Disease Information

General Information of the Disease (ID: DIS00560)

• Name: Toxoplasmosis
• ICD: ICD-11: 1F57

Type(s) of Resistant Mechanism of This Disease

  ADTT: Aberration of the Drug's Therapeutic Target

Drug Resistance Data Categorized by Drug

Clinical Trial Drug(s) 1 drug(s) in total

Altiratinib

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Aberration of the Drug's Therapeutic Target (ADTT)

Key Molecule: Pre-mRNA processing factor 4 kinase (PRP4K) [1]

• Resistant Disease: Toxoplasmosis [ICD-11: 1F57.Z]
• Resistant Drug: Altiratinib
• Molecule Alteration: Mutation; F647S
• Experiment for Molecule Alteration: DNA sequencing assay
• Experiment for Drug Resistance: Fluorescence microscopy assay
• Mechanism Description: Mutant strains edited for?TgPRP4K significantly decreased sensitivity to altiratinib

Key Molecule: Pre-mRNA processing factor 4 kinase (PRP4K) [1]

• Resistant Disease: Toxoplasmosis [ICD-11: 1F57.Z]
• Resistant Drug: Altiratinib
• Molecule Alteration: Mutation; L686F
• Experiment for Molecule Alteration: DNA sequencing assay
• Experiment for Drug Resistance: Fluorescence microscopy assay
• Mechanism Description: Mutant strains edited for?TgPRP4K significantly decreased sensitivity to altiratinib

Key Molecule: Pre-mRNA processing factor 4 kinase (PRP4K) [1]

• Resistant Disease: Toxoplasmosis [ICD-11: 1F57.Z]
• Resistant Drug: Altiratinib
• Molecule Alteration: Mutation; F647S
• Experiment for Molecule Alteration: DNA sequencing assay
• Experiment for Drug Resistance: Plaque assay
• Mechanism Description: Mutant strains edited for?TgPRP4K significantly decreased sensitivity to altiratinib

Key Molecule: Pre-mRNA processing factor 4 kinase (PRP4K) [1]

• Resistant Disease: Toxoplasmosis [ICD-11: 1F57.Z]
• Resistant Drug: Altiratinib
• Molecule Alteration: Mutation; L393S, L393F, F397L, and F397I
• Experiment for Molecule Alteration: DNA sequencing assay
• Experiment for Drug Resistance: Plaque assay
• Mechanism Description: Mutant strains edited for?TgPRP4K significantly decreased sensitivity to altiratinib

Key Molecule: Pre-mRNA processing factor 4 kinase (PRP4K) [1]

• Resistant Disease: Toxoplasmosis [ICD-11: 1F57.Z]
• Resistant Drug: Altiratinib
• Molecule Alteration: Mutation; L715F
• Experiment for Molecule Alteration: DNA sequencing assay
• Experiment for Drug Resistance: Plaque assay
• Mechanism Description: Mutant strains edited for?TgPRP4K significantly decreased sensitivity to altiratinib

References

• Ref 1: Altiratinib blocks Toxoplasma gondii and Plasmodium falciparum development by selectively targeting a spliceosome kinase. Sci Transl Med. 2022 Aug 3;14(656):eabn3231.