 IT)				[4]
Molecule Alteration	Missense mutation		p.I72V+p.I113V+p.Q148H+p.V151I+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	PCR; DNA sequencing assay
Experiment for Drug Resistance	PhenoSense assay
Mechanism Description	Q148N, a novel integrase inhibitor resistance mutation associated with low-level reduction in elvitegravir susceptibility.
Key Molecule: HIV1 Integrase (HIV1 IT)				[4]
Molecule Alteration	Missense mutation		p.I72V+p.I113V+p.G140S+p.Q148N+p.V151I+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	PCR; DNA sequencing assay
Experiment for Drug Resistance	PhenoSense assay
Mechanism Description	Q148N, a novel integrase inhibitor resistance mutation associated with low-level reduction in elvitegravir susceptibility.
Key Molecule: HIV1 Integrase (HIV1 IT)				[4]
Molecule Alteration	Missense mutation		p.I72V+p.I113V+p.Q148N+p.V151I+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	PCR; DNA sequencing assay
Experiment for Drug Resistance	PhenoSense assay
Mechanism Description	Q148N, a novel integrase inhibitor resistance mutation associated with low-level reduction in elvitegravir susceptibility.
Key Molecule: HIV1 Integrase (HIV1 IT)				[5]
Molecule Alteration	Missense mutation		p.I72V+p.I113V+p.V151I+p.L234V+p.R263K	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	TZM-bl cells	Uterus	Homo sapiens (Human)	CVCL_B478
Experiment for Molecule Alteration	Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay
Mechanism Description	Our results show that the R263k substitution decreased HIV-1 subtype C susceptibility to DTG and EVG by 3.3 and 50-fold, respectively. In subtype B, R263k conferred a somewhat lesser degree of drug resistance, that is, 2.1 and 25-fold decreases in susceptibility to DTG and EVG, respectively. R263k did not confer resistance against RAL in HIV-1 subtype C in accordance with results for subtype B.
Key Molecule: HIV1 Integrase (HIV1 IT)				[5]
Molecule Alteration	Missense mutation		p.K14R+p.D25E+p.V31I+p.L45S+p.I72V+p.E96D+p.F100Y+p.L101I+p.T112V+p.T124A+p.T125A+p.K136Q+p.V201I+p.K219N+p.N222K+p.L234I+p.R263K+p.A265V+p.R269K+p.D278A	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	TZM-bl cells	Uterus	Homo sapiens (Human)	CVCL_B478
Experiment for Molecule Alteration	Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay
Mechanism Description	Our results show that the R263k substitution decreased HIV-1 subtype C susceptibility to DTG and EVG by 3.3 and 50-fold, respectively. In subtype B, R263k conferred a somewhat lesser degree of drug resistance, that is, 2.1 and 25-fold decreases in susceptibility to DTG and EVG, respectively. R263k did not confer resistance against RAL in HIV-1 subtype C in accordance with results for subtype B.
Key Molecule: HIV1 Integrase (HIV1 IT)				[3]
Molecule Alteration	Missense mutation		p.I72V+p.I113V+p.G118R+p.E138K+p.V151I+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
In Vitro Model	BL21 cells	Cerebrospinal fluid	Homo sapiens (Human)	CVCL_M639
Experiment for Molecule Alteration	Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay
Mechanism Description	Amino acid changes in IN may contribute to elvitegravir resistance or sensitivity.
Key Molecule: HIV1 Integrase (HIV1 IT)				[3]
Molecule Alteration	Missense mutation		p.I72V+p.I113V+p.G118R+p.V151I+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
In Vitro Model	BL21 cells	Cerebrospinal fluid	Homo sapiens (Human)	CVCL_M639
Experiment for Molecule Alteration	Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay
Mechanism Description	Amino acid changes in IN may contribute to elvitegravir resistance or sensitivity.
Key Molecule: HIV1 Integrase (HIV1 IT)				[3]
Molecule Alteration	Missense mutation		p.H51Y+p.I72V+p.I113V+p.V151I+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
In Vitro Model	BL21 cells	Cerebrospinal fluid	Homo sapiens (Human)	CVCL_M639
Experiment for Molecule Alteration	Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay
Mechanism Description	Amino acid changes in IN may contribute to elvitegravir resistance or sensitivity.
Key Molecule: HIV1 Integrase (HIV1 IT)				[3]
Molecule Alteration	Missense mutation		p.E11D+p.K14R+p.S24N+p.V31I+p.M50I+p.L74I+p.A91E+p.L101I+p.T112V+p.G118R+p.S119R+p.T124A+p.T125A+p.A133T+p.G134N+p.I135V+p.K136T+p.E138K+p.V165I+p.V201I+p.T206S+p.T218I+p.L234I+p.S283D	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
In Vitro Model	BL21 cells	Cerebrospinal fluid	Homo sapiens (Human)	CVCL_M639
Experiment for Molecule Alteration	Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay
Mechanism Description	Amino acid changes in IN may contribute to elvitegravir resistance or sensitivity.
Key Molecule: HIV1 Integrase (HIV1 IT)				[3]
Molecule Alteration	Missense mutation		p.E11D+p.K14R+p.S24N+p.V31I+p.M50I+p.L74I+p.A91E+p.L101I+p.T112V+p.G118R+p.S119R+p.T124A+p.T125A+p.A133T+p.G134N+p.I135V+p.K136T+p.V165I+p.V201I+p.T206S+p.T218I+p.L234I+p.S283D	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
In Vitro Model	BL21 cells	Cerebrospinal fluid	Homo sapiens (Human)	CVCL_M639
Experiment for Molecule Alteration	Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay
Mechanism Description	Amino acid changes in IN may contribute to elvitegravir resistance or sensitivity.
Key Molecule: HIV1 Integrase (HIV1 IT)				[3]
Molecule Alteration	Missense mutation		p.E11D+p.K14R+p.S24N+p.V31I+p.M50I+p.H51Y+p.L74I+p.A91E+p.L101I+p.T112V+p.S119R+p.T124A+p.T125A+p.A133T+p.G134N+p.I135V+p.K136T+p.V165I+p.V201I+p.T206S+p.T218I+p.L234I+p.S283D	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
In Vitro Model	BL21 cells	Cerebrospinal fluid	Homo sapiens (Human)	CVCL_M639
Experiment for Molecule Alteration	Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay
Mechanism Description	Amino acid changes in IN may contribute to elvitegravir resistance or sensitivity.
Key Molecule: HIV1 Integrase (HIV1 IT)				[2]
Molecule Alteration	Missense mutation		p.R20K+p.V31I+p.L45I+p.L101I+p.I135IV+p.N155H+p.E157Q+p.K160Q+p.V201I+p.K215N+p.A265V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	RT-PCR; Sequencing assay
Experiment for Drug Resistance	PhenoSense assay
Mechanism Description	Five mutations (A49P, L68FL, T97A, E138k and L234V) were implicated in emergent dolutegravir resistance, with a concomitant severe compromise in viral replicative capacity.
Key Molecule: HIV1 Integrase (HIV1 IT)				[2]
Molecule Alteration	Missense mutation		p.R20K+p.V31I+p.L45I+p.L101I+p.K111KR+p.I135IV+p.E157Q+p.K160Q+p.V201I+p.K215N+p.A265AV	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	RT-PCR; Sequencing assay
Experiment for Drug Resistance	PhenoSense assay
Mechanism Description	Five mutations (A49P, L68FL, T97A, E138k and L234V) were implicated in emergent dolutegravir resistance, with a concomitant severe compromise in viral replicative capacity.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.S123G+p.T124A+p.K127R+p.G140S+p.Q148K+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E366Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.S123G+p.T124A+p.K127R+p.G140S+p.Q148H+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E365Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.S123G+p.T124A+p.K127R+p.G140S+p.Q148R+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E364Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.S123G+p.T124A+p.K127R+p.N155H+p.E157Q+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E356Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.S119P+p.S123G+p.T124A+p.K127R+p.N155H+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E352Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.M50I+p.I72V+p.S123G+p.T124A+p.K127R+p.N155H+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E350Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.S123G+p.T124A+p.K127R+p.Q148R+p.E157Q+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E363Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.S119P+p.S123G+p.T124A+p.K127R+p.Q148R+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E362Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.M50I+p.I72V+p.S123G+p.T124A+p.K127R+p.Q148R+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E361Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.S123G+p.T124A+p.K127R+p.S147G+p.E157Q+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E339Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.S119P+p.S123G+p.T124A+p.K127R+p.S147G+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E337Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.M50I+p.I72V+p.S123G+p.T124A+p.K127R+p.S147G+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E334Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.E92Q+p.S123G+p.T124A+p.K127R+p.E157Q+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E351Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.E92Q+p.S119P+p.S123G+p.T124A+p.K127R+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E357Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.M50I+p.I72V+p.E92Q+p.S123G+p.T124A+p.K127R+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E353Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.T66I+p.I72V+p.S123G+p.T124A+p.K127R+p.E157Q+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E349Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.T66I+p.I72V+p.S119P+p.S123G+p.T124A+p.K127R+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E346Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.M50I+p.T66I+p.I72V+p.S123G+p.T124A+p.K127R+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E345Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.S123G+p.T124A+p.K127R+p.S153Y+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E323Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.S123G+p.T124A+p.K127R+p.S153F+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E321Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.S123G+p.T124A+p.K127R+p.V151L+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E344Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.S123G+p.T124A+p.K127R+p.V151A+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E320Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.S123G+p.T124A+p.K127R+p.Q146R+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E328Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.S123G+p.T124A+p.K127R+p.Q146P+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E333Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.S123G+p.T124A+p.K127R+p.Q146L+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E341Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.S123G+p.T124A+p.K127R+p.Q146I+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E360Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.S123G+p.T124A+p.K127R+p.P145S+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E347Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.S123G+p.T124A+p.K127R+p.G140S+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E329Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.S123G+p.T124A+p.K127R+p.G140C+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E335Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.S123G+p.T124A+p.K127R+p.G140A+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E330Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.I72N+p.S123G+p.T124A+p.K127R+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E332Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.I72A+p.S123G+p.T124A+p.K127R+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E326Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.H51Y+p.I72V+p.S123G+p.T124A+p.K127R+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E322Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.S123G+p.T124A+p.K127R+p.D232N+p.R263K	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E327Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.S123G+p.T124A+p.K127R+p.N155H+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E354Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.S123G+p.T124A+p.K127R+p.Q148R+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E359Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.S123G+p.T124A+p.K127R+p.Q148K+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E358Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.S123G+p.T124A+p.K127R+p.Q148H+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E336Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.S123G+p.T124A+p.K127R+p.S147G+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E331Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.S123G+p.T124A+p.K127R+p.Y143R+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E324Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.E92Q+p.S123G+p.T124A+p.K127R+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E348Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.E92G+p.S123G+p.T124A+p.K127R+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E343Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.T66K+p.I72V+p.S123G+p.T124A+p.K127R+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E355Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.T66I+p.I72V+p.S123G+p.T124A+p.K127R+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E340Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.T66A+p.I72V+p.S123G+p.T124A+p.K127R+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E338Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.F121Y	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E342Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.T97A	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E325Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[6]
Molecule Alteration	Missense mutation		p.D6E+p.P30S+p.S39C+p.K111KR+p.V201I+p.T206S+p.S230H+p.D253DE+p.S283SG	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included D6E, P30S, S39C, K111KR, V201I, T206S, S230H, D253DE, S283SG.
Key Molecule: HIV1 Integrase (HIV1 IT)				[6]
Molecule Alteration	Missense mutation		p.D6E+p.S17N+p.A98G+p.L101I+p.T124N+p.K136N+p.F181L+p.V201I+p.A265V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included D6E, S17N, A98G, L101I, T124N, K136N, F181L, V201I, A265V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[6]
Molecule Alteration	Missense mutation		p.K7KR+p.E11D+p.K14R+p.A21T+p.A23V+p.D25DE+p.I72IV+p.L101I+p.K103KR+p.S119T	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included K7KR, E11D, K14R, A21T, A23V, D25DE, I72IV, L101I, K103KR, S119T.
Key Molecule: HIV1 Integrase (HIV1 IT)				[6]
Molecule Alteration	Missense mutation		p.E11D+p.F26Y+p.L28I+p.V37I+p.S39C+p.M50I+p.G106A+p.T112R+p.T125A+p.V126L+p.V201I+p.T206S+p.K211R+p.K219N+p.N222K+p.S255N+p.I268L+p.M275V+p.V281M+p.S283G	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, F26Y, L28I, V37I, S39C, M50I, G106A, T112R, T125A, V126L, V201I, T206S, K211R, K219N, N222K, S255N, I268L, M275V, V281M, S283G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[6]
Molecule Alteration	Missense mutation		p.M50I+p.K156N+p.V201I	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included M50I, K156N, V201I.
Key Molecule: HIV1 Integrase (HIV1 IT)				[6]
Molecule Alteration	Missense mutation		p.S17N+p.M50I+p.L101I+p.T124A+p.G163E+p.G193E+p.V201I+p.D279N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17N, M50I, L101I, T124A, G163E, G193E, V201I, D279N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[6]
Molecule Alteration	Missense mutation		p.S17C+p.T112R+p.T125A+p.K188R+p.T218I+p.A265V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17C, T112R, T125A, K188R, T218I, A265V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[6]
Molecule Alteration	Missense mutation		p.K14R+p.K34R+p.V201I+p.T206S+p.N254Q+p.S255G+p.I267IV+p.M275MV	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included K14R, K34R, V201I, T206S, N254Q, S255G, I267IV, M275MV.
Key Molecule: HIV1 Integrase (HIV1 IT)				[7]
Molecule Alteration	Missense mutation		p.E10D+p.K14KR+p.L101I+p.S119G+p.T122I+p.T124A+p.V201I+p.I220L	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E10D, K14KR, L101I, S119G, T122I, T124A, V201I, I220L.
Key Molecule: HIV1 Integrase (HIV1 IT)				[7]
Molecule Alteration	Missense mutation		p.S17N+p.V31VI+p.V54I+p.L101I+p.T124A+p.T125A+p.I208L+p.K215N+p.L234I+p.N254K+p.S255SG+p.A265V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17N, V31VI, V54I, L101I, T124A, T125A, I208L, K215N, L234I, N254K, S255SG, A265V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[7]
Molecule Alteration	Missense mutation		p.S17N+p.S39C+p.L101I+p.T112V+p.T124A+p.V201I+p.T218S+p.I268L	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17N, S39C, L101I, T112V, T124A, V201I, T218S, I268L.
Key Molecule: HIV1 Integrase (HIV1 IT)				[7]
Molecule Alteration	Missense mutation		p.S24G+p.S39C+p.V79A+p.T97TA+p.L101I+p.T124N+p.V201I+p.Q216R+p.K219Q+p.A265V+p.S283G	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S24G, S39C, V79A, T97TA, L101I, T124N, V201I, Q216R, K219Q, A265V, S283G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.D6E+p.K7KR+p.S17N+p.L74I+p.L101I+p.T124A+p.T125TA+p.G163D+p.F181FL+p.R187K+p.K188KR+p.K211T+p.E212A+p.Q221S	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included D6E, K7KR, S17N, L74I, L101I, T124A, T125TA, G163D, F181FL, R187K, K188KR, K211T, E212A, Q221S.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.S17N+p.A23AS+p.V31I+p.G47GR+p.E48EG+p.I72IN+p.I84IM+p.L101I+p.K103KR+p.T124S+p.T125A+p.K156N+p.G189GR+p.E198D+p.V201I+p.T206S+p.D232E+p.A265V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17N, A23AS, V31I, G47GR, E48EG, I72IN, I84IM, L101I, K103KR, T124S, T125A, K156N, G189GR, E198D, V201I, T206S, D232E, A265V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.E11D+p.S24N+p.M50I+p.S119P+p.T124A+p.I208IV+p.L241LF+p.D253E+p.D256E	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, S24N, M50I, S119P, T124A, I208IV, L241LF, D253E, D256E.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.K34R+p.L101LI+p.T112V+p.T125TA+p.I135IV+p.E138ED+p.V201I+p.L234I	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included K34R, L101LI, T112V, T125TA, I135IV, E138ED, V201I, L234I.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.S17N+p.L28LI+p.S39C+p.L101LI+p.T124N+p.T125A+p.I135IV+p.F181FL+p.I191IM+p.G193GE+p.V201I+p.T206S+p.K219N+p.N222K+p.A265AV+p.I268IL+p.D270DH	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17N, L28LI, S39C, L101LI, T124N, T125A, I135IV, F181FL, I191IM, G193GE, V201I, T206S, K219N, N222K, A265AV, I268IL, D270DH.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.L101I+p.K156N+p.I208L	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included L101I, K156N, I208L.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.M50L+p.T112V+p.T124TA+p.V201I+p.I203IM+p.T206TS+p.T218S+p.Q221R	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included M50L, T112V, T124TA, V201I, I203IM, T206TS, T218S, Q221R.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.S17N+p.I72IV+p.K111T+p.T124A+p.D253DE+p.D256E	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17N, I72IV, K111T, T124A, D253DE, D256E.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.S17N+p.V54I+p.T112I+p.T124N+p.V201I+p.D256E	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17N, V54I, T112I, T124N, V201I, D256E.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.S17N+p.V31I+p.I72IV+p.L101I+p.T124A+p.E157Q+p.K160Q+p.D232E+p.A265V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17N, V31I, I72IV, L101I, T124A, E157Q, K160Q, D232E, A265V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.E11D+p.V31VI+p.L101I+p.K111T+p.T112IV+p.S119TP+p.T125A+p.V126A+p.V150A+p.V201I	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, V31VI, L101I, K111T, T112IV, S119TP, T125A, V126A, V150A, V201I.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.M50I+p.L101I+p.G193E+p.V201I+p.S230N+p.D256E+p.D286N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included M50I, L101I, G193E, V201I, S230N, D256E, D286N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.S17N+p.A91T+p.L101I+p.T124A+p.K156N+p.V165VI+p.V201I+p.T218TS+p.Y227F+p.D229E+p.D253Y+p.D256E+p.A265V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17N, A91T, L101I, T124A, K156N, V165VI, V201I, T218TS, Y227F, D229E, D253Y, D256E, A265V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.K7KR+p.S17N+p.R20K+p.A23AV+p.S119G+p.T122V+p.T124A+p.T125A+p.V201I+p.T206S+p.D288N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included K7KR, S17N, R20K, A23AV, S119G, T122V, T124A, T125A, V201I, T206S, D288N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.K7R+p.S17N+p.T124NS+p.I220M+p.Y227F+p.A265V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included K7R, S17N, T124NS, I220M, Y227F, A265V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.S39C+p.G59E+p.T124N+p.T125A+p.V126L+p.M154L+p.V201I	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S39C, G59E, T124N, T125A, V126L, M154L, V201I.
Key Molecule: HIV1 Integrase (HIV1 IT)				[6]
Molecule Alteration	Missense mutation		p.K14R+p.R20K+p.S24N+p.D25E+p.V31I+p.G59E+p.I60V+p.L101I+p.T124A+p.T125TA+p.V165VI+p.K215KR+p.N222K	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included K14R, R20K, S24N, D25E, V31I, G59E, I60V, L101I, T124A, T125TA, V165VI, K215KR, N222K.
Key Molecule: HIV1 Integrase (HIV1 IT)				[6]
Molecule Alteration	Missense mutation		p.E13ED+p.S17C+p.T124N+p.T125A+p.I182V+p.K219N+p.N222K+p.D288N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E13ED, S17C, T124N, T125A, I182V, K219N, N222K, D288N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[6]
Molecule Alteration	Missense mutation		p.K7R+p.S17N+p.L28I+p.V151I+p.Y227F+p.D253Y+p.D256E+p.R284G	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included K7R, S17N, L28I, V151I, Y227F, D253Y, D256E, R284G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[6]
Molecule Alteration	Missense mutation		p.K7R+p.E11D+p.D25E+p.V31I+p.M50MT+p.I72IV+p.L101I+p.K111AT+p.S119SG+p.T122TI+p.T124TN+p.E138ED+p.K188KR+p.V201I+p.Q216H+p.A265AV	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included K7R, E11D, D25E, V31I, M50MT, I72IV, L101I, K111AT, S119SG, T122TI, T124TN, E138ED, K188KR, V201I, Q216H, A265AV.
Key Molecule: HIV1 Integrase (HIV1 IT)				[6]
Molecule Alteration	Missense mutation		p.E11D+p.K14R+p.S17T+p.S39SC+p.I60V+p.T112TI+p.I113IVL+p.T124A+p.T206S+p.E212A+p.N254NS+p.S283SG+p.R284RG	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, K14R, S17T, S39SC, I60V, T112TI, I113IVL, T124A, T206S, E212A, N254NS, S283SG, R284RG.
Key Molecule: HIV1 Integrase (HIV1 IT)				[6]
Molecule Alteration	Missense mutation		p.D6E+p.D25E+p.L101I+p.V110T+p.T112V+p.K156N+p.E157Q+p.K215N+p.D232E+p.L234H+p.D253E+p.D256E+p.D270N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included D6E, D25E, L101I, V110T, T112V, K156N, E157Q, K215N, D232E, L234H, D253E, D256E, D270N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[6]
Molecule Alteration	Missense mutation		p.K14R+p.V31I+p.S39C+p.L45Q+p.I84IM+p.K111T+p.V201I+p.K211KR+p.S230N+p.L234I+p.I251IT+p.D253DAE+p.N254ND+p.D256E	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included K14R, V31I, S39C, L45Q, I84IM, K111T, V201I, K211KR, S230N, L234I, I251IT, D253DAE, N254ND, D256E.
Key Molecule: HIV1 Integrase (HIV1 IT)				[7]
Molecule Alteration	Missense mutation		p.L101I+p.T124TA+p.T125A+p.I135V+p.F181L+p.K188R+p.G193R+p.V201I+p.T206S+p.T218I+p.A265V+p.V281M	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included L101I, T124TA, T125A, I135V, F181L, K188R, G193R, V201I, T206S, T218I, A265V, V281M.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.K7KQ+p.L101IV+p.T124X+p.T125A+p.V126IML+p.K156KN+p.L234I	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included K7KQ, L101IV, T124X, T125A, V126IML, K156KN, L234I.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.S17N+p.G59A+p.L101I+p.T124S+p.T125A+p.K136N+p.K160KR+p.V201I+p.I203M+p.S255R	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17N, G59A, L101I, T124S, T125A, K136N, K160KR, V201I, I203M, S255R.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.V31I+p.I84IM+p.L101I+p.K111T+p.I135V+p.V201I+p.T206S+p.K211R+p.E212T+p.K219N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included V31I, I84IM, L101I, K111T, I135V, V201I, T206S, K211R, E212T, K219N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.S17N+p.V31VI+p.M50MI+p.L101I+p.T112V+p.T124N+p.I135V+p.G193D+p.S195C+p.D207DG+p.D256E+p.A265V+p.D278A	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17N, V31VI, M50MI, L101I, T112V, T124N, I135V, G193D, S195C, D207DG, D256E, A265V, D278A.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.K14R+p.S17N+p.A23AV+p.V31I+p.C56Y+p.L101I+p.T112TI+p.T124S+p.T125A+p.I135V+p.K160Q+p.T218S+p.I251L	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included K14R, S17N, A23AV, V31I, C56Y, L101I, T112TI, T124S, T125A, I135V, K160Q, T218S, I251L.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.V31I+p.L101I+p.I203IM+p.T206S+p.K211R+p.Q216H+p.I268L+p.D270H+p.R284G	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included V31I, L101I, I203IM, T206S, K211R, Q216H, I268L, D270H, R284G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.S17N+p.E96D+p.L101I+p.T124A+p.V165I+p.F181FL+p.G193GDE+p.Y194YC+p.V201I+p.S255K+p.A265AV+p.I268IL+p.R269RK+p.D270DH	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17N, E96D, L101I, T124A, V165I, F181FL, G193GDE, Y194YC, V201I, S255K, A265AV, I268IL, R269RK, D270DH.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.I84IM+p.L101I+p.S119T+p.K156KN+p.G193S+p.T206S+p.N254Q+p.S255SG+p.A265AV+p.S283G	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I84IM, L101I, S119T, K156KN, G193S, T206S, N254Q, S255SG, A265AV, S283G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.E10D+p.T124A+p.T125A+p.I135IV+p.K156N+p.V201I+p.I220V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E10D, T124A, T125A, I135IV, K156N, V201I, I220V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.S17C+p.I72IV+p.K111KN+p.K173KR	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17C, I72IV, K111KN, K173KR.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.S17N+p.M50MI+p.L63M+p.I113IV+p.T124A+p.T125A+p.K215N+p.I220L+p.D279G	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17N, M50MI, L63M, I113IV, T124A, T125A, K215N, I220L, D279G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.E11D+p.V31VI+p.L101IV+p.K111T+p.S119SG+p.T122I+p.F181FI+p.V201I+p.T206PS	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, V31VI, L101IV, K111T, S119SG, T122I, F181FI, V201I, T206PS.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.S17N+p.S24SG+p.F100FC+p.L101I+p.T112I+p.T124A+p.T125A+p.G134N+p.K136T+p.V201I+p.T206S+p.Y227F+p.L234I+p.S255N+p.D256E+p.S283G	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17N, S24SG, F100FC, L101I, T112I, T124A, T125A, G134N, K136T, V201I, T206S, Y227F, L234I, S255N, D256E, S283G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.D6E+p.E10D+p.L45V+p.L101I+p.S119P+p.T122I+p.T124A	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included D6E, E10D, L45V, L101I, S119P, T122I, T124A.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.S17N+p.R20RK+p.V31I+p.M50I+p.T124A+p.K156N+p.V165I+p.F181FL+p.V201I+p.S255K+p.I268L+p.D270DN	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17N, R20RK, V31I, M50I, T124A, K156N, V165I, F181FL, V201I, S255K, I268L, D270DN.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.V31VMI+p.M50I+p.I72X+p.L101I+p.K103KR+p.H114HY+p.I135IV+p.V176L+p.A205S+p.T206S+p.T218S+p.Y227F+p.S255N+p.D256E+p.S283SG	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included V31VMI, M50I, I72X, L101I, K103KR, H114HY, I135IV, V176L, A205S, T206S, T218S, Y227F, S255N, D256E, S283SG.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.K111T+p.Q216H+p.D232DE+p.D256DE	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included K111T, Q216H, D232DE, D256DE.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.E11D+p.V31VI+p.L101I+p.K111T+p.T112IV+p.S119TP+p.T125A+p.V126A+p.Q148QR+p.V150A+p.V201I+p.Q209QP	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, V31VI, L101I, K111T, T112IV, S119TP, T125A, V126A, Q148QR, V150A, V201I, Q209QP.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.V31VA+p.T124TA+p.T125TA+p.V201I+p.S230N+p.L234I+p.A265V+p.D270N+p.R284RG	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included V31VA, T124TA, T125TA, V201I, S230N, L234I, A265V, D270N, R284RG.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.E10ED+p.E11ED+p.E13ED+p.M50L+p.L101I+p.K111T+p.T125A+p.A128T+p.Y227F+p.S230N+p.D256E+p.A265V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E10ED, E11ED, E13ED, M50L, L101I, K111T, T125A, A128T, Y227F, S230N, D256E, A265V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.R20K+p.L101I+p.K160KR+p.G193E+p.V201VI+p.E212EA+p.D256E	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included R20K, L101I, K160KR, G193E, V201VI, E212EA, D256E.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.P90PS+p.L101I+p.M154L+p.V201VI	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included P90PS, L101I, M154L, V201VI.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.C56CS+p.I72IV+p.K111KT+p.I113IVM+p.I208IL+p.K211KR+p.N254K+p.A265V+p.S283G	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included C56CS, I72IV, K111KT, I113IVM, I208IL, K211KR, N254K, A265V, S283G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.K14R+p.V31I+p.L45LV+p.T124X+p.T125TA+p.L172LP+p.K215N+p.S230N+p.R231K+p.D253E+p.N254Q+p.S255G+p.D256E	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included K14R, V31I, L45LV, T124X, T125TA, L172LP, K215N, S230N, R231K, D253E, N254Q, S255G, D256E.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.S17N+p.A23AV+p.L101I+p.K211Q+p.T218TS+p.D256E	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17N, A23AV, L101I, K211Q, T218TS, D256E.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.K7R+p.L28I+p.S39C+p.D64DN+p.P90PS+p.A91AS+p.T124A+p.I141IV+p.V201VI+p.I203IM+p.T206TS+p.I208L+p.Q216H+p.L234LI	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included K7R, L28I, S39C, D64DN, P90PS, A91AS, T124A, I141IV, V201VI, I203IM, T206TS, I208L, Q216H, L234LI.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.E11D+p.E13D+p.A21T+p.L101I+p.S119G+p.T122I+p.T124S+p.K136N+p.D256E	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, E13D, A21T, L101I, S119G, T122I, T124S, K136N, D256E.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.E10D+p.E11ED+p.V31VI+p.S39SC+p.M50I+p.I60IM+p.G106A+p.K156N+p.V201I+p.T206S+p.D232E+p.L234H	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E10D, E11ED, V31VI, S39SC, M50I, I60IM, G106A, K156N, V201I, T206S, D232E, L234H.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.V31I+p.I72IV+p.G106A+p.T125TA+p.S230N+p.D232E	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included V31I, I72IV, G106A, T125TA, S230N, D232E.
Key Molecule: HIV1 Integrase (HIV1 IT)				[6]
Molecule Alteration	Missense mutation		p.S17N+p.L101I+p.T112I+p.T124N+p.G163E+p.V201I+p.A205S+p.T206S+p.D256E	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17N, L101I, T112I, T124N, G163E, V201I, A205S, T206S, D256E.
Key Molecule: HIV1 Integrase (HIV1 IT)				[6]
Molecule Alteration	Missense mutation		p.V31I+p.D55DN+p.I72IV+p.L101I+p.K103R+p.T112I+p.T124A+p.T125A+p.V126VI+p.V201I+p.A205T+p.K211R+p.I220L+p.Y227F+p.D253Y+p.A265V+p.R284G	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included V31I, D55DN, I72IV, L101I, K103R, T112I, T124A, T125A, V126VI, V201I, A205T, K211R, I220L, Y227F, D253Y, A265V, R284G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[6]
Molecule Alteration	Missense mutation		p.E11D+p.S17T+p.A23V+p.I72IV+p.T124A+p.G193E+p.V201I+p.I208M+p.E212SY+p.Q216H+p.I220L	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, S17T, A23V, I72IV, T124A, G193E, V201I, I208M, E212SY, Q216H, I220L.
Key Molecule: HIV1 Integrase (HIV1 IT)				[7]
Molecule Alteration	Missense mutation		p.E10A+p.E11D+p.S17N+p.V32I+p.K42R+p.I84L+p.L101I+p.S119P+p.T124A+p.T125A+p.I135V+p.K136Q+p.V165I+p.V201I+p.T218I+p.D256E+p.S283G	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E10A, E11D, S17N, V32I, K42R, I84L, L101I, S119P, T124A, T125A, I135V, K136Q, V165I, V201I, T218I, D256E, S283G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[7]
Molecule Alteration	Missense mutation		p.S39C+p.D41DN+p.M50I+p.L101I+p.T124A+p.T125A+p.V201VI+p.D253E+p.S283G+p.R284G	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S39C, D41DN, M50I, L101I, T124A, T125A, V201VI, D253E, S283G, R284G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[7]
Molecule Alteration	Missense mutation		p.K14R+p.V31VA+p.C56S+p.L101I+p.V201I+p.I208IL+p.I220L+p.Y227F+p.D256E+p.V281VA	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included K14R, V31VA, C56S, L101I, V201I, I208IL, I220L, Y227F, D256E, V281VA.
Key Molecule: HIV1 Integrase (HIV1 IT)				[7]
Molecule Alteration	Missense mutation		p.A23AV+p.L101LF+p.K156N+p.R187RK+p.K188R+p.V201I+p.S230SN+p.D256E	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included A23AV, L101LF, K156N, R187RK, K188R, V201I, S230SN, D256E.
Key Molecule: HIV1 Integrase (HIV1 IT)				[7]
Molecule Alteration	Missense mutation		p.K14KR+p.V31I+p.D41G+p.K42Q+p.L45Q+p.I84IM+p.F100Y+p.L101I+p.T112V+p.T124A+p.T125A+p.K136Q+p.V201I+p.L234I+p.D278A+p.S283G+p.R284G	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included K14KR, V31I, D41G, K42Q, L45Q, I84IM, F100Y, L101I, T112V, T124A, T125A, K136Q, V201I, L234I, D278A, S283G, R284G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.K7R+p.L28I+p.S39C+p.M50I+p.L101I+p.F181L+p.V201I+p.A205S+p.K215N+p.Q221R+p.N222K	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included K7R, L28I, S39C, M50I, L101I, F181L, V201I, A205S, K215N, Q221R, N222K.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.E10D+p.V31I+p.M50MI+p.I84IML+p.L101I+p.G106A+p.K111X+p.T112X+p.T124TA+p.T125TA+p.I135IV+p.V151I	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E10D, V31I, M50MI, I84IML, L101I, G106A, K111X, T112X, T124TA, T125TA, I135IV, V151I.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.E11D+p.K14KR+p.S24SN+p.L28I+p.M50MIT+p.V201VI+p.I203IM+p.T218I	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, K14KR, S24SN, L28I, M50MIT, V201VI, I203IM, T218I.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.S17N+p.L28I+p.V32VI+p.S39C+p.M50MI+p.E138EK+p.V201I+p.K211Q	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17N, L28I, V32VI, S39C, M50MI, E138EK, V201I, K211Q.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.S17N+p.K34KR+p.M50L+p.I84IM+p.T124A+p.T125A+p.V201VI+p.A205S+p.T206S+p.I208IL+p.K211KR+p.E212EA	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17N, K34KR, M50L, I84IM, T124A, T125A, V201VI, A205S, T206S, I208IL, K211KR, E212EA.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.V31I+p.M50I+p.C65CG+p.I72IV+p.N117NK+p.T124N+p.T125A+p.E138D+p.D167E+p.V201I+p.A265V+p.D286N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included V31I, M50I, C65CG, I72IV, N117NK, T124N, T125A, E138D, D167E, V201I, A265V, D286N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.V54I+p.L101I+p.T124N+p.T125M+p.G163T+p.L234LF+p.L241LF+p.L242LF+p.D253E+p.N254SG	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included V54I, L101I, T124N, T125M, G163T, L234LF, L241LF, L242LF, D253E, N254SG.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.S81SR+p.A91T+p.L101I+p.S119P+p.T122I+p.T124TA+p.N144NH+p.I208M+p.S255G+p.S283G+p.R284G	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S81SR, A91T, L101I, S119P, T122I, T124TA, N144NH, I208M, S255G, S283G, R284G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.S17N+p.E96D+p.L101I+p.T124A+p.G140GS+p.Q148QH+p.V165I+p.F181FL+p.G193D+p.Y194YC+p.V201I+p.S255K+p.I268L+p.D270H	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17N, E96D, L101I, T124A, G140GS, Q148QH, V165I, F181FL, G193D, Y194YC, V201I, S255K, I268L, D270H.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.S17SN+p.V31I+p.T115TA+p.T124N+p.T125A+p.A205AS+p.T206TS+p.D207DE+p.D232E+p.L234I+p.D253E+p.D256E	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17SN, V31I, T115TA, T124N, T125A, A205AS, T206TS, D207DE, D232E, L234I, D253E, D256E.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.K14R+p.R20RK+p.A91E+p.L101I+p.S119R+p.T124N+p.G193D+p.V201I+p.T206S+p.I208IL+p.D256DE+p.I268L+p.R269RK+p.D270DH	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included K14R, R20RK, A91E, L101I, S119R, T124N, G193D, V201I, T206S, I208IL, D256DE, I268L, R269RK, D270DH.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.K14R+p.V31I+p.L101I+p.T112I+p.T124A+p.T125A+p.G134N+p.I135V+p.K136T+p.I162IV+p.V201I+p.I203M+p.T206S+p.Y227F+p.L234I+p.S255N+p.D256E+p.S283G	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included K14R, V31I, L101I, T112I, T124A, T125A, G134N, I135V, K136T, I162IV, V201I, I203M, T206S, Y227F, L234I, S255N, D256E, S283G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.D6DE+p.S17N+p.L45V+p.K111KR+p.T112I+p.T124N+p.T125A+p.I203IM+p.T206S+p.D256E	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included D6DE, S17N, L45V, K111KR, T112I, T124N, T125A, I203IM, T206S, D256E.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.A23V+p.S39C+p.L101I+p.T124N+p.T125A+p.I135V+p.D167E+p.F181L+p.V201I+p.K215N+p.D270N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included A23V, S39C, L101I, T124N, T125A, I135V, D167E, F181L, V201I, K215N, D270N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.S57SG+p.G59E+p.L101I+p.T206S+p.D256E+p.S283SG	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S57SG, G59E, L101I, T206S, D256E, S283SG.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.S17N+p.V31I+p.I72IV+p.L101I+p.K111T+p.T124A+p.V165I+p.F181L+p.D256E	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17N, V31I, I72IV, L101I, K111T, T124A, V165I, F181L, D256E.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.S39SN+p.P90PS+p.L101I+p.M154I+p.V201I+p.T210TI+p.K215N+p.L234LF+p.L242LF+p.D279G	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S39SN, P90PS, L101I, M154I, V201I, T210TI, K215N, L234LF, L242LF, D279G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.S24G+p.D25E+p.L28I+p.L45V+p.V201I+p.S230N+p.R269RG+p.R284G	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S24G, D25E, L28I, L45V, V201I, S230N, R269RG, R284G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.S17N+p.A23AT+p.N27G+p.L28I+p.L45Q+p.D256DE	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17N, A23AT, N27G, L28I, L45Q, D256DE.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.S17N+p.S39C+p.D41DG+p.V79VI+p.L101I+p.T112TI+p.T124N+p.I203M+p.T206S+p.Q209QR+p.D253DE+p.D256E+p.D279DN	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17N, S39C, D41DG, V79VI, L101I, T112TI, T124N, I203M, T206S, Q209QR, D253DE, D256E, D279DN.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.S17SN+p.L101LI+p.V151VI+p.M154I+p.I203IV	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17SN, L101LI, V151VI, M154I, I203IV.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.D6E+p.S17N+p.V31I+p.T112IV+p.T124N+p.T125V+p.L158F+p.H171HQ+p.D232E+p.A265V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included D6E, S17N, V31I, T112IV, T124N, T125V, L158F, H171HQ, D232E, A265V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.S17N+p.L28I+p.P30A+p.G59E+p.I60V+p.L101I+p.T124A+p.V201I+p.T206S+p.D270DN	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17N, L28I, P30A, G59E, I60V, L101I, T124A, V201I, T206S, D270DN.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.E11D+p.L101I+p.F181L+p.G193E+p.V201I+p.I220L+p.Y227F+p.D256E+p.D279N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, L101I, F181L, G193E, V201I, I220L, Y227F, D256E, D279N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.M22MI+p.L45V+p.E92EG+p.L101I+p.G163E+p.S195C+p.Q216H+p.K219Q+p.D278A	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included M22MI, L45V, E92EG, L101I, G163E, S195C, Q216H, K219Q, D278A.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.P30A+p.A49AS+p.P90PS+p.L101I+p.T112A+p.S123C+p.T124N+p.V201I+p.T218I+p.D256E+p.S283G	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included P30A, A49AS, P90PS, L101I, T112A, S123C, T124N, V201I, T218I, D256E, S283G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.R20K+p.K156KR+p.I200IM+p.V201I+p.D270DN	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included R20K, K156KR, I200IM, V201I, D270DN.
Key Molecule: HIV1 Integrase (HIV1 IT)				[6]
Molecule Alteration	Missense mutation		p.K156N+p.I161L+p.V201I+p.T218S+p.Q221E+p.N222K	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included K156N, I161L, V201I, T218S, Q221E, N222K.
Key Molecule: HIV1 Integrase (HIV1 IT)				[6]
Molecule Alteration	Missense mutation		p.V31I+p.M50I+p.L63I+p.L74V+p.E96D+p.L101I+p.T124N+p.T125A+p.G193E+p.V201I+p.I208IL+p.K211KR+p.E212X+p.T218S+p.S230N+p.D232E+p.D256E	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included V31I, M50I, L63I, L74V, E96D, L101I, T124N, T125A, G193E, V201I, I208IL, K211KR, E212X, T218S, S230N, D232E, D256E.
Key Molecule: HIV1 Integrase (HIV1 IT)				[6]
Molecule Alteration	Missense mutation		p.R20K+p.L101I+p.K111T+p.T122I+p.T124A+p.V201I+p.R284RG+p.D286N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included R20K, L101I, K111T, T122I, T124A, V201I, R284RG, D286N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[6]
Molecule Alteration	Missense mutation		p.E11D+p.A21S+p.A23V+p.S24G+p.V37I+p.S39C+p.I60V+p.L101I+p.K219N+p.N222K	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, A21S, A23V, S24G, V37I, S39C, I60V, L101I, K219N, N222K.
Key Molecule: HIV1 Integrase (HIV1 IT)				[6]
Molecule Alteration	Missense mutation		p.E11D+p.S39C+p.L45Q+p.V201I+p.T218S	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, S39C, L45Q, V201I, T218S.
Key Molecule: HIV1 Integrase (HIV1 IT)				[6]
Molecule Alteration	Missense mutation		p.M50MI+p.T125A+p.I135V+p.M154MI+p.I162IV+p.V201I+p.K215N+p.L234I	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included M50MI, T125A, I135V, M154MI, I162IV, V201I, K215N, L234I.
Key Molecule: HIV1 Integrase (HIV1 IT)				[7]
Molecule Alteration	Missense mutation		p.K7KE+p.T66TP+p.I84IM+p.S119T+p.M154L+p.K160KI+p.V201I+p.T218S	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included K7KE, T66TP, I84IM, S119T, M154L, K160KI, V201I, T218S.
Key Molecule: HIV1 Integrase (HIV1 IT)				[7]
Molecule Alteration	Missense mutation		p.R20K+p.L45I+p.K156N+p.S230SN+p.L234LH	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included R20K, L45I, K156N, S230SN, L234LH.
Key Molecule: HIV1 Integrase (HIV1 IT)				[7]
Molecule Alteration	Missense mutation		p.D6E+p.E10D+p.E13ED+p.S17SN+p.V31VI+p.S57SN+p.G106A+p.T112TI+p.S119P+p.T122I+p.T124N+p.V201I+p.T206S+p.I208L+p.K211R+p.D256E	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included D6E, E10D, E13ED, S17SN, V31VI, S57SN, G106A, T112TI, S119P, T122I, T124N, V201I, T206S, I208L, K211R, D256E.
Key Molecule: HIV1 Integrase (HIV1 IT)				[7]
Molecule Alteration	Missense mutation		p.E11D+p.S24SN+p.D25E+p.L101LI+p.S119P+p.T122TI+p.K136N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, S24SN, D25E, L101LI, S119P, T122TI, K136N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[7]
Molecule Alteration	Missense mutation		p.S17N+p.V31VI+p.M50MI+p.L101I+p.T112TI+p.T124NS+p.T125V+p.G163E	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17N, V31VI, M50MI, L101I, T112TI, T124NS, T125V, G163E.
Key Molecule: HIV1 Integrase (HIV1 IT)				[7]
Molecule Alteration	Missense mutation		p.E11D+p.E13ED+p.G70GE+p.L101I+p.S119R+p.T122TI+p.T124TN+p.R187RK+p.K188KR+p.G193E+p.V201I+p.S283SG	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, E13ED, G70GE, L101I, S119R, T122TI, T124TN, R187RK, K188KR, G193E, V201I, S283SG.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.E11D+p.S24N+p.V31I+p.L101I+p.K136N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, S24N, V31I, L101I, K136N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.R20RK+p.I84IV+p.L101I+p.T112TI+p.T125TA+p.M154I+p.V165I+p.H171L+p.K211R	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included R20RK, I84IV, L101I, T112TI, T125TA, M154I, V165I, H171L, K211R.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.T124A+p.T125A+p.I135V+p.D167E+p.R284G	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included T124A, T125A, I135V, D167E, R284G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.E11D+p.S24N+p.K34KR+p.I72IV+p.I84M+p.A91T+p.L101I+p.T125V+p.V201I+p.K211KR+p.S230N+p.R262L+p.S283G	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, S24N, K34KR, I72IV, I84M, A91T, L101I, T125V, V201I, K211KR, S230N, R262L, S283G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.E10D+p.R20RK+p.M50I+p.L101I+p.T112I+p.S119P+p.T124A+p.T125A+p.I135L+p.T206S+p.D279DN	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E10D, R20RK, M50I, L101I, T112I, S119P, T124A, T125A, I135L, T206S, D279DN.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.S17N+p.D25DE+p.N27NS+p.G59GE+p.I72IV+p.V77VI+p.V79VI+p.I84IM+p.V88VI+p.L101I+p.S119T+p.T124S+p.T125A+p.T206S	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17N, D25DE, N27NS, G59GE, I72IV, V77VI, V79VI, I84IM, V88VI, L101I, S119T, T124S, T125A, T206S.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.D6E+p.E10D+p.S17N+p.A23V+p.E35Q+p.S39N+p.L45V+p.M50I+p.T124TN+p.V151VI+p.V201I+p.K264KR+p.E287EK	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included D6E, E10D, S17N, A23V, E35Q, S39N, L45V, M50I, T124TN, V151VI, V201I, K264KR, E287EK.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.E11D+p.V32VI+p.V37I+p.S39SC+p.D41DN+p.I60V+p.S119G+p.T122TI+p.T124N+p.T125A+p.V201I+p.I203M	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, V32VI, V37I, S39SC, D41DN, I60V, S119G, T122TI, T124N, T125A, V201I, I203M.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.E10ED+p.E11ED+p.S24X+p.L101I+p.K111R+p.I135IV+p.V201I+p.T206S+p.K211R+p.E212I+p.T218Q+p.K219Q+p.L241LF+p.L242LF+p.S255KQ	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E10ED, E11ED, S24X, L101I, K111R, I135IV, V201I, T206S, K211R, E212I, T218Q, K219Q, L241LF, L242LF, S255KQ.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.E10D+p.E11D+p.D25DE+p.F26FY+p.S39C+p.L45Q+p.L101I+p.T124A+p.I135V+p.T174TI+p.Q216H+p.R231RG	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E10D, E11D, D25DE, F26FY, S39C, L45Q, L101I, T124A, I135V, T174TI, Q216H, R231RG.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.D6DE+p.K14R+p.S24N+p.L74I+p.T112IV+p.T124N+p.T125A+p.G134N+p.K136T+p.V201I+p.T206S+p.L234I+p.S255N+p.D256E+p.S283G+p.R284G+p.D286N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included D6DE, K14R, S24N, L74I, T112IV, T124N, T125A, G134N, K136T, V201I, T206S, L234I, S255N, D256E, S283G, R284G, D286N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.V31I+p.K136N+p.V201I+p.I203IML+p.S230N+p.D256E+p.S283ST	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included V31I, K136N, V201I, I203IML, S230N, D256E, S283ST.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.E11D+p.A23V+p.L28I+p.V37I+p.L101I+p.V201VI+p.T206S+p.K215N+p.D232DE+p.D256E+p.S283G	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, A23V, L28I, V37I, L101I, V201VI, T206S, K215N, D232DE, D256E, S283G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.E11ED+p.V31I+p.L45I+p.L101I+p.S119P+p.I135V+p.F181L+p.T206S+p.K211R	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11ED, V31I, L45I, L101I, S119P, I135V, F181L, T206S, K211R.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.S17N+p.L28I+p.D41E+p.L45V+p.M50L+p.T112I+p.A128T+p.I220L+p.Q221H+p.N222T+p.D270H+p.R284G	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17N, L28I, D41E, L45V, M50L, T112I, A128T, I220L, Q221H, N222T, D270H, R284G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.I72IV+p.L74I+p.E96D+p.L101LI+p.D256DE	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72IV, L74I, E96D, L101LI, D256DE.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.E11D+p.S24N+p.L101I+p.I135V+p.K136T+p.Y194YH+p.T206S+p.I208L+p.T218S+p.S230N+p.D232DE	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, S24N, L101I, I135V, K136T, Y194YH, T206S, I208L, T218S, S230N, D232DE.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.E11D+p.A21AT+p.A23AV+p.D25E+p.K111T+p.I113IV+p.D278DG	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, A21AT, A23AV, D25E, K111T, I113IV, D278DG.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.S39C+p.M50I+p.L101I+p.S119P+p.M154L+p.K173KR+p.Q177QL+p.V201I+p.T206S+p.T218S	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S39C, M50I, L101I, S119P, M154L, K173KR, Q177QL, V201I, T206S, T218S.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.A21T+p.L45V+p.T124Q+p.T125V+p.I182V+p.D256E+p.R262L	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included A21T, L45V, T124Q, T125V, I182V, D256E, R262L.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.L45LV+p.L101I+p.G163E+p.V165VI+p.S195C+p.Q216H+p.K219Q+p.D278A	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included L45LV, L101I, G163E, V165VI, S195C, Q216H, K219Q, D278A.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.D25E+p.P90PS+p.T124TA+p.V201I+p.S230N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included D25E, P90PS, T124TA, V201I, S230N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.M50I+p.V151I+p.L234LF	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included M50I, V151I, L234LF.
Key Molecule: HIV1 Integrase (HIV1 IT)				[6]
Molecule Alteration	Missense mutation		p.S17N+p.L45V+p.I73V+p.P90S+p.L101I+p.T124N+p.G163H+p.I208L+p.I220L+p.D256E+p.S283G	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17N, L45V, I73V, P90S, L101I, T124N, G163H, I208L, I220L, D256E, S283G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[6]
Molecule Alteration	Missense mutation		p.S17C+p.G163E+p.K188R+p.K211R+p.Q216N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17C, G163E, K188R, K211R, Q216N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[7]
Molecule Alteration	Missense mutation		p.K14R+p.S24N+p.L101V+p.K111R+p.T112V+p.T124A+p.V126M+p.K160Q+p.D167DE+p.V201I+p.K211R+p.S230N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included K14R, S24N, L101V, K111R, T112V, T124A, V126M, K160Q, D167DE, V201I, K211R, S230N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[7]
Molecule Alteration	Missense mutation		p.D6E+p.E10D+p.M22MI+p.A23AV+p.T124N+p.V201I+p.D232E+p.D253DE+p.D256E	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included D6E, E10D, M22MI, A23AV, T124N, V201I, D232E, D253DE, D256E.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.E11D+p.V31I+p.M50TI+p.L101I+p.K111T+p.F181L+p.V201I+p.S283G	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, V31I, M50TI, L101I, K111T, F181L, V201I, S283G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.K14R+p.L28I+p.S39C+p.A91T+p.T124S+p.G193E+p.V201I+p.T218S+p.S230N+p.D279N+p.S283G	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included K14R, L28I, S39C, A91T, T124S, G193E, V201I, T218S, S230N, D279N, S283G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.E11D+p.S24N+p.N27NS+p.K34R+p.M50MI+p.L101I+p.S119P+p.T122TI+p.I135V+p.V165VI+p.K211R+p.D256E	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, S24N, N27NS, K34R, M50MI, L101I, S119P, T122TI, I135V, V165VI, K211R, D256E.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.S39C+p.I72IV+p.Y99H+p.V201I	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S39C, I72IV, Y99H, V201I.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.S17N+p.V31I+p.I60L+p.T124N+p.T125A+p.K173R+p.I182V+p.K215KN+p.Y227F+p.D253Y+p.D256E	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17N, V31I, I60L, T124N, T125A, K173R, I182V, K215KN, Y227F, D253Y, D256E.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.L2LP+p.E11D+p.K14R+p.V32I+p.V201I+p.I208L+p.E212A+p.D232E+p.L234F+p.S283SG	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included L2LP, E11D, K14R, V32I, V201I, I208L, E212A, D232E, L234F, S283SG.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.D6E+p.E10D+p.I72IV+p.A91S+p.S119G+p.T122I+p.T124A+p.T125A+p.I220L+p.Y227F+p.L234I	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included D6E, E10D, I72IV, A91S, S119G, T122I, T124A, T125A, I220L, Y227F, L234I.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.M50I+p.K173KR+p.K215N+p.I220L+p.D256E	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included M50I, K173KR, K215N, I220L, D256E.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.A8AV+p.E10D+p.S24A+p.L101I+p.K111T+p.S119T+p.T124X+p.T125A+p.K160R+p.K188R+p.G193E+p.D279G+p.D286N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included A8AV, E10D, S24A, L101I, K111T, S119T, T124X, T125A, K160R, K188R, G193E, D279G, D286N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.E11D+p.R20RK+p.S24SN+p.K34KR+p.I72IV+p.I84IM+p.A91AT+p.L101LI+p.T112TI+p.T125X+p.V151VI+p.V201I+p.S230SN+p.S283SG	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, R20RK, S24SN, K34KR, I72IV, I84IM, A91AT, L101LI, T112TI, T125X, V151VI, V201I, S230SN, S283SG.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.E10D+p.E11D+p.E35EK+p.I72IV+p.L101LI+p.T124TA+p.G193D+p.S195C+p.V201VI+p.T206S+p.I208L+p.E212A+p.N254Q+p.R269K+p.D286N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E10D, E11D, E35EK, I72IV, L101LI, T124TA, G193D, S195C, V201VI, T206S, I208L, E212A, N254Q, R269K, D286N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.E11D+p.S24N+p.S39C+p.T124TA+p.V201I+p.S230N+p.R284RG	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, S24N, S39C, T124TA, V201I, S230N, R284RG.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.S17N+p.K111KR+p.T125A+p.G193E+p.V201I+p.D232E+p.D286N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17N, K111KR, T125A, G193E, V201I, D232E, D286N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.A8AG+p.E11D+p.S24G+p.D25E+p.L28I+p.V37VI+p.S39C+p.K71KR+p.L101I+p.K215N+p.S230N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included A8AG, E11D, S24G, D25E, L28I, V37VI, S39C, K71KR, L101I, K215N, S230N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.L101I+p.T124A+p.V201I+p.T206TS+p.K211R+p.K215N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included L101I, T124A, V201I, T206TS, K211R, K215N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.E10D+p.V31I+p.M50T+p.L101I+p.K136Q+p.G163Q+p.K211R+p.S283G	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E10D, V31I, M50T, L101I, K136Q, G163Q, K211R, S283G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.S17N+p.L158LS+p.K219Q+p.I220L+p.S255K	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17N, L158LS, K219Q, I220L, S255K.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.S17N+p.V31VI+p.S57G+p.K111KR+p.T124N+p.T125TA+p.K211KQ+p.T218S+p.K219N+p.N222K+p.S230N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17N, V31VI, S57G, K111KR, T124N, T125TA, K211KQ, T218S, K219N, N222K, S230N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.E11D+p.R20K+p.L101I+p.I162IV+p.S195T+p.D278DN+p.S283SG	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, R20K, L101I, I162IV, S195T, D278DN, S283SG.
Key Molecule: HIV1 Integrase (HIV1 IT)				[6]
Molecule Alteration	Missense mutation		p.K14KR+p.S17N+p.S24D+p.D25E+p.L28LI+p.S39C+p.G59GE+p.L101I+p.T124N+p.T125TA+p.V165I+p.L234LI+p.D286N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included K14KR, S17N, S24D, D25E, L28LI, S39C, G59GE, L101I, T124N, T125TA, V165I, L234LI, D286N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[6]
Molecule Alteration	Missense mutation		p.S17N+p.V31I+p.L101I+p.T124N+p.I135V+p.G163E+p.K173R+p.V201I+p.A205S+p.S230N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17N, V31I, L101I, T124N, I135V, G163E, K173R, V201I, A205S, S230N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[6]
Molecule Alteration	Missense mutation		p.E11ED+p.R20K+p.L101I+p.K111T+p.T122I+p.T124A+p.V201I+p.R262RG+p.R263RG+p.R269RG+p.R284G+p.D286N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11ED, R20K, L101I, K111T, T122I, T124A, V201I, R262RG, R263RG, R269RG, R284G, D286N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[6]
Molecule Alteration	Missense mutation		p.E10D+p.K34R+p.I72IV+p.L101I+p.K111R+p.T112TI+p.T124N+p.T125A+p.A175T+p.V201I+p.K211R+p.S230N+p.S283G	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E10D, K34R, I72IV, L101I, K111R, T112TI, T124N, T125A, A175T, V201I, K211R, S230N, S283G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[6]
Molecule Alteration	Missense mutation		p.D6E+p.K14KR+p.A23AV+p.S24SG+p.P30PA+p.S39SC+p.I72IV+p.L74I+p.T124A+p.V201I+p.T206S+p.I208L+p.E212A+p.K215N+p.S283G	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included D6E, K14KR, A23AV, S24SG, P30PA, S39SC, I72IV, L74I, T124A, V201I, T206S, I208L, E212A, K215N, S283G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[6]
Molecule Alteration	Missense mutation		p.V31I+p.S39C+p.P90PS+p.E96EG+p.T124N+p.V201I+p.K215Q+p.T218S+p.S230N+p.D232E+p.L234H+p.D253E+p.N254D+p.C280CR	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included V31I, S39C, P90PS, E96EG, T124N, V201I, K215Q, T218S, S230N, D232E, L234H, D253E, N254D, C280CR.
Key Molecule: HIV1 Integrase (HIV1 IT)				[7]
Molecule Alteration	Missense mutation		p.S17N+p.V31I+p.V32I+p.S39C+p.L101I+p.T112I+p.T124N+p.V201I+p.A205S+p.T206S+p.K211R+p.S230N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17N, V31I, V32I, S39C, L101I, T112I, T124N, V201I, A205S, T206S, K211R, S230N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[7]
Molecule Alteration	Missense mutation		p.E11D+p.K14R+p.A21AT+p.T112V+p.T125A+p.G163T+p.S230X+p.D232DE+p.L234LF	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, K14R, A21AT, T112V, T125A, G163T, S230X, D232DE, L234LF.
Key Molecule: HIV1 Integrase (HIV1 IT)				[7]
Molecule Alteration	Missense mutation		p.V31I+p.M50I+p.T124A+p.K188KR+p.T206S+p.Y227F+p.A265V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included V31I, M50I, T124A, K188KR, T206S, Y227F, A265V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[7]
Molecule Alteration	Missense mutation		p.S17N+p.V31VIM+p.I72IT+p.I84IL+p.V88VL+p.T124S+p.T125TA+p.K156N+p.I203M+p.D256E	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17N, V31VIM, I72IT, I84IL, V88VL, T124S, T125TA, K156N, I203M, D256E.
Key Molecule: HIV1 Integrase (HIV1 IT)				[7]
Molecule Alteration	Missense mutation		p.D6E+p.E10D+p.E11D+p.K14R+p.V31I+p.M50T+p.I60L+p.K111Q+p.T124A+p.T206S	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included D6E, E10D, E11D, K14R, V31I, M50T, I60L, K111Q, T124A, T206S.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.E11D+p.V31I+p.P90PS+p.T112IV+p.I113IV+p.S119SG+p.T122I+p.A196P+p.V201I+p.K215KN+p.S230N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, V31I, P90PS, T112IV, I113IV, S119SG, T122I, A196P, V201I, K215KN, S230N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.K14KR+p.D41N+p.L45Q+p.L101I+p.T125A+p.F181L+p.V201I+p.K219N+p.N222K+p.S283G	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included K14KR, D41N, L45Q, L101I, T125A, F181L, V201I, K219N, N222K, S283G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.E11D+p.E13D+p.V31I+p.K71KR+p.L101I+p.S119P+p.T122I+p.T124TN+p.G163E+p.D256E	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, E13D, V31I, K71KR, L101I, S119P, T122I, T124TN, G163E, D256E.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.E11D+p.S24N+p.V31I+p.P58PT+p.K71KT+p.I72IV+p.I84IV+p.L101I+p.S119P+p.T122IV+p.T125A+p.I200IL+p.V201I+p.A205AT+p.I220L+p.D232E+p.S283SN	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, S24N, V31I, P58PT, K71KT, I72IV, I84IV, L101I, S119P, T122IV, T125A, I200IL, V201I, A205AT, I220L, D232E, S283SN.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.M50MIT+p.I72IV+p.T112I+p.T124TA+p.V201I+p.T206TS+p.K215KN	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included M50MIT, I72IV, T112I, T124TA, V201I, T206TS, K215KN.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.K14R+p.V32I+p.L101I+p.T124N+p.M154MI+p.N155NH+p.V201I+p.N222H+p.S230N+p.D256E	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included K14R, V32I, L101I, T124N, M154MI, N155NH, V201I, N222H, S230N, D256E.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.K7KR+p.E11D+p.D25E+p.L101I+p.K111R+p.S119P+p.T122I+p.T124A+p.M154L+p.D256E	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included K7KR, E11D, D25E, L101I, K111R, S119P, T122I, T124A, M154L, D256E.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.V31I+p.P90PS+p.T112AV+p.T124A+p.M154L+p.K211R+p.T218S+p.S230N+p.S283G	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included V31I, P90PS, T112AV, T124A, M154L, K211R, T218S, S230N, S283G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.K14R+p.S17N+p.N18D+p.A21T+p.T124A+p.S195C+p.I203M+p.S230N+p.L234LH+p.D278A+p.R284G	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included K14R, S17N, N18D, A21T, T124A, S195C, I203M, S230N, L234LH, D278A, R284G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[6]
Molecule Alteration	Missense mutation		p.E11D+p.M50I+p.S119P+p.T122I+p.S195T+p.V201I+p.T218I+p.A265V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, M50I, S119P, T122I, S195T, V201I, T218I, A265V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[6]
Molecule Alteration	Missense mutation		p.E11D+p.S119P+p.T122TI+p.K219T+p.I220L+p.D232E+p.L234F	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, S119P, T122TI, K219T, I220L, D232E, L234F.
Key Molecule: HIV1 Integrase (HIV1 IT)				[6]
Molecule Alteration	Missense mutation		p.S24T+p.V31VI+p.L101I+p.K111T+p.T112A+p.T124A+p.T125TA+p.I135V+p.I162IV+p.F181L+p.E212S+p.K215N+p.Q216H+p.T218S+p.S230N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S24T, V31VI, L101I, K111T, T112A, T124A, T125TA, I135V, I162IV, F181L, E212S, K215N, Q216H, T218S, S230N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[7]
Molecule Alteration	Missense mutation		p.S17N+p.K34R+p.G59GE+p.I72IV+p.T112TI+p.I113IV+p.S119P+p.T124N+p.T125A+p.K136KT+p.V201I+p.S230N+p.D256E+p.Q274QK+p.D278DA+p.S283SG+p.R284RG	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17N, K34R, G59GE, I72IV, T112TI, I113IV, S119P, T124N, T125A, K136KT, V201I, S230N, D256E, Q274QK, D278DA, S283SG, R284RG.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.R20RK+p.L101I+p.K103R+p.S119G+p.T122I+p.T124N+p.G193GE	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included R20RK, L101I, K103R, S119G, T122I, T124N, G193GE.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.E10D+p.T124N+p.T125A+p.I135IV+p.M154I+p.P261F+p.R262F	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E10D, T124N, T125A, I135IV, M154I, P261F, R262F.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.E11D+p.V31I+p.V37I+p.V88VI+p.L101I+p.I113L+p.T124N+p.T125A+p.V201I+p.D229DG+p.D288X	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, V31I, V37I, V88VI, L101I, I113L, T124N, T125A, V201I, D229DG, D288X.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.S39SC+p.M50I+p.S119P+p.T125A+p.M154L+p.D167E+p.V201I+p.K211R+p.T218I	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S39SC, M50I, S119P, T125A, M154L, D167E, V201I, K211R, T218I.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.E11ED+p.A21AT+p.V32VI+p.A33AT+p.G47GR+p.V88VI+p.A98AT+p.L101I+p.T112V+p.I113L	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11ED, A21AT, V32VI, A33AT, G47GR, V88VI, A98AT, L101I, T112V, I113L.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.R20RK+p.V31I+p.T112A+p.T124S+p.T125A+p.K127KR+p.V165I+p.A205S+p.E287EK	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included R20RK, V31I, T112A, T124S, T125A, K127KR, V165I, A205S, E287EK.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.V31I+p.T124TN+p.T125V+p.K156N+p.D167E	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included V31I, T124TN, T125V, K156N, D167E.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.E11D+p.R20KE+p.S39SG+p.D41N+p.G70GR+p.T112I+p.V151I+p.N155NH+p.V201I	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, R20KE, S39SG, D41N, G70GR, T112I, V151I, N155NH, V201I.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.K14KR+p.S17SN+p.V31VI+p.G106A+p.K111T+p.T124TA+p.E157Q+p.K160Q+p.V201I+p.D256E	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included K14KR, S17SN, V31VI, G106A, K111T, T124TA, E157Q, K160Q, V201I, D256E.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.E11D+p.A21AT+p.V31I+p.A91E+p.L101I+p.T112V+p.S119R+p.T122I+p.T206S+p.N254NS	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, A21AT, V31I, A91E, L101I, T112V, S119R, T122I, T206S, N254NS.
Key Molecule: HIV1 Integrase (HIV1 IT)				[6]
Molecule Alteration	Missense mutation		p.T124A+p.T210I+p.K211R+p.A265V+p.D279G	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included T124A, T210I, K211R, A265V, D279G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.D6E+p.S17N+p.E35Q+p.S39N+p.D55S+p.I72IV+p.L101I+p.T124A+p.F181L+p.V201I+p.I220L+p.R284G	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included D6E, S17N, E35Q, S39N, D55S, I72IV, L101I, T124A, F181L, V201I, I220L, R284G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.P30PL+p.L101LI+p.A105AT+p.K111TA+p.S119G+p.T122I+p.T125A+p.V201I	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included P30PL, L101LI, A105AT, K111TA, S119G, T122I, T125A, V201I.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.S24SN+p.T112A+p.T125A+p.F181FL+p.E212A+p.Q216H+p.T218S+p.K219N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S24SN, T112A, T125A, F181FL, E212A, Q216H, T218S, K219N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.K14KR+p.S17X+p.M50I+p.V54I+p.E96D+p.L101I+p.T112S+p.T124N+p.T125A+p.A179AT+p.D288X	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included K14KR, S17X, M50I, V54I, E96D, L101I, T112S, T124N, T125A, A179AT, D288X.
Key Molecule: HIV1 Integrase (HIV1 IT)				[6]
Molecule Alteration	Missense mutation		p.S17N+p.L28I+p.L45I+p.L101I+p.S119G+p.T122I+p.T124A+p.T125A+p.G163E+p.T218S	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17N, L28I, L45I, L101I, S119G, T122I, T124A, T125A, G163E, T218S.
Key Molecule: HIV1 Integrase (HIV1 IT)				[6]
Molecule Alteration	Missense mutation		p.E11D+p.K14R+p.S24N+p.D25E+p.M50I+p.T124A+p.T125A+p.I220L+p.I268L	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, K14R, S24N, D25E, M50I, T124A, T125A, I220L, I268L.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.K7KE+p.S17N+p.V31VI+p.T124A+p.K160N+p.F223FL+p.A282AT	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included K7KE, S17N, V31VI, T124A, K160N, F223FL, A282AT.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.P90S+p.E212A+p.K215N+p.I220L+p.S230SN	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included P90S, E212A, K215N, I220L, S230SN.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.E11ED+p.K14KR+p.A21T+p.M50I+p.A133AG+p.V176VL	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11ED, K14KR, A21T, M50I, A133AG, V176VL.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.E11D+p.A21T+p.V31I+p.A91X+p.L101I+p.T112X+p.S119R+p.T122IV+p.S123SC+p.T124TN+p.Q148QR+p.T206S+p.T218TS	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, A21T, V31I, A91X, L101I, T112X, S119R, T122IV, S123SC, T124TN, Q148QR, T206S, T218TS.
Key Molecule: HIV1 Integrase (HIV1 IT)				[6]
Molecule Alteration	Missense mutation		p.E11D+p.A21T+p.L101LI+p.K111Q+p.T112A+p.S119SG+p.T122TI+p.T125TA+p.A128AT	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, A21T, L101LI, K111Q, T112A, S119SG, T122TI, T125TA, A128AT.
Key Molecule: HIV1 Integrase (HIV1 IT)				[7]
Molecule Alteration	Missense mutation		p.S119R+p.T125S+p.G193E+p.L234I+p.N254S+p.S255G+p.D279G	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S119R, T125S, G193E, L234I, N254S, S255G, D279G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[7]
Molecule Alteration	Missense mutation		p.E10D+p.I72IV+p.L101I+p.S119P+p.T122I+p.T124N+p.T125S+p.T218S	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E10D, I72IV, L101I, S119P, T122I, T124N, T125S, T218S.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.E11D+p.S24N+p.D25E+p.V31I+p.I84M+p.Q95P+p.Y99F+p.L101I+p.T112A+p.S119P+p.K136N+p.K160R+p.V201I+p.I203M+p.I208L+p.T218S+p.L234H+p.D253E	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, S24N, D25E, V31I, I84M, Q95P, Y99F, L101I, T112A, S119P, K136N, K160R, V201I, I203M, I208L, T218S, L234H, D253E.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.S24G+p.L101I+p.T124A+p.S153A+p.M154I+p.I200M+p.V201I+p.Q216H+p.Q221R+p.D256E	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S24G, L101I, T124A, S153A, M154I, I200M, V201I, Q216H, Q221R, D256E.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.K14R+p.R20K+p.V31I+p.V32VA+p.A33AT+p.T97A+p.L101I+p.T112IV+p.T124A+p.T125A+p.G134N+p.I135V+p.G163Q+p.G193E+p.V201I+p.T206S+p.T218TI+p.Y227F+p.L234I+p.S255N+p.D256E+p.D279G+p.S283G	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included K14R, R20K, V31I, V32VA, A33AT, T97A, L101I, T112IV, T124A, T125A, G134N, I135V, G163Q, G193E, V201I, T206S, T218TI, Y227F, L234I, S255N, D256E, D279G, S283G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.V31I+p.M50MI+p.S119P+p.T122I+p.D256E	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included V31I, M50MI, S119P, T122I, D256E.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.K14R+p.Y99H+p.L101I+p.I135V+p.E157Q+p.G193D+p.S195C+p.A265V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included K14R, Y99H, L101I, I135V, E157Q, G193D, S195C, A265V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.K14KR+p.S17SN+p.V31I+p.D41DN+p.L101I+p.K111KR+p.T112V+p.T124A+p.T125A+p.G134N+p.I135V+p.K136T+p.M154MI+p.T206S+p.L234I+p.S283G	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included K14KR, S17SN, V31I, D41DN, L101I, K111KR, T112V, T124A, T125A, G134N, I135V, K136T, M154MI, T206S, L234I, S283G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.K7KR+p.L28I+p.P30S+p.S39C+p.L45LS+p.M50MT+p.L101LI+p.T112A+p.N117NS+p.V201I+p.I220L+p.D253E+p.S255SN	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included K7KR, L28I, P30S, S39C, L45LS, M50MT, L101LI, T112A, N117NS, V201I, I220L, D253E, S255SN.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.I89IV+p.L101I+p.V110VI+p.T124A+p.T125A+p.M154I+p.H171Y+p.R187K+p.T206S+p.K211R	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I89IV, L101I, V110VI, T124A, T125A, M154I, H171Y, R187K, T206S, K211R.
Key Molecule: HIV1 Integrase (HIV1 IT)				[7]
Molecule Alteration	Missense mutation		p.E10ED+p.A23V+p.N27D+p.M50I+p.A91T+p.Q95P+p.L101I+p.T112A+p.S119R+p.T125P+p.V201I+p.T206S+p.L241LF	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E10ED, A23V, N27D, M50I, A91T, Q95P, L101I, T112A, S119R, T125P, V201I, T206S, L241LF.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.V31I+p.L101I+p.G118GD+p.S119G+p.T122I+p.T124N+p.F181L+p.V201I+p.I220IL+p.S283G+p.R284G	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included V31I, L101I, G118GD, S119G, T122I, T124N, F181L, V201I, I220IL, S283G, R284G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.E11D+p.S24N+p.D25E+p.L68I+p.I73V+p.T124A+p.D167E+p.I220L	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, S24N, D25E, L68I, I73V, T124A, D167E, I220L.
Key Molecule: HIV1 Integrase (HIV1 IT)				[6]
Molecule Alteration	Missense mutation		p.E11D+p.M50MI+p.V88I+p.K111T+p.T112TI+p.S119P+p.T122TI+p.T125TA+p.V201I+p.T210TI+p.L234LF+p.L242LF	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, M50MI, V88I, K111T, T112TI, S119P, T122TI, T125TA, V201I, T210TI, L234LF, L242LF.
Key Molecule: HIV1 Integrase (HIV1 IT)				[7]
Molecule Alteration	Missense mutation		p.E11D+p.S17T+p.M50V+p.L101I+p.T112I+p.S119P+p.T124N+p.I135V+p.F181L+p.V201I+p.T206S+p.L242LF+p.A265V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, S17T, M50V, L101I, T112I, S119P, T124N, I135V, F181L, V201I, T206S, L242LF, A265V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[7]
Molecule Alteration	Missense mutation		p.E11D+p.D25E+p.V31I+p.M50I+p.M154L+p.V201I	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, D25E, V31I, M50I, M154L, V201I.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.V31I+p.L101I+p.S119G+p.T122I+p.T124N+p.F181L+p.V201I+p.I220IL+p.S283G+p.R284G	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included V31I, L101I, S119G, T122I, T124N, F181L, V201I, I220IL, S283G, R284G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.M50TI+p.G70D+p.L101I+p.I113IV+p.S119R+p.T124N+p.T125A+p.I135V+p.F181L+p.T206S+p.I251IV+p.D256E	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included M50TI, G70D, L101I, I113IV, S119R, T124N, T125A, I135V, F181L, T206S, I251IV, D256E.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.R20RK+p.V31I+p.E48EK+p.L101I+p.I113IV+p.S119ST+p.T125A+p.M154L+p.K173R+p.F181L+p.G193E+p.T206S+p.T210I+p.T218I+p.I220V+p.L234H+p.D279G	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included R20RK, V31I, E48EK, L101I, I113IV, S119ST, T125A, M154L, K173R, F181L, G193E, T206S, T210I, T218I, I220V, L234H, D279G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.S17N+p.V31I+p.M50MI+p.I72IV+p.L101I+p.T124A+p.K136KN+p.N155NH+p.E157Q+p.K160Q+p.D232E+p.A265V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17N, V31I, M50MI, I72IV, L101I, T124A, K136KN, N155NH, E157Q, K160Q, D232E, A265V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.E11D+p.V31VI+p.M50I+p.K111T+p.S119P+p.T124A+p.T206S	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, V31VI, M50I, K111T, S119P, T124A, T206S.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.K34R+p.T66TA+p.I72IV+p.L74MV+p.L101I+p.S119T+p.T206S+p.T218S+p.M275V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included K34R, T66TA, I72IV, L74MV, L101I, S119T, T206S, T218S, M275V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[7]
Molecule Alteration	Missense mutation		p.S17C+p.A23AT+p.M50I+p.L101I+p.T112R+p.T124A+p.T125A+p.E157Q+p.K160Q+p.K219N+p.N222K+p.S230SN	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17C, A23AT, M50I, L101I, T112R, T124A, T125A, E157Q, K160Q, K219N, N222K, S230SN.
Key Molecule: HIV1 Integrase (HIV1 IT)				[7]
Molecule Alteration	Missense mutation		p.E11D+p.S24N+p.N27S+p.A91T+p.E96D+p.L101I+p.S119R+p.T124S+p.T125A+p.I135IV+p.K156N+p.V165I+p.V201I+p.I208L+p.T210S+p.K211T+p.E212A+p.M275V+p.S283G	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, S24N, N27S, A91T, E96D, L101I, S119R, T124S, T125A, I135IV, K156N, V165I, V201I, I208L, T210S, K211T, E212A, M275V, S283G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[7]
Molecule Alteration	Missense mutation		p.D25DE+p.V31VI+p.L74I+p.G163E+p.H171Q	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included D25DE, V31VI, L74I, G163E, H171Q.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.E11D+p.V31VI+p.V32I+p.D41DN+p.L68V+p.I73V+p.Q95QR+p.L101LI+p.T125A+p.I135V+p.V201I+p.R284G	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, V31VI, V32I, D41DN, L68V, I73V, Q95QR, L101LI, T125A, I135V, V201I, R284G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.D6E+p.E11D+p.S17N+p.V31I+p.L63I+p.L74I+p.E96D+p.L101I+p.T112V+p.T124N+p.T125A+p.G134N+p.K136T+p.E157Q+p.K160N+p.V201I+p.T206S+p.K211R+p.L234I+p.R269K+p.S283G+p.D288N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included D6E, E11D, S17N, V31I, L63I, L74I, E96D, L101I, T112V, T124N, T125A, G134N, K136T, E157Q, K160N, V201I, T206S, K211R, L234I, R269K, S283G, D288N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.V31I+p.E92EQ+p.T112AV+p.T124S+p.T125A+p.K127KR+p.V165I+p.A205S	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included V31I, E92EQ, T112AV, T124S, T125A, K127KR, V165I, A205S.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.E11D+p.E13D+p.A21T+p.M50MI+p.T97TA+p.L101I+p.S119G+p.T122I+p.T124S+p.K136N+p.N155NH+p.D256E	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, E13D, A21T, M50MI, T97TA, L101I, S119G, T122I, T124S, K136N, N155NH, D256E.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.S17N+p.L28I+p.S39C+p.M50MI+p.T66TA+p.T124TA+p.S147SG+p.V201I+p.K211Q	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17N, L28I, S39C, M50MI, T66TA, T124TA, S147SG, V201I, K211Q.
Key Molecule: HIV1 Integrase (HIV1 IT)				[6]
Molecule Alteration	Missense mutation		p.D6DN+p.K14KR+p.S17N+p.S24D+p.D25E+p.L28LI+p.S39C+p.S57SG+p.T66TI+p.E92EQ+p.L101I+p.T124N+p.V165I+p.D286N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included D6DN, K14KR, S17N, S24D, D25E, L28LI, S39C, S57SG, T66TI, E92EQ, L101I, T124N, V165I, D286N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[6]
Molecule Alteration	Missense mutation		p.E11D+p.V31I+p.M50MT+p.G70E+p.T97A+p.L101I+p.T112I+p.S119R+p.T124N+p.D167E+p.V201I+p.T206S+p.I208L+p.E212A+p.T218S+p.K240KR+p.S255N+p.D256E+p.R284G	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, V31I, M50MT, G70E, T97A, L101I, T112I, S119R, T124N, D167E, V201I, T206S, I208L, E212A, T218S, K240KR, S255N, D256E, R284G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.K14R+p.S17SN+p.R20RK+p.V31I+p.D41DN+p.T66TI+p.E92EQ+p.L101I+p.T112V+p.T124A+p.T125A+p.G134N+p.I135V+p.K136T+p.R187RK+p.T206S+p.L234I+p.V249VI+p.S283G	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included K14R, S17SN, R20RK, V31I, D41DN, T66TI, E92EQ, L101I, T112V, T124A, T125A, G134N, I135V, K136T, R187RK, T206S, L234I, V249VI, S283G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.T66I+p.T112A+p.T125A+p.V126L+p.Q148QR+p.M154I+p.L234I	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included T66I, T112A, T125A, V126L, Q148QR, M154I, L234I.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.S17N+p.V31I+p.L101I+p.T122TI+p.T124S+p.T125A+p.I135IV+p.Y143X+p.N155NH+p.E198D+p.V201I+p.T206S+p.D232E+p.A265V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17N, V31I, L101I, T122TI, T124S, T125A, I135IV, Y143X, N155NH, E198D, V201I, T206S, D232E, A265V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.K14R+p.V31I+p.T124X+p.T125TA+p.N155H+p.K215N+p.S230N+p.R231K+p.D253E+p.N254Q+p.S255G+p.D256E+p.K258N+p.V259L+p.V260L	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included K14R, V31I, T124X, T125TA, N155H, K215N, S230N, R231K, D253E, N254Q, S255G, D256E, K258N, V259L, V260L.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.T66TA+p.L101LI+p.M154L+p.N155NH+p.V201I+p.D232DN	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included T66TA, L101LI, M154L, N155NH, V201I, D232DN.
Key Molecule: HIV1 Integrase (HIV1 IT)				[7]
Molecule Alteration	Missense mutation		p.K14R+p.S24N+p.C65CG+p.T66TI+p.E92EQ+p.L101V+p.K111R+p.T112V+p.T124A+p.V126M+p.N155NH+p.E157EQ+p.K160Q+p.D167E+p.V201I+p.K211R+p.S230N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included K14R, S24N, C65CG, T66TI, E92EQ, L101V, K111R, T112V, T124A, V126M, N155NH, E157EQ, K160Q, D167E, V201I, K211R, S230N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.E11D+p.A21T+p.M50I+p.E92G+p.S119P+p.T124A+p.K188KR+p.I208IM+p.D256E	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, A21T, M50I, E92G, S119P, T124A, K188KR, I208IM, D256E.
Key Molecule: HIV1 Integrase (HIV1 IT)				[7]
Molecule Alteration	Missense mutation		p.E10D+p.I72IV+p.L101I+p.S119P+p.T122I+p.T124N+p.T125S+p.Q148R+p.V165VI+p.T218S	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E10D, I72IV, L101I, S119P, T122I, T124N, T125S, Q148R, V165VI, T218S.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.E11D+p.A23V+p.L28I+p.V37I+p.D41DN+p.G70GR+p.T97TA+p.L101I+p.P142PT+p.V151VI+p.N155NH+p.E157EQ+p.V201VI+p.T206S+p.K215N+p.D232DE+p.D256E+p.S283G	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, A23V, L28I, V37I, D41DN, G70GR, T97TA, L101I, P142PT, V151VI, N155NH, E157EQ, V201VI, T206S, K215N, D232DE, D256E, S283G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[6]
Molecule Alteration	Missense mutation		p.E92Q+p.L101I+p.T112V+p.T210TI+p.I220V+p.L242LF+p.D253E+p.R284G	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E92Q, L101I, T112V, T210TI, I220V, L242LF, D253E, R284G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.S17N+p.R20RK+p.V31I+p.M50I+p.T66TI+p.E92EQ+p.T124A+p.N155NH+p.K156N+p.V165I+p.F181FL+p.V201I+p.S255K+p.I268L	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17N, R20RK, V31I, M50I, T66TI, E92EQ, T124A, N155NH, K156N, V165I, F181FL, V201I, S255K, I268L.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.V31I+p.I84M+p.E92Q+p.L101I+p.K111T+p.I135V+p.V201I+p.T206S+p.K211R+p.E212T+p.K219N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included V31I, I84M, E92Q, L101I, K111T, I135V, V201I, T206S, K211R, E212T, K219N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.S17N+p.K34R+p.K46KR+p.M50L+p.E92Q+p.T124A+p.T125A+p.V201I+p.A205S+p.T206S+p.I208L+p.K211RG+p.E212A	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17N, K34R, K46KR, M50L, E92Q, T124A, T125A, V201I, A205S, T206S, I208L, K211RG, E212A.
Key Molecule: HIV1 Integrase (HIV1 IT)				[6]
Molecule Alteration	Missense mutation		p.K14R+p.R20K+p.S24N+p.D25E+p.V31I+p.G59E+p.I60V+p.E92Q+p.L101I+p.T124A+p.T125A+p.D167DE+p.K215R+p.N222K	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included K14R, R20K, S24N, D25E, V31I, G59E, I60V, E92Q, L101I, T124A, T125A, D167DE, K215R, N222K.
Key Molecule: HIV1 Integrase (HIV1 IT)				[7]
Molecule Alteration	Missense mutation		p.E11D+p.S24SN+p.D25E+p.L101I+p.S119P+p.T122I+p.K136N+p.N155H+p.D279DN	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, S24SN, D25E, L101I, S119P, T122I, K136N, N155H, D279DN.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.E11D+p.A21T+p.L101I+p.T112V+p.I113L+p.N155H	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, A21T, L101I, T112V, I113L, N155H.
Key Molecule: HIV1 Integrase (HIV1 IT)				[7]
Molecule Alteration	Missense mutation		p.S17N+p.I84L+p.V88VL+p.E92Q+p.T124S+p.K156N+p.I203M+p.D256E	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17N, I84L, V88VL, E92Q, T124S, K156N, I203M, D256E.
Key Molecule: HIV1 Integrase (HIV1 IT)				[6]
Molecule Alteration	Missense mutation		p.M50I+p.E92Q+p.T125A+p.I135V+p.M154I+p.I162V+p.V201I+p.K215N+p.L234I	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included M50I, E92Q, T125A, I135V, M154I, I162V, V201I, K215N, L234I.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.S17N+p.M50I+p.E92EQ+p.E96EA+p.T124A+p.N155NH+p.G163E+p.V201I+p.D256DE	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17N, M50I, E92EQ, E96EA, T124A, N155NH, G163E, V201I, D256DE.
Key Molecule: HIV1 Integrase (HIV1 IT)				[6]
Molecule Alteration	Missense mutation		p.E11D+p.K14R+p.A21T+p.A23V+p.E92EQ+p.L101I+p.S119T+p.Q148QR+p.N155NH	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, K14R, A21T, A23V, E92EQ, L101I, S119T, Q148QR, N155NH.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.S17N+p.A49P+p.L101LF+p.T124A+p.S153SF+p.N155H+p.E170EA+p.H171HR+p.L172LF+p.G193E+p.V201I+p.T218S+p.I220LF+p.D232DN+p.L241LF+p.L242LF+p.D253E+p.S255R	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17N, A49P, L101LF, T124A, S153SF, N155H, E170EA, H171HR, L172LF, G193E, V201I, T218S, I220LF, D232DN, L241LF, L242LF, D253E, S255R.
Key Molecule: HIV1 Integrase (HIV1 IT)				[6]
Molecule Alteration	Missense mutation		p.E11D+p.M50I+p.S119P+p.T122I+p.N155H+p.S195T+p.V201I+p.T218I	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, M50I, S119P, T122I, N155H, S195T, V201I, T218I.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.L101I+p.N155H+p.K156N+p.I208L	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included L101I, N155H, K156N, I208L.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.S39C+p.Y99H+p.N155H+p.I162IV+p.G163GR+p.V201I+p.D232DN	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S39C, Y99H, N155H, I162IV, G163GR, V201I, D232DN.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.E11D+p.A23V+p.L28I+p.V37I+p.D41DN+p.T97TA+p.L101I+p.T112TA+p.S119SR+p.V151VI+p.N155H+p.E157EQ+p.V201I+p.T206S+p.K215N+p.D232DE+p.D256E+p.S283G	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, A23V, L28I, V37I, D41DN, T97TA, L101I, T112TA, S119SR, V151VI, N155H, E157EQ, V201I, T206S, K215N, D232DE, D256E, S283G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.E10D+p.V31VMI+p.L45LR+p.E92EQ+p.L101I+p.T112TI+p.T124TA+p.N155H+p.S230SR	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E10D, V31VMI, L45LR, E92EQ, L101I, T112TI, T124TA, N155H, S230SR.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.S24G+p.D25E+p.L28I+p.E35Q+p.L45V+p.T125A+p.G140S+p.Q148H+p.V201I+p.S230N+p.S283R+p.R284G	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S24G, D25E, L28I, E35Q, L45V, T125A, G140S, Q148H, V201I, S230N, S283R, R284G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.S17N+p.D25E+p.F26FL+p.M50I+p.L101I+p.S119SR+p.T124A+p.N155H+p.K156N+p.Q221S+p.N222K	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17N, D25E, F26FL, M50I, L101I, S119SR, T124A, N155H, K156N, Q221S, N222K.
Key Molecule: HIV1 Integrase (HIV1 IT)				[6]
Molecule Alteration	Missense mutation		p.E11D+p.K14R+p.S17T+p.S39C+p.H51HY+p.I60V+p.L68V+p.E92Q+p.T112I+p.T124A+p.T206S+p.E212A	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, K14R, S17T, S39C, H51HY, I60V, L68V, E92Q, T112I, T124A, T206S, E212A.
Key Molecule: HIV1 Integrase (HIV1 IT)				[6]
Molecule Alteration	Missense mutation		p.E11D+p.S17T+p.A23V+p.I73V+p.E92Q+p.T124A+p.S153A+p.G189GR+p.G193E+p.V201I+p.I208M+p.E212Y+p.Q216H+p.I220L	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, S17T, A23V, I73V, E92Q, T124A, S153A, G189GR, G193E, V201I, I208M, E212Y, Q216H, I220L.
Key Molecule: HIV1 Integrase (HIV1 IT)				[7]
Molecule Alteration	Missense mutation		p.K14R+p.S17N+p.K34R+p.G59E+p.S119P+p.T124N+p.T125A+p.G140C+p.Q148R+p.H183HP+p.V201I+p.S230N+p.D256E	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included K14R, S17N, K34R, G59E, S119P, T124N, T125A, G140C, Q148R, H183HP, V201I, S230N, D256E.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.D6E+p.E11D+p.S17N+p.V31I+p.L63I+p.L68LV+p.L74I+p.E92EQ+p.E96D+p.L101I+p.T112V+p.T124N+p.T125A+p.G134N+p.K136T+p.G140GA+p.Q148QR+p.E157Q+p.K160N+p.V201I+p.T206S+p.T210TI+p.K211R+p.L234I+p.R269K+p.S283G+p.D288N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included D6E, E11D, S17N, V31I, L63I, L68LV, L74I, E92EQ, E96D, L101I, T112V, T124N, T125A, G134N, K136T, G140GA, Q148QR, E157Q, K160N, V201I, T206S, T210TI, K211R, L234I, R269K, S283G, D288N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.D6E+p.E11D+p.S17N+p.V31I+p.L63I+p.L74I+p.E92EQ+p.E96D+p.L101I+p.T112V+p.T124N+p.T125A+p.G134N+p.K136T+p.E157Q+p.K160N+p.V201I+p.T206S+p.T210TI+p.K211R+p.L234I+p.R269K+p.S283G+p.D288N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included D6E, E11D, S17N, V31I, L63I, L74I, E92EQ, E96D, L101I, T112V, T124N, T125A, G134N, K136T, E157Q, K160N, V201I, T206S, T210TI, K211R, L234I, R269K, S283G, D288N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.E11D+p.S24N+p.K34R+p.I72IV+p.I84M+p.A91T+p.L101I+p.T125V+p.G140S+p.Q148H+p.I161T+p.V201I+p.K211KR+p.S230N+p.V260L+p.P261F+p.S283G	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, S24N, K34R, I72IV, I84M, A91T, L101I, T125V, G140S, Q148H, I161T, V201I, K211KR, S230N, V260L, P261F, S283G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.K14R+p.S17N+p.V31VI+p.I60M+p.L101I+p.T112V+p.T124A+p.I135V+p.E138D+p.G140S+p.Q148H+p.K188KR+p.V201I+p.R263RK+p.A265V+p.S283G+p.R284G+p.D286N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included K14R, S17N, V31VI, I60M, L101I, T112V, T124A, I135V, E138D, G140S, Q148H, K188KR, V201I, R263RK, A265V, S283G, R284G, D286N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.K111KT+p.G140S+p.Q148H+p.N254K+p.A265AV+p.S283G	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included K111KT, G140S, Q148H, N254K, A265AV, S283G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.S17SN+p.R20RK+p.N27G+p.L28I+p.L45Q+p.I72IV+p.P90PL+p.G140S+p.Q148H+p.Q216QH+p.D256DE+p.D279DG	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17SN, R20RK, N27G, L28I, L45Q, I72IV, P90PL, G140S, Q148H, Q216QH, D256DE, D279DG.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.V31I+p.K111T+p.S119G+p.T122I+p.T125A+p.G140S+p.Q148H+p.Q164QP+p.Q168QP+p.H171HP+p.R231K+p.D288N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included V31I, K111T, S119G, T122I, T125A, G140S, Q148H, Q164QP, Q168QP, H171HP, R231K, D288N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.E10D+p.V31I+p.M50T+p.L101I+p.S119R+p.K136Q+p.N155H+p.G163Q+p.K211R+p.I217IV+p.S283G	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E10D, V31I, M50T, L101I, S119R, K136Q, N155H, G163Q, K211R, I217IV, S283G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[9]
Molecule Alteration	Missense mutation		p.Y143C	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included Y143C.
Key Molecule: HIV1 Integrase (HIV1 IT)				[9]
Molecule Alteration	Missense mutation		p.Y143H	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included Y143H.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.I113V+p.Y143H+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, I113V, Y143H, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.I113V+p.Y143C+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, I113V, Y143C, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.I113V+p.Y143C+p.G163R+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, I113V, Y143C, G163R, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[11]
Molecule Alteration	Missense mutation		p.E10D+p.L68V+p.I72V+p.S123G+p.T124A+p.K127R+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E10D, L68V, I72V, S123G, T124A, K127R, D232N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.I113V+p.Y143S+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, I113V, Y143S, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.I113V+p.Y143H+p.G163R+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, I113V, Y143H, G163R, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.L74M+p.I113V+p.Y143H+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, L74M, I113V, Y143H, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[12]
Molecule Alteration	Missense mutation		p.H51Y+p.I72V+p.I113V+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included H51Y, I72V, I113V, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.I113V+p.Y143G+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, I113V, Y143G, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[9]
Molecule Alteration	Missense mutation		p.Y143R	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included Y143R.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.L74M+p.I113V+p.Y143C+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, L74M, I113V, Y143C, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.L74I+p.I113V+p.Y143C+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, L74I, I113V, Y143C, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.L74I+p.I113V+p.Y143H+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, L74I, I113V, Y143H, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.I113V+p.Y143S+p.G163R+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, I113V, Y143S, G163R, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[9]
Molecule Alteration	Missense mutation		p.T97A	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included T97A.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.I113V+p.Y143H+p.S230R+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, I113V, Y143H, S230R, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.I113V+p.Y143A+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, I113V, Y143A, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.T97A+p.I113V+p.Y143H+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, T97A, I113V, Y143H, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.L74M+p.I113V+p.Y143S+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, L74M, I113V, Y143S, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.T97A+p.I113V+p.Y143C+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, T97A, I113V, Y143C, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.L74M+p.T97A+p.I113V+p.Y143C+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, L74M, T97A, I113V, Y143C, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.I113V+p.Y143R+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, I113V, Y143R, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.I113V+p.Y143R+p.G163R+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, I113V, Y143R, G163R, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.L74I+p.I113V+p.Y143S+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, L74I, I113V, Y143S, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.L74M+p.I113V+p.Y143G+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, L74M, I113V, Y143G, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[12]
Molecule Alteration	Missense mutation		p.I72V+p.I113V+p.L234V+p.R263K	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, I113V, L234V, R263K.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.L74I+p.I113V+p.Y143G+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, L74I, I113V, Y143G, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.I113V+p.Y143G+p.G163R+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, I113V, Y143G, G163R, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.T97A+p.I113V+p.Y143S+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, T97A, I113V, Y143S, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.L74M+p.T97A+p.I113V+p.Y143H+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, L74M, T97A, I113V, Y143H, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.L74M+p.I113V+p.Y143A+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, L74M, I113V, Y143A, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.T97A+p.I113V+p.Y143G+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, T97A, I113V, Y143G, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[11]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.S123G+p.T124A+p.K127R+p.G140S+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E10D, I72V, S123G, T124A, K127R, G140S, D232N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.L74M+p.I113V+p.Y143R+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, L74M, I113V, Y143R, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.L74I+p.I113V+p.Y143A+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, L74I, I113V, Y143A, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[9]
Molecule Alteration	Missense mutation		p.S147G	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S147G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.L74I+p.T97A+p.I113V+p.Y143C+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, L74I, T97A, I113V, Y143C, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.L74I+p.I113V+p.Y143R+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, L74I, I113V, Y143R, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.T97A+p.I113V+p.Y143H+p.G163R+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, T97A, I113V, Y143H, G163R, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.L74I+p.T97A+p.I113V+p.Y143H+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, L74I, T97A, I113V, Y143H, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.I113V+p.Y143R+p.S230R+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, I113V, Y143R, S230R, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.I113V+p.Y143C+p.S230R+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, I113V, Y143C, S230R, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.I113V+p.Y143A+p.G163R+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, I113V, Y143A, G163R, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.T97A+p.I113V+p.Y143C+p.G163R+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, T97A, I113V, Y143C, G163R, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[9]
Molecule Alteration	Missense mutation		p.Q148H	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included Q148H.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.L74M+p.T97A+p.I113V+p.Y143S+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, L74M, T97A, I113V, Y143S, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[11]
Molecule Alteration	Missense mutation		p.I72V+p.I113V+p.G140S+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, I113V, G140S, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.T97A+p.I113V+p.Y143H+p.S230R+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, T97A, I113V, Y143H, S230R, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.L74I+p.T97A+p.I113V+p.Y143S+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, L74I, T97A, I113V, Y143S, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.T97A+p.I113V+p.Y143S+p.G163R+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, T97A, I113V, Y143S, G163R, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[11]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.S123G+p.T124A+p.K127R+p.Q148H+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E10D, I72V, S123G, T124A, K127R, Q148H, D232N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.I113V+p.Y143S+p.S230R+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, I113V, Y143S, S230R, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[11]
Molecule Alteration	Missense mutation		p.I72V+p.I113V+p.Q148H+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, I113V, Q148H, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.L74M+p.T97A+p.I113V+p.Y143G+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, L74M, T97A, I113V, Y143G, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.L74I+p.T97A+p.I113V+p.Y143H+p.S230R+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, L74I, T97A, I113V, Y143H, S230R, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.I113V+p.Y143G+p.S230R+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, I113V, Y143G, S230R, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.T97A+p.I113V+p.Y143A+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, T97A, I113V, Y143A, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[9]
Molecule Alteration	Missense mutation		p.T66A	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included T66A.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.L74M+p.T97A+p.I113V+p.Y143A+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, L74M, T97A, I113V, Y143A, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.T97A+p.I113V+p.Y143R+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, T97A, I113V, Y143R, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[11]
Molecule Alteration	Missense mutation		p.I72V+p.I113V+p.S147G+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, I113V, S147G, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.L74I+p.T97A+p.I113V+p.Y143G+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, L74I, T97A, I113V, Y143G, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.L74M+p.T97A+p.I113V+p.Y143H+p.S230R+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, L74M, T97A, I113V, Y143H, S230R, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[9]
Molecule Alteration	Missense mutation		p.E92G	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E92G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.I113V+p.Y143A+p.S230R+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, I113V, Y143A, S230R, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[11]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.S123G+p.T124A+p.K127R+p.S147G+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E10D, I72V, S123G, T124A, K127R, S147G, D232N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[9]
Molecule Alteration	Missense mutation		p.T66I	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included T66I.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.L74I+p.T97A+p.I113V+p.Y143A+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, L74I, T97A, I113V, Y143A, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[11]
Molecule Alteration	Missense mutation		p.T66I+p.I72V+p.I113V+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included T66I, I72V, I113V, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[9]
Molecule Alteration	Missense mutation		p.E92Q	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E92Q.
Key Molecule: HIV1 Integrase (HIV1 IT)				[9]
Molecule Alteration	Missense mutation		p.N155H	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included N155H.
Key Molecule: HIV1 Integrase (HIV1 IT)				[11]
Molecule Alteration	Missense mutation		p.I72V+p.E92Q+p.I113V+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, E92Q, I113V, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[11]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.S123G+p.T124A+p.K127R+p.N155H+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E10D, I72V, S123G, T124A, K127R, N155H, D232N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[11]
Molecule Alteration	Missense mutation		p.I72V+p.I113V+p.N155H+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, I113V, N155H, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[9]
Molecule Alteration	Missense mutation		p.T66K	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included T66K.
Key Molecule: HIV1 Integrase (HIV1 IT)				[11]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.E92Q+p.S123G+p.T124A+p.K127R+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E10D, I72V, E92Q, S123G, T124A, K127R, D232N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[12]
Molecule Alteration	Missense mutation		p.H51Y+p.I72V+p.I113V+p.L234V+p.R263K	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included H51Y, I72V, I113V, L234V, R263K.
Key Molecule: HIV1 Integrase (HIV1 IT)				[11]
Molecule Alteration	Missense mutation		p.E10D+p.L68I+p.I72V+p.E92Q+p.S123G+p.T124A+p.K127R+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E10D, L68I, I72V, E92Q, S123G, T124A, K127R, D232N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[11]
Molecule Alteration	Missense mutation		p.T66I+p.I72V+p.I113V+p.S147G+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included T66I, I72V, I113V, S147G, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[11]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.S123G+p.T124A+p.K127R+p.Q148K+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E10D, I72V, S123G, T124A, K127R, Q148K, D232N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[11]
Molecule Alteration	Missense mutation		p.E10D+p.L68V+p.I72V+p.S123G+p.T124A+p.K127R+p.N155H+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E10D, L68V, I72V, S123G, T124A, K127R, N155H, D232N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[11]
Molecule Alteration	Missense mutation		p.I72V+p.I113V+p.Q148K+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, I113V, Q148K, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[11]
Molecule Alteration	Missense mutation		p.E10D+p.L68V+p.I72V+p.E92Q+p.S123G+p.T124A+p.K127R+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E10D, L68V, I72V, E92Q, S123G, T124A, K127R, D232N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[9]
Molecule Alteration	Missense mutation		p.Q148R	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included Q148R.
Key Molecule: HIV1 Integrase (HIV1 IT)				[9]
Molecule Alteration	Missense mutation		p.Q148K	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included Q148K.
Key Molecule: HIV1 Integrase (HIV1 IT)				[9]
Molecule Alteration	Missense mutation		p.T66I+p.E92Q	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included T66I, E92Q.
Key Molecule: HIV1 Integrase (HIV1 IT)				[9]
Molecule Alteration	Missense mutation		p.T66I+p.Q148R	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included T66I, Q148R.
Key Molecule: HIV1 Integrase (HIV1 IT)				[9]
Molecule Alteration	Missense mutation		p.T66I+p.N155H	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included T66I, N155H.
Key Molecule: HIV1 Integrase (HIV1 IT)				[9]
Molecule Alteration	Missense mutation		p.E92Q+p.Q148R	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E92Q, Q148R.
Key Molecule: HIV1 Integrase (HIV1 IT)				[9]
Molecule Alteration	Missense mutation		p.E92Q+p.N155H	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E92Q, N155H.
Key Molecule: HIV1 Integrase (HIV1 IT)				[9]
Molecule Alteration	Missense mutation		p.Q148R+p.N155H	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included Q148R, N155H.
Key Molecule: HIV1 Integrase (HIV1 IT)				[11]
Molecule Alteration	Missense mutation		p.I72V+p.I113V+p.Q148R+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, I113V, Q148R, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[11]
Molecule Alteration	Missense mutation		p.T66I+p.I72V+p.E92Q+p.I113V+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included T66I, I72V, E92Q, I113V, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[11]
Molecule Alteration	Missense mutation		p.I72V+p.E92Q+p.I113V+p.N155H+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, E92Q, I113V, N155H, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[11]
Molecule Alteration	Missense mutation		p.I72V+p.I113V+p.G140S+p.Q148H+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, I113V, G140S, Q148H, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[11]
Molecule Alteration	Missense mutation		p.I72V+p.I113V+p.E138K+p.S147G+p.Q148R+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, I113V, E138K, S147G, Q148R, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[11]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.S123G+p.T124A+p.K127R+p.Q148R+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E10D, I72V, S123G, T124A, K127R, Q148R, D232N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[11]
Molecule Alteration	Missense mutation		p.E10D+p.L68V+p.I72V+p.S123G+p.T124A+p.K127R+p.Q148R+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E10D, L68V, I72V, S123G, T124A, K127R, Q148R, D232N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[11]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.S123G+p.T124A+p.K127R+p.G140S+p.Q148H+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E10D, I72V, S123G, T124A, K127R, G140S, Q148H, D232N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[11]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.S123G+p.T124A+p.K127R+p.E138K+p.S147G+p.Q148R+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E10D, I72V, S123G, T124A, K127R, E138K, S147G, Q148R, D232N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[11]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.E92Q+p.S123G+p.T124A+p.K127R+p.N155H+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E10D, I72V, E92Q, S123G, T124A, K127R, N155H, D232N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[11]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.S123G+p.T124A+p.K127R+p.Q148R+p.N155H+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E10D, I72V, S123G, T124A, K127R, Q148R, N155H, D232N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.T97A+p.I113V+p.Y143G+p.G163R+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, T97A, I113V, Y143G, G163R, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.T97A+p.I113V+p.Y143A+p.G163R+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, T97A, I113V, Y143A, G163R, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.L74M+p.T97A+p.I113V+p.Y143R+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, L74M, T97A, I113V, Y143R, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.T97A+p.I113V+p.Y143C+p.S230R+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, T97A, I113V, Y143C, S230R, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.T97A+p.I113V+p.Y143S+p.S230R+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, T97A, I113V, Y143S, S230R, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.L74I+p.T97A+p.I113V+p.Y143R+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, L74I, T97A, I113V, Y143R, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.L74M+p.T97A+p.I113V+p.Y143C+p.S230R+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, L74M, T97A, I113V, Y143C, S230R, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.L74I+p.T97A+p.I113V+p.Y143R+p.S230R+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, L74I, T97A, I113V, Y143R, S230R, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.T97A+p.I113V+p.Y143R+p.G163R+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, T97A, I113V, Y143R, G163R, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.L74I+p.T97A+p.I113V+p.Y143C+p.S230R+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, L74I, T97A, I113V, Y143C, S230R, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.T97A+p.I113V+p.Y143R+p.S230R+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, T97A, I113V, Y143R, S230R, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.L74M+p.T97A+p.I113V+p.Y143R+p.S230R+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, L74M, T97A, I113V, Y143R, S230R, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.L74I+p.T97A+p.I113V+p.Y143S+p.S230R+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, L74I, T97A, I113V, Y143S, S230R, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.T97A+p.I113V+p.Y143G+p.S230R+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, T97A, I113V, Y143G, S230R, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.L74M+p.T97A+p.I113V+p.Y143S+p.S230R+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, L74M, T97A, I113V, Y143S, S230R, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.T97A+p.I113V+p.Y143A+p.S230R+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, T97A, I113V, Y143A, S230R, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.L74I+p.T97A+p.I113V+p.Y143G+p.S230R+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, L74I, T97A, I113V, Y143G, S230R, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.L74M+p.T97A+p.I113V+p.Y143G+p.S230R+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, L74M, T97A, I113V, Y143G, S230R, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.L74M+p.T97A+p.I113V+p.Y143A+p.S230R+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, L74M, T97A, I113V, Y143A, S230R, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[10]
Molecule Alteration	Missense mutation		p.I72V+p.L74I+p.T97A+p.I113V+p.Y143A+p.S230R+p.L234V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, L74I, T97A, I113V, Y143A, S230R, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[13]
Molecule Alteration	Missense mutation		p.L74M	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included L74M.
Key Molecule: HIV1 Integrase (HIV1 IT)				[13]
Molecule Alteration	Missense mutation		p.NULL	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included NULL.
Key Molecule: HIV1 Integrase (HIV1 IT)				[14]
Molecule Alteration	Missense mutation		p.A91E	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included A91E.
Key Molecule: HIV1 Integrase (HIV1 IT)				[15]
Molecule Alteration	Missense mutation		p.Y143C	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included Y143C.
Key Molecule: HIV1 Integrase (HIV1 IT)				[15]
Molecule Alteration	Missense mutation		p.Y143H	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included Y143H.
Key Molecule: HIV1 Integrase (HIV1 IT)				[15]
Molecule Alteration	Missense mutation		p.E138K	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E138K.
Key Molecule: HIV1 Integrase (HIV1 IT)				[13]
Molecule Alteration	Missense mutation		p.L234F	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included L234F.
Key Molecule: HIV1 Integrase (HIV1 IT)				[15]
Molecule Alteration	Missense mutation		p.E138A	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E138A.
Key Molecule: HIV1 Integrase (HIV1 IT)				[15]
Molecule Alteration	Missense mutation		p.E157K	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E157K.
Key Molecule: HIV1 Integrase (HIV1 IT)				[14]
Molecule Alteration	Missense mutation		p.T122I	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included T122I.
Key Molecule: HIV1 Integrase (HIV1 IT)				[15]
Molecule Alteration	Missense mutation		p.S119G	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S119G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[15]
Molecule Alteration	Missense mutation		p.M50I	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included M50I.
Key Molecule: HIV1 Integrase (HIV1 IT)				[15]
Molecule Alteration	Missense mutation		p.A128T	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included A128T.
Key Molecule: HIV1 Integrase (HIV1 IT)				[15]
Molecule Alteration	Missense mutation		p.G163K	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included G163K.
Key Molecule: HIV1 Integrase (HIV1 IT)				[15]
Molecule Alteration	Missense mutation		p.S119T	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S119T.
Key Molecule: HIV1 Integrase (HIV1 IT)				[15]
Molecule Alteration	Missense mutation		p.E170A	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E170A.
Key Molecule: HIV1 Integrase (HIV1 IT)				[14]
Molecule Alteration	Missense mutation		p.T122I	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included T122I.
Key Molecule: HIV1 Integrase (HIV1 IT)				[14]
Molecule Alteration	Missense mutation		p.L74I	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included L74I.
Key Molecule: HIV1 Integrase (HIV1 IT)				[15]
Molecule Alteration	Missense mutation		p.Q95R	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included Q95R.
Key Molecule: HIV1 Integrase (HIV1 IT)				[15]
Molecule Alteration	Missense mutation		p.L74M	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included L74M.
Key Molecule: HIV1 Integrase (HIV1 IT)				[15]
Molecule Alteration	Missense mutation		p.L68V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included L68V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[14]
Molecule Alteration	Missense mutation		p.NULL	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included NULL.
Key Molecule: HIV1 Integrase (HIV1 IT)				[14]
Molecule Alteration	Missense mutation		p.T97I	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included T97I.
Key Molecule: HIV1 Integrase (HIV1 IT)				[15]
Molecule Alteration	Missense mutation		p.G163R	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included G163R.
Key Molecule: HIV1 Integrase (HIV1 IT)				[15]
Molecule Alteration	Missense mutation		p.E157Q	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E157Q.
Key Molecule: HIV1 Integrase (HIV1 IT)				[15]
Molecule Alteration	Missense mutation		p.S153A	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S153A.
Key Molecule: HIV1 Integrase (HIV1 IT)				[15]
Molecule Alteration	Missense mutation		p.Q95K	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included Q95K.
Key Molecule: HIV1 Integrase (HIV1 IT)				[15]
Molecule Alteration	Missense mutation		p.L68I	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included L68I.
Key Molecule: HIV1 Integrase (HIV1 IT)				[15]
Molecule Alteration	Missense mutation		p.S119P	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S119P.
Key Molecule: HIV1 Integrase (HIV1 IT)				[14]
Molecule Alteration	Missense mutation		p.G70R	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included G70R.
Key Molecule: HIV1 Integrase (HIV1 IT)				[14]
Molecule Alteration	Missense mutation		p.T97S	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included T97S.
Key Molecule: HIV1 Integrase (HIV1 IT)				[13]
Molecule Alteration	Missense mutation		p.S153Y	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S153Y.
Key Molecule: HIV1 Integrase (HIV1 IT)				[15]
Molecule Alteration	Missense mutation		p.S119R	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S119R.
Key Molecule: HIV1 Integrase (HIV1 IT)				[15]
Molecule Alteration	Missense mutation		p.Y143R	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included Y143R.
Key Molecule: HIV1 Integrase (HIV1 IT)				[13]
Molecule Alteration	Missense mutation		p.S153F	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S153F.
Key Molecule: HIV1 Integrase (HIV1 IT)				[15]
Molecule Alteration	Missense mutation		p.Q146K	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included Q146K.
Key Molecule: HIV1 Integrase (HIV1 IT)				[14]
Molecule Alteration	Missense mutation		p.L74M	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included L74M.
Key Molecule: HIV1 Integrase (HIV1 IT)				[14]
Molecule Alteration	Missense mutation		p.L74M+p.S119P	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included L74M, S119P.
Key Molecule: HIV1 Integrase (HIV1 IT)				[13]
Molecule Alteration	Missense mutation		p.G140E	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included G140E.
Key Molecule: HIV1 Integrase (HIV1 IT)				[13]
Molecule Alteration	Missense mutation		p.S153Y	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S153Y.
Key Molecule: HIV1 Integrase (HIV1 IT)				[15]
Molecule Alteration	Missense mutation		p.I72T	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72T.
Key Molecule: HIV1 Integrase (HIV1 IT)				[16]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.S123G+p.T124A+p.K127R+p.E157Q+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E10D, I72V, S123G, T124A, K127R, E157Q, D232N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[13]
Molecule Alteration	Missense mutation		p.R263K	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included R263K.
Key Molecule: HIV1 Integrase (HIV1 IT)				[15]
Molecule Alteration	Missense mutation		p.S153F	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S153F.
Key Molecule: HIV1 Integrase (HIV1 IT)				[15]
Molecule Alteration	Missense mutation		p.V151A	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included V151A.
Key Molecule: HIV1 Integrase (HIV1 IT)				[14]
Molecule Alteration	Missense mutation		p.L74M+p.S119R	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included L74M, S119R.
Key Molecule: HIV1 Integrase (HIV1 IT)				[14]
Molecule Alteration	Missense mutation		p.T97V	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included T97V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[13]
Molecule Alteration	Missense mutation		p.G140A	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included G140A.
Key Molecule: HIV1 Integrase (HIV1 IT)				[15]
Molecule Alteration	Missense mutation		p.H51Y	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included H51Y.
Key Molecule: HIV1 Integrase (HIV1 IT)				[14]
Molecule Alteration	Missense mutation		p.T97A+p.G163R	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included T97A, G163R.
Key Molecule: HIV1 Integrase (HIV1 IT)				[15]
Molecule Alteration	Missense mutation		p.T97A	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included T97A.
Key Molecule: HIV1 Integrase (HIV1 IT)				[13]
Molecule Alteration	Missense mutation		p.S153Y+p.L234F	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S153Y, L234F.
Key Molecule: HIV1 Integrase (HIV1 IT)				[15]
Molecule Alteration	Missense mutation		p.S153Y	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S153Y.
Key Molecule: HIV1 Integrase (HIV1 IT)				[13]
Molecule Alteration	Missense mutation		p.I72A	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72A.
Key Molecule: HIV1 Integrase (HIV1 IT)				[13]
Molecule Alteration	Missense mutation		p.S147G	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S147G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[14]
Molecule Alteration	Missense mutation		p.M50I+p.T97A	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included M50I, T97A.
Key Molecule: HIV1 Integrase (HIV1 IT)				[14]
Molecule Alteration	Missense mutation		p.L74I+p.T97A	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included L74I, T97A.
Key Molecule: HIV1 Integrase (HIV1 IT)				[14]
Molecule Alteration	Missense mutation		p.T97A	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included T97A.
Key Molecule: HIV1 Integrase (HIV1 IT)				[14]
Molecule Alteration	Missense mutation		p.L74M+p.S119R	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included L74M, S119R.
Key Molecule: HIV1 Integrase (HIV1 IT)				[16]
Molecule Alteration	Missense mutation		p.E10D+p.H51Y+p.I72V+p.S123G+p.T124A+p.K127R+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E10D, H51Y, I72V, S123G, T124A, K127R, D232N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[14]
Molecule Alteration	Missense mutation		p.T97A+p.G118R+p.S119R	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included T97A, G118R, S119R.
Key Molecule: HIV1 Integrase (HIV1 IT)				[15]
Molecule Alteration	Missense mutation		p.S147G	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S147G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[15]
Molecule Alteration	Missense mutation		p.I72A	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72A.
Key Molecule: HIV1 Integrase (HIV1 IT)				[16]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.S123G+p.T124A+p.K127R+p.S153Y+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E10D, I72V, S123G, T124A, K127R, S153Y, D232N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[15]
Molecule Alteration	Missense mutation		p.R263K	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included R263K.
Key Molecule: HIV1 Integrase (HIV1 IT)				[14]
Molecule Alteration	Missense mutation		p.L74M+p.T97A	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included L74M, T97A.
Key Molecule: HIV1 Integrase (HIV1 IT)				[14]
Molecule Alteration	Missense mutation		p.L74M+p.T97A	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included L74M, T97A.
Key Molecule: HIV1 Integrase (HIV1 IT)				[14]
Molecule Alteration	Missense mutation		p.G118R	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included G118R.
Key Molecule: HIV1 Integrase (HIV1 IT)				[15]
Molecule Alteration	Missense mutation		p.Q146R	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included Q146R.
Key Molecule: HIV1 Integrase (HIV1 IT)				[15]
Molecule Alteration	Missense mutation		p.Q148H	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included Q148H.
Key Molecule: HIV1 Integrase (HIV1 IT)				[16]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.S123G+p.T124A+p.K127R+p.D232N+p.R263K	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E10D, I72V, S123G, T124A, K127R, D232N, R263K.
Key Molecule: HIV1 Integrase (HIV1 IT)				[15]
Molecule Alteration	Missense mutation		p.G140S	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included G140S.
Key Molecule: HIV1 Integrase (HIV1 IT)				[14]
Molecule Alteration	Missense mutation		p.T97A+p.S119T	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included T97A, S119T.
Key Molecule: HIV1 Integrase (HIV1 IT)				[15]
Molecule Alteration	Missense mutation		p.G140A	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included G140A.
Key Molecule: HIV1 Integrase (HIV1 IT)				[14]
Molecule Alteration	Missense mutation		p.T97A+p.S119G	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included T97A, S119G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[15]
Molecule Alteration	Missense mutation		p.G140C	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included G140C.
Key Molecule: HIV1 Integrase (HIV1 IT)				[15]
Molecule Alteration	Missense mutation		p.I72N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[15]
Molecule Alteration	Missense mutation		p.Q146P	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included Q146P.
Key Molecule: HIV1 Integrase (HIV1 IT)				[15]
Molecule Alteration	Missense mutation		p.T66A	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included T66A.
Key Molecule: HIV1 Integrase (HIV1 IT)				[14]
Molecule Alteration	Missense mutation		p.L74M+p.T97A+p.S119T	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included L74M, T97A, S119T.
Key Molecule: HIV1 Integrase (HIV1 IT)				[16]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.S123G+p.T124A+p.K127R+p.S147G+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E10D, I72V, S123G, T124A, K127R, S147G, D232N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[14]
Molecule Alteration	Missense mutation		p.T97A+p.G118R	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included T97A, G118R.
Key Molecule: HIV1 Integrase (HIV1 IT)				[13]
Molecule Alteration	Missense mutation		p.T66I	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included T66I.
Key Molecule: HIV1 Integrase (HIV1 IT)				[14]
Molecule Alteration	Missense mutation		p.L74M+p.T97A+p.S119G	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included L74M, T97A, S119G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[15]
Molecule Alteration	Missense mutation		p.E92G	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E92G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[14]
Molecule Alteration	Missense mutation		p.T97A+p.S119P	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included T97A, S119P.
Key Molecule: HIV1 Integrase (HIV1 IT)				[15]
Molecule Alteration	Missense mutation		p.T66I	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included T66I.
Key Molecule: HIV1 Integrase (HIV1 IT)				[16]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.F121Y+p.S123G+p.T124A+p.K127R+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E10D, I72V, F121Y, S123G, T124A, K127R, D232N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[14]
Molecule Alteration	Missense mutation		p.T97A+p.S119R	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included T97A, S119R.
Key Molecule: HIV1 Integrase (HIV1 IT)				[16]
Molecule Alteration	Missense mutation		p.E10D+p.T66I+p.I72V+p.S123G+p.T124A+p.K127R+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E10D, T66I, I72V, S123G, T124A, K127R, D232N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[15]
Molecule Alteration	Missense mutation		p.Q146L	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included Q146L.
Key Molecule: HIV1 Integrase (HIV1 IT)				[15]
Molecule Alteration	Missense mutation		p.F121Y	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included F121Y.
Key Molecule: HIV1 Integrase (HIV1 IT)				[14]
Molecule Alteration	Missense mutation		p.L74M+p.T97A+p.S119P	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included L74M, T97A, S119P.
Key Molecule: HIV1 Integrase (HIV1 IT)				[13]
Molecule Alteration	Missense mutation		p.S24G+p.N155H+p.D253E	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S24G, N155H, D253E.
Key Molecule: HIV1 Integrase (HIV1 IT)				[14]
Molecule Alteration	Missense mutation		p.L74M+p.T97A+p.S119R	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included L74M, T97A, S119R.
Key Molecule: HIV1 Integrase (HIV1 IT)				[15]
Molecule Alteration	Missense mutation		p.V151L	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included V151L.
Key Molecule: HIV1 Integrase (HIV1 IT)				[13]
Molecule Alteration	Missense mutation		p.L45Q+p.T115H	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included L45Q, T115H.
Key Molecule: HIV1 Integrase (HIV1 IT)				[13]
Molecule Alteration	Missense mutation		p.E92Q	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E92Q.
Key Molecule: HIV1 Integrase (HIV1 IT)				[14]
Molecule Alteration	Missense mutation		p.L74M+p.T97A+p.S119R	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included L74M, T97A, S119R.
Key Molecule: HIV1 Integrase (HIV1 IT)				[15]
Molecule Alteration	Missense mutation		p.E92Q	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E92Q.
Key Molecule: HIV1 Integrase (HIV1 IT)				[15]
Molecule Alteration	Missense mutation		p.P145S	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included P145S.
Key Molecule: HIV1 Integrase (HIV1 IT)				[13]
Molecule Alteration	Missense mutation		p.N155H	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included N155H.
Key Molecule: HIV1 Integrase (HIV1 IT)				[13]
Molecule Alteration	Missense mutation		p.T66I+p.S153F	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included T66I, S153F.
Key Molecule: HIV1 Integrase (HIV1 IT)				[15]
Molecule Alteration	Missense mutation		p.N155H	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included N155H.
Key Molecule: HIV1 Integrase (HIV1 IT)				[16]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.E92Q+p.S123G+p.T124A+p.K127R+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E10D, I72V, E92Q, S123G, T124A, K127R, D232N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[16]
Molecule Alteration	Missense mutation		p.E10D+p.T66I+p.I72V+p.F121Y+p.S123G+p.T124A+p.K127R+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E10D, T66I, I72V, F121Y, S123G, T124A, K127R, D232N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[13]
Molecule Alteration	Missense mutation		p.I72A+p.N155H	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72A, N155H.
Key Molecule: HIV1 Integrase (HIV1 IT)				[16]
Molecule Alteration	Missense mutation		p.E10D+p.T66I+p.I72V+p.S123G+p.T124A+p.K127R+p.S153Y+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E10D, T66I, I72V, S123G, T124A, K127R, S153Y, D232N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[15]
Molecule Alteration	Missense mutation		p.T66K	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included T66K.
Key Molecule: HIV1 Integrase (HIV1 IT)				[13]
Molecule Alteration	Missense mutation		p.E92Q+p.G140A	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E92Q, G140A.
Key Molecule: HIV1 Integrase (HIV1 IT)				[13]
Molecule Alteration	Missense mutation		p.Q148K	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included Q148K.
Key Molecule: HIV1 Integrase (HIV1 IT)				[14]
Molecule Alteration	Missense mutation		p.S119R+p.F121Y	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S119R, F121Y.
Key Molecule: HIV1 Integrase (HIV1 IT)				[16]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.E92Q+p.S123G+p.T124A+p.K127R+p.S147G+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E10D, I72V, E92Q, S123G, T124A, K127R, S147G, D232N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[13]
Molecule Alteration	Missense mutation		p.Q148R	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included Q148R.
Key Molecule: HIV1 Integrase (HIV1 IT)				[13]
Molecule Alteration	Missense mutation		p.T66I+p.R263K	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included T66I, R263K.
Key Molecule: HIV1 Integrase (HIV1 IT)				[15]
Molecule Alteration	Missense mutation		p.Q148R	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included Q148R.
Key Molecule: HIV1 Integrase (HIV1 IT)				[16]
Molecule Alteration	Missense mutation		p.E10D+p.T66I+p.I72V+p.S123G+p.T124A+p.K127R+p.D232N+p.R263K	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E10D, T66I, I72V, S123G, T124A, K127R, D232N, R263K.
Key Molecule: HIV1 Integrase (HIV1 IT)				[15]
Molecule Alteration	Missense mutation		p.Q148K	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included Q148K.
Key Molecule: HIV1 Integrase (HIV1 IT)				[13]
Molecule Alteration	Missense mutation		p.Q148R+p.N155H	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included Q148R, N155H.
Key Molecule: HIV1 Integrase (HIV1 IT)				[13]
Molecule Alteration	Missense mutation		p.E138K+p.Q148R	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E138K, Q148R.
Key Molecule: HIV1 Integrase (HIV1 IT)				[13]
Molecule Alteration	Missense mutation		p.E138K+p.G140A+p.Q148R	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E138K, G140A, Q148R.
Key Molecule: HIV1 Integrase (HIV1 IT)				[13]
Molecule Alteration	Missense mutation		p.G140A+p.Q148R	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included G140A, Q148R.
Key Molecule: HIV1 Integrase (HIV1 IT)				[13]
Molecule Alteration	Missense mutation		p.T66I+p.E138K+p.Q148R	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included T66I, E138K, Q148R.
Key Molecule: HIV1 Integrase (HIV1 IT)				[13]
Molecule Alteration	Missense mutation		p.T66I+p.E138K+p.Q148K	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included T66I, E138K, Q148K.
Key Molecule: HIV1 Integrase (HIV1 IT)				[13]
Molecule Alteration	Missense mutation		p.E138K+p.Q148K	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E138K, Q148K.
Key Molecule: HIV1 Integrase (HIV1 IT)				[13]
Molecule Alteration	Missense mutation		p.T66I+p.Q148K	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included T66I, Q148K.
Key Molecule: HIV1 Integrase (HIV1 IT)				[15]
Molecule Alteration	Missense mutation		p.Q146I	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included Q146I.
Key Molecule: HIV1 Integrase (HIV1 IT)				[16]
Molecule Alteration	Missense mutation		p.E10D+p.H51Y+p.I72V+p.E92Q+p.S123G+p.T124A+p.K127R+p.S147G+p.E157Q+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E10D, H51Y, I72V, E92Q, S123G, T124A, K127R, S147G, E157Q, D232N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[16]
Molecule Alteration	Missense mutation		p.E10D+p.H51Y+p.I72V+p.E92Q+p.S123G+p.T124A+p.K127R+p.S147G+p.D232N	Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E10D, H51Y, I72V, E92Q, S123G, T124A, K127R, S147G, D232N.

Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
Aberration of the Drug's Therapeutic Target (ADTT)			Click to Show/Hide
Key Molecule: HIV1 Integrase (HIV1 IT)				[4]
Molecule Alteration	Missense mutation		p.I72V+p.I113V+p.G140S+p.Q148H+p.V151I+p.L234V	Molecule Info
Sensitive Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	PCR; DNA sequencing assay
Experiment for Drug Resistance	PhenoSense assay
Mechanism Description	Q148N, a novel integrase inhibitor resistance mutation associated with low-level reduction in elvitegravir susceptibility.
Key Molecule: HIV1 Integrase (HIV1 IT)				[3]
Molecule Alteration	Missense mutation		p.I72V+p.I113V+p.E138K+p.V151I+p.L234V	Molecule Info
Sensitive Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
In Vitro Model	BL21 cells	Cerebrospinal fluid	Homo sapiens (Human)	CVCL_M639
Experiment for Molecule Alteration	Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay
Mechanism Description	Amino acid changes in IN may contribute to elvitegravir resistance or sensitivity.
Key Molecule: HIV1 Integrase (HIV1 IT)				[3]
Molecule Alteration	Missense mutation		p.E11D+p.K14R+p.S24N+p.V31I+p.M50I+p.L74I+p.A91E+p.L101I+p.T112V+p.S119R+p.T124A+p.T125A+p.A133T+p.G134N+p.I135V+p.K136T+p.E138K+p.V165I+p.V201I+p.T206S+p.T218I+p.L234I+p.S283D	Molecule Info
Sensitive Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
In Vitro Model	BL21 cells	Cerebrospinal fluid	Homo sapiens (Human)	CVCL_M639
Experiment for Molecule Alteration	Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay
Mechanism Description	Amino acid changes in IN may contribute to elvitegravir resistance or sensitivity.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.S123G+p.T124A+p.K127R+p.E170A+p.D232N	Molecule Info
Sensitive Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E306Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.S123G+p.T124A+p.K127R+p.G163K+p.D232N	Molecule Info
Sensitive Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E303Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.S123G+p.T124A+p.K127R+p.E157Q+p.D232N	Molecule Info
Sensitive Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E314Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.S123G+p.T124A+p.K127R+p.E157K+p.D232N	Molecule Info
Sensitive Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E299Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.S123G+p.T124A+p.K127R+p.S153A+p.D232N	Molecule Info
Sensitive Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E316Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.S123G+p.T124A+p.K127R+p.Q146K+p.D232N	Molecule Info
Sensitive Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E318Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.S123G+p.T124A+p.K127R+p.E138K+p.D232N	Molecule Info
Sensitive Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E298Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.S123G+p.T124A+p.K127R+p.E138A+p.D232N	Molecule Info
Sensitive Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E297Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.S123G+p.T124A+p.K127R+p.A128T+p.D232N	Molecule Info
Sensitive Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E302Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.Q95R+p.S123G+p.T124A+p.K127R+p.D232N	Molecule Info
Sensitive Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E308Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.Q95K+p.S123G+p.T124A+p.K127R+p.D232N	Molecule Info
Sensitive Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E313Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.I72T+p.S123G+p.T124A+p.K127R+p.D232N	Molecule Info
Sensitive Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E319Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.L68V+p.I72V+p.S123G+p.T124A+p.K127R+p.D232N	Molecule Info
Sensitive Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E310Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.L68I+p.I72V+p.S123G+p.T124A+p.K127R+p.D232N	Molecule Info
Sensitive Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E312Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.S123G+p.T124A+p.K127R+p.Y143H+p.D232N	Molecule Info
Sensitive Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E305Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.S123G+p.T124A+p.K127R+p.Y143C+p.D232N	Molecule Info
Sensitive Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E317Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.G163R	Molecule Info
Sensitive Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E309Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.S119T	Molecule Info
Sensitive Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E304Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.S119R	Molecule Info
Sensitive Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E315Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.S119P	Molecule Info
Sensitive Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E311Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.S119G	Molecule Info
Sensitive Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E301Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.L74M	Molecule Info
Sensitive Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E307Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[1]
Molecule Alteration	Missense mutation		p.M50I	Molecule Info
Sensitive Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	IN sequencing assay
Experiment for Drug Resistance	SDMs and phenotyping assay
Mechanism Description	Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-na ve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E300Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.
Key Molecule: HIV1 Integrase (HIV1 IT)				[6]
Molecule Alteration	Missense mutation		p.S24SG+p.C56Y+p.S57N+p.K156N+p.K211R+p.L234I	Molecule Info
Sensitive Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S24SG, C56Y, S57N, K156N, K211R, L234I.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.K14KR+p.V31I+p.G106A+p.T112I+p.T124A+p.T125A+p.G134D+p.K136Q+p.D167E+p.V201I+p.D229X+p.L234I+p.S283SG	Molecule Info
Sensitive Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included K14KR, V31I, G106A, T112I, T124A, T125A, G134D, K136Q, D167E, V201I, D229X, L234I, S283SG.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.S17N+p.I84L+p.T112I+p.T124S+p.T125A+p.V201I+p.I203M+p.L234I+p.D256E+p.A265V	Molecule Info
Sensitive Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17N, I84L, T112I, T124S, T125A, V201I, I203M, L234I, D256E, A265V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.L101I+p.G106GA+p.T124A+p.K156N+p.V201I+p.I217V+p.P261S+p.R262L	Molecule Info
Sensitive Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included L101I, G106GA, T124A, K156N, V201I, I217V, P261S, R262L.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.E11D+p.D25E+p.V31I+p.L101LI+p.K111T+p.I113IV+p.S119X+p.T122TI+p.T124TA+p.V126VMI+p.V201I+p.S230N+p.A265V	Molecule Info
Sensitive Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, D25E, V31I, L101LI, K111T, I113IV, S119X, T122TI, T124TA, V126VMI, V201I, S230N, A265V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[6]
Molecule Alteration	Missense mutation		p.S17N+p.I84IV+p.E87ED+p.L101I+p.K156N+p.D256E	Molecule Info
Sensitive Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17N, I84IV, E87ED, L101I, K156N, D256E.
Key Molecule: HIV1 Integrase (HIV1 IT)				[6]
Molecule Alteration	Missense mutation		p.S17N+p.R20RK+p.V31I+p.T124A+p.E157Q+p.K160Q+p.V201I+p.K211R+p.L213S+p.N222K+p.S230SN+p.S255G+p.A265V+p.R284G	Molecule Info
Sensitive Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17N, R20RK, V31I, T124A, E157Q, K160Q, V201I, K211R, L213S, N222K, S230SN, S255G, A265V, R284G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[6]
Molecule Alteration	Missense mutation		p.M50MI+p.L101I+p.T112V+p.I220V+p.D253E	Molecule Info
Sensitive Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included M50MI, L101I, T112V, I220V, D253E.
Key Molecule: HIV1 Integrase (HIV1 IT)				[7]
Molecule Alteration	Missense mutation		p.S17N+p.L28I+p.S39SC+p.T124A+p.T125A+p.G163E+p.V201I+p.K240R	Molecule Info
Sensitive Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17N, L28I, S39SC, T124A, T125A, G163E, V201I, K240R.
Key Molecule: HIV1 Integrase (HIV1 IT)				[7]
Molecule Alteration	Missense mutation		p.E11D+p.H12HR+p.L74LIM+p.A86AV+p.T93TI+p.L101I+p.K111KT+p.I113IV+p.S119AG+p.T122TI+p.T124N+p.S195T+p.V201I+p.T206S+p.Y227F+p.L234I+p.S255N+p.D256E+p.S283G	Molecule Info
Sensitive Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, H12HR, L74LIM, A86AV, T93TI, L101I, K111KT, I113IV, S119AG, T122TI, T124N, S195T, V201I, T206S, Y227F, L234I, S255N, D256E, S283G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[7]
Molecule Alteration	Missense mutation		p.S39SC+p.L45LI+p.L101I+p.V201I+p.K219Q+p.D256E+p.D286DN	Molecule Info
Sensitive Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S39SC, L45LI, L101I, V201I, K219Q, D256E, D286DN.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.E10D+p.T93TA+p.T124TA+p.I135IV+p.V201I+p.E212EG+p.R284G	Molecule Info
Sensitive Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E10D, T93TA, T124TA, I135IV, V201I, E212EG, R284G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.K14R+p.S17N+p.V31VI+p.I60M+p.L101I+p.T112V+p.T124A+p.I135IV+p.E138D+p.K188KR+p.V201I+p.A265V+p.S283G+p.R284RG+p.D286N	Molecule Info
Sensitive Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included K14R, S17N, V31VI, I60M, L101I, T112V, T124A, I135IV, E138D, K188KR, V201I, A265V, S283G, R284RG, D286N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.V31I+p.L101I+p.T112I+p.T124A+p.T125V+p.I135V+p.G163QH+p.A179G+p.F181L+p.V201I+p.T206S+p.L234I+p.D256E+p.I268L+p.D270H	Molecule Info
Sensitive Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included V31I, L101I, T112I, T124A, T125V, I135V, G163QH, A179G, F181L, V201I, T206S, L234I, D256E, I268L, D270H.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.S17SN+p.S24SN+p.M50MI+p.T124TA+p.T125A+p.K156N+p.E157Q+p.K211Q+p.D256E+p.S283SG+p.R284G+p.D288N	Molecule Info
Sensitive Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17SN, S24SN, M50MI, T124TA, T125A, K156N, E157Q, K211Q, D256E, S283SG, R284G, D288N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.S17N+p.K34R+p.L74V+p.L101I+p.T124A+p.K173R+p.A265V	Molecule Info
Sensitive Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17N, K34R, L74V, L101I, T124A, K173R, A265V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.L101I+p.K111T+p.I135V+p.K173R+p.V176L+p.A205T+p.K211R+p.T218S+p.S230N+p.D256E+p.D270E	Molecule Info
Sensitive Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included L101I, K111T, I135V, K173R, V176L, A205T, K211R, T218S, S230N, D256E, D270E.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.V31I+p.M50MT+p.L101I+p.K111Q+p.P142PS+p.P261PS+p.A265V	Molecule Info
Sensitive Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included V31I, M50MT, L101I, K111Q, P142PS, P261PS, A265V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.E11D+p.L101I+p.T124A+p.K136KT+p.F181L+p.G193R+p.V201I+p.T206S+p.D253E+p.D256E+p.R284RG	Molecule Info
Sensitive Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11D, L101I, T124A, K136KT, F181L, G193R, V201I, T206S, D253E, D256E, R284RG.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.S17N+p.D25E+p.M50I+p.L101I+p.T124TA+p.K156N+p.I204IL+p.Q221S+p.N222K+p.D253E	Molecule Info
Sensitive Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included S17N, D25E, M50I, L101I, T124TA, K156N, I204IL, Q221S, N222K, D253E.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.K7R+p.D25E+p.H51HQ+p.F100Y+p.L101I+p.T112V+p.T124A+p.T125A+p.K136Q+p.V165I+p.V201I+p.T218I+p.K219Q+p.L234I+p.S255G+p.R269K+p.D278A+p.S283G	Molecule Info
Sensitive Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included K7R, D25E, H51HQ, F100Y, L101I, T112V, T124A, T125A, K136Q, V165I, V201I, T218I, K219Q, L234I, S255G, R269K, D278A, S283G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.K14R+p.D25E+p.K34R+p.M50MI+p.I72IV+p.F100Y+p.L101I+p.T112V+p.S119T+p.T124A+p.T125A+p.K136Q+p.V201I+p.T218I+p.L234I+p.D256DE+p.D278A+p.S283G	Molecule Info
Sensitive Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included K14R, D25E, K34R, M50MI, I72IV, F100Y, L101I, T112V, S119T, T124A, T125A, K136Q, V201I, T218I, L234I, D256DE, D278A, S283G.
Key Molecule: HIV1 Integrase (HIV1 IT)				[8]
Molecule Alteration	Missense mutation		p.E11ED+p.S17C+p.H67HP+p.S81SR+p.S119P+p.T124N+p.T125A+p.V126L+p.I182V+p.T206S	Molecule Info
Sensitive Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E11ED, S17C, H67HP, S81SR, S119P, T124N, T125A, V126L, I182V, T206S.
Key Molecule: HIV1 Integrase (HIV1 IT)				[11]
Molecule Alteration	Missense mutation		p.E10D+p.I72V+p.S123G+p.T124A+p.K127R+p.E138K+p.D232N	Molecule Info
Sensitive Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E10D, I72V, S123G, T124A, K127R, E138K, D232N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[11]
Molecule Alteration	Missense mutation		p.I72V+p.I113V+p.E138K+p.L234V	Molecule Info
Sensitive Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included I72V, I113V, E138K, L234V.
Key Molecule: HIV1 Integrase (HIV1 IT)				[11]
Molecule Alteration	Missense mutation		p.E10D+p.L68I+p.I72V+p.S123G+p.T124A+p.K127R+p.D232N	Molecule Info
Sensitive Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E10D, L68I, I72V, S123G, T124A, K127R, D232N.
Key Molecule: HIV1 Integrase (HIV1 IT)				[13]
Molecule Alteration	Missense mutation		p.E157K	Molecule Info
Sensitive Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E157K.
Key Molecule: HIV1 Integrase (HIV1 IT)				[13]
Molecule Alteration	Missense mutation		p.E138K	Molecule Info
Sensitive Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Sanger sequencing assay; GeneSeq assay; Population sequencing of the integrase region assay; DNA sequencing assay; Site-directed mutagenesis
Experiment for Drug Resistance	PhenoSense assay; Viral load assay; A single-cycle assay; TZM-bl cell line-based phenotypic assay; SDMs and phenotyping assay
Mechanism Description	Some mutations identified were assiacted with resistance in the HIV isolates, those mutations included E138K.

References

Ref 1	Antiviral activity of HIV-1 integrase strand-transfer inhibitors against mutants with integrase resistance-associated mutations and their frequency in treatment-na ve individuals. J Med Virol. 2019 Dec;91(12):2188-2194. doi: 10.1002/jmv.25564. Epub 2019 Aug 20.
Ref 2	Evolution of a novel pathway leading to dolutegravir resistance in a patient harbouring N155H and multiclass drug resistance. J Antimicrob Chemother. 2015 Feb;70(2):405-11. doi: 10.1093/jac/dku387. Epub 2014 Oct 3.
Ref 3	Differential effects of the G118R, H51Y, and E138K resistance substitutions in different subtypes of HIV integrase. J Virol. 2015 Mar;89(6):3163-75. doi: 10.1128/JVI.03353-14. Epub 2014 Dec 31.
Ref 4	Q148N, a Novel Integrase Inhibitor Resistance Mutation Associated with Low-Level Reduction in Elvitegravir Susceptibility. AIDS Res Hum Retroviruses. 2016 Jul;32(7):702-4. doi: 10.1089/AID.2016.0038. Epub 2016 Apr 19.
Ref 5	The R263K substitution in HIV-1 subtype C is more deleterious for integrase enzymatic function and viral replication than in subtype B. AIDS. 2015 Jul 31;29(12):1459-66. doi: 10.1097/QAD.0000000000000752.
Ref 6	Co-formulated elvitegravir, cobicistat, emtricitabine, and tenofovir versus co-formulated efavirenz, emtricitabine, and tenofovir for initial treatment of HIV-1 infection: a randomised, double-blind, phase 3 trial, analysis of results after 48 weeksLancet. 2012 Jun 30;379(9835):2439-2448. doi: 10.1016/S0140-6736(12)60917-9.
Ref 7	Co-formulated elvitegravir, cobicistat, emtricitabine, and tenofovir disoproxil fumarate versus ritonavir-boosted atazanavir plus co-formulated emtricitabine and tenofovir disoproxil fumarate for initial treatment of HIV-1 infection: a randomised, double-blind, phase 3, non-inferiority trialLancet. 2012 Jun 30;379(9835):2429-2438. doi: 10.1016/S0140-6736(12)60918-0.
Ref 8	Efficacy and safety of once daily elvitegravir versus twice daily raltegravir in treatment-experienced patients with HIV-1 receiving a ritonavir-boosted protease inhibitor: randomised, double-blind, phase 3, non-inferiority studyLancet Infect Dis. 2012 Jan;12(1):27-35. doi: 10.1016/S1473-3099(11)70249-3. Epub 2011 Oct 18.
Ref 9	Impact of primary elvitegravir resistance-associated mutations in HIV-1 integrase on drug susceptibility and viral replication fitnessAntimicrob Agents Chemother. 2013 Jun;57(6):2654-63. doi: 10.1128/AAC.02568-12. Epub 2013 Mar 25.
Ref 10	Multiple genetic pathways involving amino acid position 143 of HIV-1 integrase are preferentially associated with specific secondary amino acid substitutions and confer resistance to raltegravir and cross-resistance to elvitegravirAntimicrob Agents Chemother. 2013 Sep;57(9):4105-13. doi: 10.1128/AAC.00204-13. Epub 2013 Jun 3.
Ref 11	Strand transfer inhibitors of HIV-1 integrase: bringing IN a new era of antiretroviral therapyAntiviral Res. 2010 Jan;85(1):101-18. doi: 10.1016/j.antiviral.2009.11.004. Epub 2009 Nov 17.
Ref 12	Viral fitness cost prevents HIV-1 from evading dolutegravir drug pressureRetrovirology. 2013 Feb 22;10:22. doi: 10.1186/1742-4690-10-22.
Ref 13	Integrase Inhibitor Resistance Selections Initiated with Drug Resistant HIV-1.
Ref 14	Bictegravir Resistance Profile: Data for External Experts.
Ref 15	Pre-existing HIV-1 integrase polymorphisms do not impact treatment response to elvitegravir-containing fixed-dose combination regimens in treatment-naive patients.
Ref 16	Resistance profile of HIV-1 mutants in vitro selected by the HIV-1 integrase inhibitor, GS-9137 (JTK-303). .

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Prof. Feng ZHU (zhufeng@zju.edu.cn)