Disease Information

General Information of the Disease (ID: DIS00189)

• Name: Urinary tuberculosis
• ICD: ICD-11: 1G80

Type(s) of Resistant Mechanism of This Disease

  EADR: Epigenetic Alteration of DNA, RNA or Protein

  UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Drug

Approved Drug(s) 2 drug(s) in total

Isoniazid

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Unusual Activation of Pro-survival Pathway (UAPP)

Key Molecule: Catalase-peroxidase (KATG) [1]

• Resistant Disease: Urinary tuberculosis [ICD-11: 1G80.0]
• Resistant Drug: Isoniazid
• Molecule Alteration: Missense mutation; p.S531L
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Mycobacterium tuberculosis isolates; 1773
• Experiment for Molecule Alteration: Gene sequencing assay
• Mechanism Description: Regarding drug-resistance mutation profiles, the most prevalent mutation sites were katG S315T1 and rpoB S531L.

Key Molecule: DNA-directed RNA polymerase subunit beta (RPOB) [1]

• Resistant Disease: Urinary tuberculosis [ICD-11: 1G80.0]
• Resistant Drug: Isoniazid
• Molecule Alteration: Missense mutation; p.S531L
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Mycobacterium tuberculosis isolates; 1773
• Experiment for Molecule Alteration: Gene sequencing assay
• Mechanism Description: Regarding drug-resistance mutation profiles, the most prevalent mutation sites were katG S315T1 and rpoB S531L.

Key Molecule: Catalase-peroxidase (KATG) [1]

• Resistant Disease: Urinary tuberculosis [ICD-11: 1G80.0]
• Resistant Drug: Isoniazid
• Molecule Alteration: Missense mutation; p.S315T1
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Mycobacterium tuberculosis isolates; 1773
• Experiment for Molecule Alteration: Gene sequencing assay
• Mechanism Description: Regarding drug-resistance mutation profiles, the most prevalent mutation sites were katG S315T1 and rpoB S531L.

Key Molecule: DNA-directed RNA polymerase subunit beta (RPOB) [1]

• Resistant Disease: Urinary tuberculosis [ICD-11: 1G80.0]
• Resistant Drug: Isoniazid
• Molecule Alteration: Missense mutation; p.S315T1
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Mycobacterium tuberculosis isolates; 1773
• Experiment for Molecule Alteration: Gene sequencing assay
• Mechanism Description: Regarding drug-resistance mutation profiles, the most prevalent mutation sites were katG S315T1 and rpoB S531L.

Rifampin

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Key Molecule: DNA-directed RNA polymerase subunit beta (RPOB) [1]

• Resistant Disease: Urinary tuberculosis [ICD-11: 1G80.0]
• Resistant Drug: Rifampin
• Molecule Alteration: Missense mutation; p.S531L
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Mycobacterium tuberculosis isolates; 1773
• Experiment for Molecule Alteration: Gene sequencing assay
• Mechanism Description: Regarding drug-resistance mutation profiles, the most prevalent mutation sites were katG S315T1 and rpoB S531L.

Key Molecule: DNA-directed RNA polymerase subunit beta (RPOB) [1]

• Resistant Disease: Urinary tuberculosis [ICD-11: 1G80.0]
• Resistant Drug: Rifampin
• Molecule Alteration: Missense mutation; p.S315T1
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Mycobacterium tuberculosis isolates; 1773
• Experiment for Molecule Alteration: Gene sequencing assay
• Mechanism Description: Regarding drug-resistance mutation profiles, the most prevalent mutation sites were katG S315T1 and rpoB S531L.

Unusual Activation of Pro-survival Pathway (UAPP)

Key Molecule: Catalase-peroxidase (KATG) [1]

• Resistant Disease: Urinary tuberculosis [ICD-11: 1G80.0]
• Resistant Drug: Rifampin
• Molecule Alteration: Missense mutation; p.S531L
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Mycobacterium tuberculosis isolates; 1773
• Experiment for Molecule Alteration: Gene sequencing assay
• Mechanism Description: Regarding drug-resistance mutation profiles, the most prevalent mutation sites were katG S315T1 and rpoB S531L.

Key Molecule: Catalase-peroxidase (KATG) [1]

• Resistant Disease: Urinary tuberculosis [ICD-11: 1G80.0]
• Resistant Drug: Rifampin
• Molecule Alteration: Missense mutation; p.S315T1
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Mycobacterium tuberculosis isolates; 1773
• Experiment for Molecule Alteration: Gene sequencing assay
• Mechanism Description: Regarding drug-resistance mutation profiles, the most prevalent mutation sites were katG S315T1 and rpoB S531L.

References

• Ref 1: Clinical Features and Drug-Resistance Profile of Urinary Tuberculosis in South-Western China: A Cross-sectional Study .Medicine (Baltimore). 2016 May;95(19):e3537. doi: 10.1097/MD.0000000000003537. 10.1097/MD.0000000000003537