Emtricitabine (ID: DG00939) Resistance Data of HIV

Drug Resistance Data Categorized by Their Corresponding Mechanisms
Aberration of the Drug's Therapeutic Target (ADTT)			Click to Show/Hide
Key Molecule: Gag-Pol polyprotein (POL)				Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]
Molecule Alteration	Alteration Patterns Alteration Types Resistance Mutation Total Point Scores Levels of Drug resistance base on the total point score Ref p.M184V+p.M184I Missense mutation N.A. Resistance [1]
Resistant Drug	Emtricitabine			Drug Info
Experimental Note	Discovered Using In-vivo Testing Model
Mechanism Description	Certain amino acid substitutions in the reverse transcriptase of HIV-1 can also reduce susceptibility to emtricitabine (M184V/I) and tenofovir AF (K65R, sometimes plus S68N or L429I; and transiently K70E), although selection of high-level resistance has not occurred with the latter drug over extended periods of culture in vitro.

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