Disease Information

General Information of the Disease (ID: DIS00208)

• Name: Peritoneal cancer
• ICD: ICD-11: 2C51

Type(s) of Resistant Mechanism of This Disease

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Preclinical Drug(s) 1 drug(s) in total

APR-246/Cisplatin

Drug Sensitivity Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Key Molecule: Cellular tumor antigen p53 (TP53) [1]

• Sensitive Disease: Peritoneal cancer [ICD-11: 2C51.0]
• Molecule Alteration: Missense mutation; p.C135Y (c.404G>A)
• Sensitive Drug: APR-246/Cisplatin
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Ascitic fluid; .
• Experiment for Molecule Alteration: Western blotting analysis
• Experiment for Drug Resistance: FMCA assay

References

• Ref 1: Strong synergy with APR-246 and DNA-damaging drugs in primary cancer cells from patients with TP53 mutant High-Grade Serous ovarian cancerJ Ovarian Res. 2016 May 14;9(1):27. doi: 10.1186/s13048-016-0239-6.