Disease Information

General Information of the Disease (ID: DIS00414)

• Name: Neurotoxicity
• ICD: ICD-11: NE61

Type(s) of Resistant Mechanism of This Disease

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s) 2 drug(s) in total

Bupivacaine

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Key Molecule: Metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA) (Malat1) [1]

• Resistant Disease: Neurotoxicity [ICD-11: NE61.0]
• Molecule Alteration: Up-regulation; Interaction
• Resistant Drug: Bupivacaine
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: SH-SY5Y cells; Abdomen; Homo sapiens (Human); CVCL_0019
• Experiment for Molecule Alteration: Western bloting analysis; Dual luciferase assay; Knockdown assay
• Experiment for Drug Resistance: CCK8 assay; Caspase-3 activity assay
• Mechanism Description: Knockdown of LncRNA MALAT1 alleviates bupivacaine-induced neurotoxicity via the miR-101-3p/PDCD4 axis.

Hydrogen peroxide

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Key Molecule: Long non-protein coding RNA (LOC284930) [2]

• Resistant Disease: Neurotoxicity [ICD-11: NE61.0]
• Molecule Alteration: Down-regulation; Expression
• Resistant Drug: Hydrogen peroxide
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: SH-SY5Y cells; Abdomen; Homo sapiens (Human); CVCL_0019
• Experiment for Molecule Alteration: Overexpression assay; Knockdown assay
• Experiment for Drug Resistance: CCK8 assay; LDH assay; Caspase-3 activity assay
• Mechanism Description: Lnc-EPIC1 downregulation mediates H2O2-induced neuronal cell death.

References

• Ref 1: Knockdown of lncRNA MALAT1 alleviates bupivacaine-induced neurotoxicity via the miR-101-3p/PDCD4 axisLife Sci. 2019 Sep 1;232:116606. doi: 10.1016/j.lfs.2019.116606. Epub 2019 Jun 27.
• Ref 2: LncRNA EPIC1 downregulation mediates hydrogen peroxide-induced neuronal cell injuryAging (Albany NY). 2019 Dec 8;11(23):11463-11473. doi: 10.18632/aging.102545. Epub 2019 Dec 8.