Disease Information

General Information of the Disease (ID: DIS00557)

• Name: Brucellosis
• ICD: ICD-11: 1B95

Type(s) of Resistant Mechanism of This Disease

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Rifampin

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Key Molecule: Serine/threonine-protein kinase (STPK) [1]

• Resistant Disease: brucellosis [ICD-11: 1B95]
• Resistant Drug: Rifampin
• Molecule Alteration: Deletion mutation; .
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: STPK gene deletion cells; N.A.; Homo sapiens (Human); N.A.
• Experiment for Drug Resistance: MIC assay; MBC assay; RpoB?gene testing
• Mechanism Description: All these findings indicate that the absence of the STPK could increase sulfur metabolism and GSH levels, and decrease the NADPH oxidase activity and NADP+/NADPH ratio, which promotes the antioxidant capacity of B. melitensis.

References

• Ref 1: Serine/threonine protein kinase mediates rifampicin resistance in Brucella melitensis through interacting with ribosomal protein RpsD and affecting antioxidant capacity. mSystems. 2025 Jan 21;10(1):e0110924.