Disease Information

General Information of the Disease (ID: DIS00420)

• Name: Cardiovascular injury
• ICD: ICD-11: BE2Z

Type(s) of Resistant Mechanism of This Disease

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Investigative Drug(s) 1 drug(s) in total

Homocysteine

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Key Molecule: Growth arrest specific 5 (GAS5) [1]

• Resistant Disease: Cardiac microvascular endothelial cells injury [ICD-11: BE2Z.Y]
• Molecule Alteration: Down-regulation; Interaction
• Resistant Drug: Homocysteine
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: ECs; N.A.; Drosophila melanogaster (Fruit fly); CVCL_Z893
• In Vitro Model: CMECs; N.A.; .; N.A.
• Experiment for Molecule Alteration: Overexpression assay
• Experiment for Drug Resistance: MTT assay; EdU assay; TUNEL staining assay; Caspase-3 activity detection; Dual luciferase reporter gene assay
• Mechanism Description: Long-chain noncoding RNA GAS5 mediates oxidative stress in cardiac microvascular endothelial cells injury.

References

• Ref 1: lncRNA GAS5 restrains CCl(4)-induced hepatic fibrosis by targeting miR-23a through the PTEN/PI3K/Akt signaling pathwayAm J Physiol Gastrointest Liver Physiol. 2019 Apr 1;316(4):G539-G550. doi: 10.1152/ajpgi.00249.2018. Epub 2019 Feb 8.