Disease Information

General Information of the Disease (ID: DIS00399)

• Name: Myocardial ischemia
• ICD: ICD-11: BA6Z

Type(s) of Resistant Mechanism of This Disease

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Hydrogen peroxide

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Key Molecule: H19, imprinted maternally expressed transcript (H19) [1]

• Resistant Disease: Myocardial ischemia [ICD-11: BA6Z.0]
• Molecule Alteration: Up-regulation; Interaction
• Resistant Drug: Hydrogen peroxide
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: H9C2 cells; Ovary; Cricetulus griseus (Chinese hamster); CVCL_A0TS
• In Vivo Model: Rat model of heart IP and I/R injury; Rattus norvegicus
• Experiment for Molecule Alteration: Knockdown assay; Overexpression assay; qRT-PCR; Western bloting analysis; RIP experiments assay
• Experiment for Drug Resistance: CCK8 assay; caspase-3 activity assay
• Mechanism Description: LncRNA H19 is involved in myocardial IP via increasing the stability of nucleolin protein and LncRNA H19 may represent a potential therapeutic target for the treatment of the myocardial injury.

References

• Ref 1: Downregulation of lncRNA H19 sensitizes melanoma cells to cisplatin by regulating the miR-18b/IGF1 axisAnticancer Drugs. 2020 Jun;31(5):473-482. doi: 10.1097/CAD.0000000000000888.