Disease Information

General Information of the Disease (ID: DIS00275)

• Name: Myasthenia gravis
• ICD: ICD-11: 8C60

Type(s) of Resistant Mechanism of This Disease

  IDUE: Irregularity in Drug Uptake and Drug Efflux

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Prednisone

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Irregularity in Drug Uptake and Drug Efflux (IDUE)

Key Molecule: Multidrug resistance protein 1 (ABCB1) [1]

• Resistant Disease: Myasthenia gravis [ICD-11: 8C60.0]
• Molecule Alteration: Expression; Up-regulation
• Resistant Drug: Prednisone
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Lymphocyte; Lymph node; Homo sapiens (Human); N.A.
• Experiment for Molecule Alteration: Flow cytometry assay
• Experiment for Drug Resistance: Flow cytometry assay
• Mechanism Description: Prednisone (PDN) is transported by P-glycoprotein (P-gp). P-gp overfunction has been associated with resistance to several drug.

Key Molecule: Multidrug resistance protein 1 (ABCB1) [1]

• Resistant Disease: Myasthenia gravis [ICD-11: 8C60.0]
• Molecule Alteration: Expression; Up-regulation
• Resistant Drug: Prednisone
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Lymphocyte; Lymph node; Homo sapiens (Human); N.A.
• Experiment for Molecule Alteration: Flow cytometry assay
• Experiment for Drug Resistance: Flow cytometry assay
• Mechanism Description: Prednisone (PDN) is transported by P-glycoprotein (P-gp). P-gp overfunction has been associated with resistance to several drug.

References

• Ref 1: Multidrug resistance-1 (MDR-1) in autoimmune disorders IV. P-glycoprotein overfunction in lymphocytes from myasthenia gravis patients .Biomed Pharmacother. 2004 Jun;58(5):320-4. doi: 10.1016/j.biopha.2004.04.008. 10.1016/j.biopha.2004.04.008