Disease Information

General Information of the Disease (ID: DIS00274)

• Name: Spinal cord injury
• ICD: ICD-11: 8C21

Type(s) of Resistant Mechanism of This Disease

  IDUE: Irregularity in Drug Uptake and Drug Efflux

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Riluzole

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Irregularity in Drug Uptake and Drug Efflux (IDUE)

Key Molecule: Multidrug resistance protein 1 (ABCB1) [1]

• Resistant Disease: Spinal cord injury [ICD-11: 8C21.0]
• Molecule Alteration: Expression; Up-regulation
• Resistant Drug: Riluzole
• Experimental Note: Identified from the Human Clinical Data
• In Vivo Model: Abcb1a Knockout rats model; Mus musculus
• Experiment for Molecule Alteration: Western blotting assay
• Experiment for Drug Resistance: High performance liquid chromatography assay
• Mechanism Description: Riluzole spinal cord disposition was significantly higher in knockout rats than in WT rats at 10 days post-spinal cord injury (p=0.019), confirming that Pgp plays a critical role in diminishing spinal cord riluzole disposition following spinal cord injury.

References

• Ref 1: The dual cyclooxygenase/5-lipoxygenase inhibitor licofelone attenuates p-glycoprotein-mediated drug resistance in the injured spinal cord .J Neurotrauma. 2013 Feb 1;30(3):211-26. doi: 10.1089/neu.2012.2587. Epub 2013 Jan 23. 10.1089/neu.2012.2587