Disease Information

General Information of the Disease (ID: DIS00529)
Name
Tongue cancer
ICD
ICD-11: 2B62
Resistance Map
Type(s) of Resistant Mechanism of This Disease
  MRAP: Metabolic Reprogramming via Altered Pathways
Drug Resistance Data Categorized by Drug
Approved Drug(s)
2 drug(s) in total
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Capsaicin
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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
  Metabolic Reprogramming via Altered Pathways (MRAP) Click to Show/Hide
Key Molecule: AMP-activated kinase alpha-2 (PRKAA2) [1]
Metabolic Type Glucose metabolism
Sensitive Disease Tongue squamous cell carcinoma [ICD-11: 2B62.0]
Sensitive Drug Capsaicin
 Drug Info 
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Experimental Note Revealed Based on the Cell Line Data
Cell Pathway Regulation mTOR signaling pathway Activation hsa04150
AMPK signaling pathway Activation hsa04152
Insulin signaling pathway Activation hsa04910
In Vivo Model Tumor xenograft model Mice
Experiment for
Drug Resistance		 Tumor weight assay
Mechanism Description Overall, combined treatment with capsaicin and cisplatin reversed cisplatin resistance by inhibiting the Warburg effect and facilitating mitochondrial-dependent apoptosis via the AMPK/AKT/mTOR axis.
Key Molecule: AMP-activated kinase alpha-2 (PRKAA2) [1]
Metabolic Type Glucose metabolism
Sensitive Disease Tongue squamous cell carcinoma [ICD-11: 2B62.0]
Sensitive Drug Capsaicin
 Drug Info 
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Experimental Note Revealed Based on the Cell Line Data
Cell Pathway Regulation mTOR signaling pathway Activation hsa04150
AMPK signaling pathway Activation hsa04152
Insulin signaling pathway Activation hsa04910
In Vitro Model CAL27 cells Oral Homo sapiens (Human) CVCL_1107
Experiment for
Drug Resistance		 Cell viability assay
Mechanism Description Overall, combined treatment with capsaicin and cisplatin reversed cisplatin resistance by inhibiting the Warburg effect and facilitating mitochondrial-dependent apoptosis via the AMPK/AKT/mTOR axis.
Cisplatin
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
  Metabolic Reprogramming via Altered Pathways (MRAP) Click to Show/Hide
Key Molecule: AMP-activated kinase alpha-2 (PRKAA2) [1]
Metabolic Type Glucose metabolism
Resistant Disease Tongue squamous cell carcinoma [ICD-11: 2B62.0]
Resistant Drug Cisplatin
 Drug Info 
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Experimental Note Revealed Based on the Cell Line Data
Cell Pathway Regulation mTOR signaling pathway Activation hsa04150
AMPK signaling pathway Activation hsa04152
Insulin signaling pathway Activation hsa04910
In Vivo Model Tumor xenograft model Mice
Experiment for
Drug Resistance		 Tumor weight assay
Mechanism Description Overall, combined treatment with capsaicin and cisplatin reversed cisplatin resistance by inhibiting the Warburg effect and facilitating mitochondrial-dependent apoptosis via the AMPK/AKT/mTOR axis.
Key Molecule: AMP-activated kinase alpha-2 (PRKAA2) [1]
Metabolic Type Glucose metabolism
Resistant Disease Tongue squamous cell carcinoma [ICD-11: 2B62.0]
Resistant Drug Cisplatin
 Drug Info 
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Experimental Note Revealed Based on the Cell Line Data
Cell Pathway Regulation mTOR signaling pathway Activation hsa04150
AMPK signaling pathway Activation hsa04152
Insulin signaling pathway Activation hsa04910
In Vitro Model CAL27 cells Oral Homo sapiens (Human) CVCL_1107
Experiment for
Drug Resistance		 Cell viability assay
Mechanism Description Overall, combined treatment with capsaicin and cisplatin reversed cisplatin resistance by inhibiting the Warburg effect and facilitating mitochondrial-dependent apoptosis via the AMPK/AKT/mTOR axis.
References
Ref 1 Capsaicin reverses cisplatin resistance in tongue squamous cell carcinoma by inhibiting the Warburg effect and facilitating mitochondrial-dependent apoptosis via the AMPK/AKT/mTOR axis. Cell Biol Int. 2024 Aug;48(8):1097-1110.

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