Disease Information

General Information of the Disease (ID: DIS00388)

• Name: Systemic inflammatory response syndrome
• ICD: ICD-11: MG46

Type(s) of Resistant Mechanism of This Disease

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Investigative Drug(s) 1 drug(s) in total

Lipopolysaccharide

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Key Molecule: Functional intergenic repeating RNA element (Firre) [1]

• Resistant Disease: Systemic inflammatory response syndrome [ICD-11: MG46.0]
• Molecule Alteration: Up-regulation; Locus
• Resistant Drug: Lipopolysaccharide
• Experimental Note: Identified from the Human Clinical Data
• Experiment for Molecule Alteration: Overexpression assay
• Mechanism Description: The Firre locus produces a trans-acting RNA molecule that functions in hematopoiesis.

References

• Ref 1: The Firre locus produces a trans-acting RNA molecule that functions in hematopoiesisNat Commun. 2019 Nov 13;10(1):5137. doi: 10.1038/s41467-019-12970-4.