Disease Information

General Information of the Disease (ID: DIS00411)

• Name: Periodontal ligament injury
• ICD: ICD-11: NA0D

Type(s) of Resistant Mechanism of This Disease

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Hydrogen peroxide

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Key Molecule: Long non-protein coding RNA (JHDM1D-AS1) [1]

• Resistant Disease: Periodontal ligament injury [ICD-11: NA0D.1]
• Molecule Alteration: Down-regulation; Expression
• Resistant Drug: Hydrogen peroxide
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: Periodontal ligament stem cells; N.A.; Homo sapiens (Human); N.A.
• Experiment for Molecule Alteration: Mimic assay; Overexpression assay
• Experiment for Drug Resistance: MTT assay; Cellular ROS detection assay; Flow cytometry assay
• Mechanism Description: Upregulation of JHDM1D-AS1 protects PDLSCs from H2O2-induced apoptosis by decreasing DNAJC10 via phosphorylation of eIF2alpha.

References

• Ref 1: Upregulation of JHDM1D-AS1 protects PDLSCs from H(2)O(2)-induced apoptosis by decreasing DNAJC10 via phosphorylation of eIF2AlphaBiochimie. 2019 Oct;165:48-56. doi: 10.1016/j.biochi.2019.06.018. Epub 2019 Jul 2.