Molecule Information

General Information of the Molecule (ID: Mol02232)

• Name: Long non-protein coding RNA (ACART) ,Mus musculus
• Synonyms: ACART
• Molecule Type: LncRNA
• Gene Name: ACART

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Hydrogen peroxide

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Ischemia/reperfusion injury [1]

• Resistant Disease: Ischemia/reperfusion injury [ICD-11: DB98.B]
• Resistant Drug: Hydrogen peroxide
• Molecule Alteration: Down-regulation; Expression
• Experimental Note: Discovered Using In-vivo Testing Model
• Cell Pathway Regulation: PPAR-gama/Bcl-2 signaling pathway; Activation; hsa04933
• In Vitro Model: NMVCs; N.A.; .; N.A.
• In Vivo Model: C57BL/6 mice and neonatal mice model of I/R injury model; Mus musculus
• Experiment for Molecule Alteration: Knockdown assay; Overexpression assay
• Experiment for Drug Resistance: MTT assay; TUNEL assay; Lactate dehydrogenase assay
• Mechanism Description: LncRNA ACART protects cardiomyocytes from apoptosis by activating PPAR- gama /Bcl-2 pathway.

References

• Ref 1: LncRNA ACART protects cardiomyocytes from apoptosis by activating PPAR-Gamma/Bcl-2 pathwayJ Cell Mol Med. 2020 Jan;24(1):737-746. doi: 10.1111/jcmm.14781. Epub 2019 Nov 20.