Disease Information

General Information of the Disease (ID: DIS00555)

• Name: Syphilis
• ICD: ICD-11: 1A6Z

Type(s) of Resistant Mechanism of This Disease

  ADTT: Aberration of the Drug's Therapeutic Target

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Zithromax

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Aberration of the Drug's Therapeutic Target (ADTT)

Key Molecule: 23s rRNA [1]

• Resistant Disease: syphilis [ICD-11: 1A60.Z]
• Resistant Drug: Zithromax
• Molecule Alteration: Mutation; A1518/1519
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: SS14 cells; N.A.; Homo sapiens (Human); N.A.
• Experiment for Drug Resistance: Susceptibility and recovery assay
• Mechanism Description: The experiments carried out to evaluate?T pallidum?resistance to macrolides showed that azithromycin was effective against?T pallidum?strains that did not have either of the 23S rRNA gene mutations (A2058G or A2059G) conferring resistance to macrolides, remained ineffective for two strains (SS14 and UW330B) carrying either one of the aforementioned mutations.

Key Molecule: 23s rRNA [2]

• Resistant Disease: syphilis [ICD-11: 1A60.Z]
• Resistant Drug: Zithromax
• Molecule Alteration: Mutation; A1518/1519
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: UW330B cells; N.A.; Homo sapiens (Human); N.A.
• Experiment for Drug Resistance: Susceptibility and recovery assay
• Mechanism Description: The experiments carried out to evaluate?T pallidum?resistance to macrolides showed that azithromycin was effective against?T pallidum?strains that did not have either of the 23S rRNA gene mutations (A2058G or A2059G) conferring resistance to macrolides, remained ineffective for two strains (SS14 and UW330B) carrying either one of the aforementioned mutations.

References

• Ref 1: Pancreatic neuroendocrine tumor progression and resistance to everolimus: the crucial role of NF-kB and STAT3 interplay. J Endocrinol Invest. 2024 May;47(5):1101-1117.
• Ref 2: Antimicrobial susceptibility of Treponema pallidum subspecies pallidum: an in-vitro study. Lancet Microbe. 2023 Dec;4(12):e994-e1004.