Disease Information

General Information of the Disease (ID: DIS00264)

• Name: Status epilepticus
• ICD: ICD-11: 8A66

Type(s) of Resistant Mechanism of This Disease

  IDUE: Irregularity in Drug Uptake and Drug Efflux

Drug Resistance Data Categorized by Drug

Approved Drug(s) 2 drug(s) in total

Phenobarbital

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Irregularity in Drug Uptake and Drug Efflux (IDUE)

Key Molecule: Multidrug resistance protein 1 (ABCB1) [1]

• Resistant Disease: Status epilepticus [ICD-11: 8A66.0]
• Resistant Drug: Phenobarbital
• Molecule Alteration: Expression; Up-regulation
• Experimental Note: Identified from the Human Clinical Data
• Mechanism Description: Pgp is involved in the resistance to phenytoin and phenobarbital but not diazepam.

Phenytoin

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Irregularity in Drug Uptake and Drug Efflux (IDUE)

Key Molecule: Multidrug resistance protein 1 (ABCB1) [1]

• Resistant Disease: Status epilepticus [ICD-11: 8A66.0]
• Resistant Drug: Phenytoin
• Molecule Alteration: Expression; Up-regulation
• Experimental Note: Identified from the Human Clinical Data
• Mechanism Description: Pgp is involved in the resistance to phenytoin and phenobarbital but not diazepam.

References

• Ref 1: Mechanisms of drug resistance in status epilepticus .Epilepsia. 2007;48 Suppl 8:74-7. doi: 10.1111/j.1528-1167.2007.01357.x. 10.1111/j.1528-1167.2007.01357.x