Disease Information

General Information of the Disease (ID: DIS00408)

• Name: Neonatal pneumonia
• ICD: ICD-11: KB24

Type(s) of Resistant Mechanism of This Disease

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Investigative Drug(s) 1 drug(s) in total

Lipopolysaccharide

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Key Molecule: Long non-protein coding RNA (MIAT2) [1]

• Resistant Disease: Neonatal pneumonia [ICD-11: KB24.0]
• Molecule Alteration: Down-regulation; Interaction
• Resistant Drug: Lipopolysaccharide
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: WI-38 cells; Fetal lung; Homo sapiens (Human); CVCL_0579
• Experiment for Molecule Alteration: qRT-PCR; Western bloting analysis; Enzyme-linked immunosorbent assay; Mimic
• Experiment for Drug Resistance: CCK8 assay; Flow cytometry assay
• Mechanism Description: Long noncoding RNA MIAT2 alleviates lipopolysaccharide-induced inflammatory damage in WI-38 cells by sponging microRNA-15.

References

• Ref 1: Long noncoding RNA MIAT2 alleviates lipopolysaccharide-induced inflammatory damage in WI-38 cells by sponging microRNA-15J Cell Physiol. 2020 Apr;235(4):3690-3697. doi: 10.1002/jcp.29263. Epub 2019 Sep 30.