Disease Information

General Information of the Disease (ID: DIS00407)

• Name: Acute kidney failure
• ICD: ICD-11: GB60

Type(s) of Resistant Mechanism of This Disease

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Investigative Drug(s) 1 drug(s) in total

BTI-2571E

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Key Molecule: Colorectal neoplasia differentially expressed (CRNDE) [1]

• Resistant Disease: Sepsis-induced acute kidney injury [ICD-11: GB60.Z]
• Resistant Drug: BTI-2571E
• Molecule Alteration: Up-regulation; Expression
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: HK-2 cells; Kidney; Homo sapiens (Human); CVCL_0302
• Experiment for Molecule Alteration: Overexpression assay
• Experiment for Drug Resistance: Dual luciferase reporter assays; Flow cytometry assay
• Mechanism Description: CRNDE overexpression could activate the TLR4/NF-kappa-B signaling pathway by regulating miR-146a, which accelerated LPS-induced inflammation and apoptosis in HK-2 cells.

References

• Ref 1: Effects and Mechanism of lncRNA CRNDE on Sepsis-Induced Acute Kidney InjuryAnal Cell Pathol (Amst). 2020 May 1;2020:8576234. doi: 10.1155/2020/8576234. eCollection 2020.