Disease Information

General Information of the Disease (ID: DIS00331)

• Name: Ulcer
• ICD: ICD-11: EH90

Type(s) of Resistant Mechanism of This Disease

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Investigative Drug(s) 1 drug(s) in total

Lipopolysaccharide

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Key Molecule: ENSG00000247844 (CCAT1) [1]

• Resistant Disease: Pressure ulceration [ICD-11: EH90]
• Molecule Alteration: Up-regulation; Expression
• Resistant Drug: Lipopolysaccharide
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: HaCaT cells; Tongue; Homo sapiens (Human); CVCL_0038
• Experiment for Molecule Alteration: Overexpression assay; Knockdown assay; Western bloting analysis; ELISA assay; qRT-PCR
• Experiment for Drug Resistance: MTT assay; Flow cytometry assay
• Mechanism Description: The anti-inflammatory activity of sinomenine might be mediated by CCAT1 down-regulation.

References

• Ref 1: Sinomenine retards LPS-elicited inflammation via down-regulating CCAT1 in HaCaT cellsLife Sci. 2019 Sep 15;233:116703. doi: 10.1016/j.lfs.2019.116703. Epub 2019 Jul 26.