Disease Information

General Information of the Disease (ID: DIS00386)

• Name: Adrenal adenoma
• ICD: ICD-11: 2F3Z

Type(s) of Resistant Mechanism of This Disease

  UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Amiloride

Drug Sensitivity Data Categorized by Their Corresponding Mechanisms

Unusual Activation of Pro-survival Pathway (UAPP)

Key Molecule: G protein-activated inward rectifier potassium channel 4 (GIRK4) [1]

• Sensitive Disease: Adrenal adenoma [ICD-11: 2F3Z.0]
• Sensitive Drug: Amiloride
• Molecule Alteration: Missense mutation; p.L168R (c.503T>G)
• Experimental Note: Identified from the Human Clinical Data

References

• Ref 1: Pharmacology and pathophysiology of mutated KCNJ5 found in adrenal aldosterone-producing adenomasEndocrinology. 2014 Apr;155(4):1353-62. doi: 10.1210/en.2013-1944. Epub 2014 Feb 7.