Disease Information

General Information of the Disease (ID: DIS00526)

• Name: Colorectal cancer
• ICD: ICD-11: 2B91

Type(s) of Resistant Mechanism of This Disease

  MRAP: Metabolic Reprogramming via Altered Pathways

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Cetuximab

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Metabolic Reprogramming via Altered Pathways (MRAP)

Key Molecule: Tumor necrosis factor receptor-associated protein 1 (TRAP1) [1]

• Metabolic Type: Glucose metabolism
• Resistant Disease: Colorectal carcinomas [ICD-11: 2B91.Y]
• Resistant Drug: Cetuximab
• Molecule Alteration: Expression; Up-regulation
• Experimental Note: Identified from the Human Clinical Data
• In Vivo Model: Human RAS-wild-type mCRCs; Homo Sapiens
• Experiment for Molecule Alteration: Western blot analysis
• Experiment for Drug Resistance: 18F-FDG uptake
• Mechanism Description: TRAP1 is a determinant of metabolic rewiring in human CRCs by the modulation of PFK1 activity/stability and favors resistance to EGFR inhibitors through the regulation of glycolytic metabolism.

Key Molecule: Tumor necrosis factor receptor-associated protein 1 (TRAP1) [1]

• Metabolic Type: Glucose metabolism
• Resistant Disease: Colorectal carcinomas [ICD-11: 2B91.Y]
• Resistant Drug: Cetuximab
• Molecule Alteration: Expression; Up-regulation
• Experimental Note: Identified from the Human Clinical Data
• In Vivo Model: Human RAS-wild-type mCRCs; Homo Sapiens
• Experiment for Molecule Alteration: Western blot analysis
• Experiment for Drug Resistance: Stable tumors assay
• Mechanism Description: TRAP1 is a determinant of metabolic rewiring in human CRCs by the modulation of PFK1 activity/stability and favors resistance to EGFR inhibitors through the regulation of glycolytic metabolism.

Key Molecule: Tumor necrosis factor receptor-associated protein 1 (TRAP1) [1]

• Metabolic Type: Glucose metabolism
• Resistant Disease: Colorectal carcinomas [ICD-11: 2B91.Y]
• Resistant Drug: Cetuximab
• Molecule Alteration: Expression; Up-regulation
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: RAS-wild-type Caco2 cells; Colon; Homo sapiens (Human); CVCL_0025
• In Vitro Model: RAS-wild-type NCIH508 cells; Colon; Homo sapiens (Human); CVCL_1564
• Experiment for Molecule Alteration: Western blot analysis
• Mechanism Description: TRAP1 is a determinant of metabolic rewiring in human CRCs by the modulation of PFK1 activity/stability and favors resistance to EGFR inhibitors through the regulation of glycolytic metabolism.

References

• Ref 1: TRAP1 enhances Warburg metabolism through modulation of PFK1 expression/activity and favors resistance to EGFR inhibitors in human colorectal carcinomas. Mol Oncol. 2020 Dec;14(12):3030-3047.