Disease Information

General Information of the Disease (ID: DIS00421)

• Name: Central nervous system infection
• ICD: ICD-11: 1C8Y

Type(s) of Resistant Mechanism of This Disease

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Investigative Drug(s) 1 drug(s) in total

Lipopolysaccharide

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Key Molecule: prostaglandin-endoperoxide synthase 2, opposite strand 2 (Ptgs2os2) [1]

• Resistant Disease: Central nervous system infection [ICD-11: 1C8Y.0]
• Molecule Alteration: Down-regulation; Expression
• Resistant Drug: Lipopolysaccharide
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: Mouse primary microglia cells; N.A.; Homo sapiens (Human); CVCL_1110
• In Vitro Model: BV-2 cells; Brain; Mus musculus (Mouse); CVCL_0182
• In Vivo Model: C57BL/6N mouse model; Mus musculus
• Experiment for Molecule Alteration: Knockdown assay
• Experiment for Drug Resistance: CCK8 assay
• Mechanism Description: Intranasal delivery of EV-loaded small RNA could be developed as therapeutics for treatment of a multitude of CNS disorders.

References

• Ref 1: Intranasal Delivery of lincRNA-Cox2 siRNA Loaded Extracellular Vesicles Decreases Lipopolysaccharide-Induced Microglial Proliferation in MiceJ Neuroimmune Pharmacol. 2020 Sep;15(3):390-399. doi: 10.1007/s11481-019-09864-z. Epub 2019 Jul 20.