Molecule Information

General Information of the Molecule (ID: Mol02219)

• Name: Long non-protein coding RNA (CHRF) ,Homo sapiens
• Synonyms: CHRF
• Molecule Type: LncRNA
• Gene Name: CHRF

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Silicon dioxide

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Pulmonary fibrosis [1]

• Resistant Disease: Pulmonary fibrosis [ICD-11: CB03.1]
• Resistant Drug: Silicon dioxide
• Molecule Alteration: Up-regulation; Interaction
• Experimental Note: Discovered Using In-vivo Testing Model
• In Vitro Model: THP-1 cells; Blood; Homo sapiens (Human); CVCL_0006
• In Vitro Model: MRC-5 cells; Lung; Homo sapiens (Human); CVCL_0440
• In Vitro Model: RAW 264.7 cells; Ascites; Mus musculus (Mouse); CVCL_0493
• In Vitro Model: NIH/3T3 cells; Whole embryo; Mus musculus (Mouse); CVCL_0594
• In Vivo Model: Pulmonary fibrosis miR-489 overexpression mouse model; Mus musculus
• Experiment for Molecule Alteration: Overexpression assay
• Experiment for Drug Resistance: Immunofluorescence assay
• Mechanism Description: CHRF-miR-489-MyD88 Smad3 signaling axis exerts key functions in silica-induced pulmonary fibrosis and may represent a therapeutic target for silicosis.

References

• Ref 1: miR-489 inhibits silica-induced pulmonary fibrosis by targeting MyD88 and Smad3 and is negatively regulated by lncRNA CHRFSci Rep. 2016 Aug 10;6:30921. doi: 10.1038/srep30921.