Disease Information

General Information of the Disease (ID: DIS00417)

• Name: Alcoholic liver disease
• ICD: ICD-11: DB94

Type(s) of Resistant Mechanism of This Disease

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Ethanol

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Key Molecule: X inactive specific transcript (XIST) [1]

• Resistant Disease: Liver fibrogenesis [ICD-11: DB94.Y]
• Resistant Drug: Ethanol
• Molecule Alteration: Up-regulation; Interaction
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: HSCs; N.A.; N.A.; N.A.
• In Vivo Model: Male C57BL/6 mice model; Mus musculus
• Experiment for Molecule Alteration: Mimic assay; Luciferase assay; qRT-PCR; Western bloting analysis
• Experiment for Drug Resistance: MTT assay; Dual luciferase reporter assay
• Mechanism Description: XIST enhances ethanol-induced HSCs autophagy and activation via miR-29b/HMGB1 axis.

References

• Ref 1: Long noncoding RNA XIST enhances ethanol-induced hepatic stellate cells autophagy and activation via miR-29b/HMGB1 axisIUBMB Life. 2019 Dec;71(12):1962-1972. doi: 10.1002/iub.2140. Epub 2019 Aug 16.