Disease Information

General Information of the Disease (ID: DIS00415)

• Name: Lung damage
• ICD: ICD-11: RA00

Type(s) of Resistant Mechanism of This Disease

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Investigative Drug(s) 1 drug(s) in total

Oxygen

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Key Molecule: Maternally expressed 3 (MEG3) [1]

• Resistant Disease: Lung damage [ICD-11: RA00]
• Molecule Alteration: Down-regulation; Interaction
• Resistant Drug: Oxygen
• Experimental Note: Discovered Using In-vivo Testing Model
• In Vitro Model: MLE-12 cells; Lung; Mus musculus (Mouse); CVCL_3751
• In Vivo Model: MEG3 knockdown mice model; Mus musculus
• Experiment for Molecule Alteration: Knockdown assay; qRT-PCR; Western bloting analysis; Luciferase assay; ELISA assay
• Experiment for Drug Resistance: MTT assay; LDH assay; Flow cytometry assay; HE staining assay
• Mechanism Description: Knockdown of MEG3 inhibits pyroptosis to alleviate hyperoxia lung injury by suppressing NLRP3 inflammasome and caspase-1 signaling via regulating miR-18a-TXNIP axis.

References

• Ref 1: LncRNA MEG3 contributes to adenosine-induced cytotoxicity in hepatoma HepG2 cells by downregulated ILF3 and autophagy inhibition via regulation PI3K-AKT-mTOR and beclin-1 signaling pathwayJ Cell Biochem. 2019 Oct;120(10):18172-18185. doi: 10.1002/jcb.29123. Epub 2019 May 29.