Disease Information

General Information of the Disease (ID: DIS00187)

• Name: Scabies
• ICD: ICD-11: 1G04

Type(s) of Resistant Mechanism of This Disease

  DISM: Drug Inactivation by Structure Modification

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Ivermectin

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Drug Inactivation by Structure Modification (DISM)

Key Molecule: Glutathione S-transferase kappa (GST) [1]

• Resistant Disease: Scabies [ICD-11: 1G04.0]
• Molecule Alteration: Expression; Up-regulation
• Resistant Drug: Ivermectin
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Sarcoptes scabiei isolates; 52283
• Mechanism Description: The enzyme GST catalyzes the formation of a thioester bond between reduced glutathione and drugs. This bond tags the drug for elimination from the body. Increased activity or expression of GST has been linked to resistance to both permethrin and ivermectin in different mite species.

References

• Ref 1: Scabies in the age of increasing drug resistance .PLoS Negl Trop Dis. 2017 Nov 30;11(11):e0005920. doi: 10.1371/journal.pntd.0005920. eCollection 2017 Nov. 10.1371/journal.pntd.0005920