Disease Information

General Information of the Disease (ID: DIS00418)

• Name: Radiculopathy
• ICD: ICD-11: 8B93

Type(s) of Resistant Mechanism of This Disease

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Ketamine

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Key Molecule: BLACAT1 overlapping LEMD1 locus (BLACAT1) [1]

• Resistant Disease: Anesthesia-induced neural cytotoxicity [ICD-11: 8B93.Y]
• Resistant Drug: Ketamine
• Molecule Alteration: Up-regulation; Expression
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: hiPSCs; N.A.; Homo sapiens (Human); N.A.
• Experiment for Molecule Alteration: qRT-PCR
• Experiment for Drug Resistance: Click-iT TUNEL alexaFluor-594 Imaging assay; Total Reactive Oxygen Species Assay; Caspase-Glo 3/7 assay
• Mechanism Description: Inhibition of long noncoding RNA BLACAT1 protects anesthesia-induced neural cytotoxicity in human induced pluripotent stem cells derived neurons.

References

• Ref 1: Inhibition of long noncoding RNA BLACAT1 protects anesthesia-induced neural cytotoxicity in human induced pluripotent stem cells derived neuronsEur J Pharmacol. 2019 Dec 15;865:172737. doi: 10.1016/j.ejphar.2019.172737. Epub 2019 Oct 14.