Drug Information

Drug (ID: DG01795) and It's Reported Resistant Information

• Name: Silicon dioxide
• Synonyms: SILICON DIOXIDE; Silica; Quartz; Dioxosilane; 7631-86-9; Diatomaceous earth; Cristobalite; Silica gel; Tridymite; Sand; Infusorial earth; Silicic anhydride; KIESELGUHR; 112945-52-5; 14808-60-7; Aerosil; Crystalline silica; Diatomaceous silica; Dicalite; Wessalon; Glass; Ludox; Nyacol; Zorbax sil; 112926-00-8; 61790-53-2; Silica, amorphous; Cab-O-sil; Christensenite; Crystoballite; Silicon(IV) oxide; Siliceous earth; Synthetic amorphous silica; Amorphous silica; Silica, colloidal; 60676-86-0; QUARTZ (SIO2); 14464-46-1; Chalcedony; Diatomite; Agate; Cab-o-sil M-5; colloidal silica; Fused silica; Quartz glass; Quartz sand; Silica slurry; Silicone dioxide; SILICA, VITREOUS; Colloidal silicon dioxide; Siliceous earth, purified; Min-U-Sil; Silicon dioxide (amorphous); 15468-32-3; Silicon dioxide, fumed; Siliziumdioxid; 91053-39-3; UNII-ETJ7Z6XBU4; 68855-54-9; Kieselsaeureanhydrid; Silica Gel, 40-63 Micron Particles; CHEBI:30563; SiO2; (SiO2)n; 43-63C; ETJ7Z6XBU4; Silicon dioxide, colloidal; 15723-40-7; ENT 25,550; [SiO2]; Silica, crystalline - fused; Silicagel; Silicon dioxide, amorphous gel; 13778-37-5; 13778-38-6; 17679-64-0; Silicondioxide; Silica gel desiccant, indicating; Celite; Sand, Ottawa; Sand, Sea; silica gel desiccant; MFCD00011232; MFCD00217788; Silica, mesostructured; Sillikolloid; Acticel; Aerosil 380; Amethyst; Aquafil; Carplex; Cataloid; Crysvarl; Extrusil; Flintshot; Nalcoag; Novaculite; Porasil; Santocel; Silikil; Silikill; Siloxid; Sipernat; Superfloss; Vulkasil; Cherts; Neosil; Neosyl; Snowit; Aerosil-degussa; Imsil; Metacristobalite; Silica vitreous; Zipax; Quartz silica; alpha-Quartz; Fossil flour; Fumed silica; Quartz dust; Rock crystal; Rose quartz; Silica dust; White carbon; Chromosorb P; Silica particles; Tiger-eye; Vulkasil S; Celite superfloss; Cristobalite dust; Snowtex O; Corasil II; Silver bond B; Cab-O-sperse; alpha-Cristobalite; alpha-Crystobalite; Calcined diatomite; Tokusil TPLM; Dri-Die; Gold bond R; Cabosil st-1; Manosil vn 3; Sil-Co-Sil; Ultrasil VH 3; Ultrasil VN 3; Aerosil bs-50; Aerosil K 7; Cabosil N 5; Carplex 30; Carplex 80; Pigment White 27; Siderite (SiO2); Snowtex 30; Syton 2X; Tridymite 118; Zeofree 80; Cab-O-grip II; Silicon(IV) oxide, amorphous; Tridimite [French]; Amorphous silica gel; HI-Sil; Tridymite (SiO2); Glass wool, for laboratory use; Positive sol 232; Aerogel 200; Aerosil 300; Amorphous silica dust; Ludox hs 40; Silanox 101; Silica (SiO2); Vitasil 220; Positive sol 130M; Siliceous earth, purified (NF); Siliceous earth, purified [NF]; Silicon Oxide Hollow Nanospheres; Aerosil A 300; Aerosil E 300; Aerosil M-300; Cristobalite (SiO2); Nyacol 830; Sibelite M 3000; Sibelite M 4000; Sibelite M 6000; Quazo puro [Italian]; Caswell No. 734A; Nalfloc N 1050; Quso 51; Sicron F 300; Sikron F 100; Spectrosil; Accusand; Coesite; Fuselex; Nalcast; Nyacol 1430; Optocil; Quartzine; Quarzsand; Rancosil; Suprasil; Tridimite; Silica, amorphous fused; Siltex; Vitreous quartz; Vitreous silica; Tridymite dust; W 12 (Filler); beta-Quartz; Fused quartz; MIN-U-sil alpha quartz; Quartz-beta; Quso G 30; Silica glass; Amorphous quartz; Dri-Die insecticide 67; Nalco 1050; Quazo puro; Silica, amorphous, fumed; Vitrified silica; MFCD00163736; Pyrogenic colloidal silica; Silica gel, spherical, 60 angstroms; Hydrophobic silica 2482; Silica, fused; Suprasil W; Vitreosil IR; Borsil P; Calcined diatomaceous earth; Silica gel, spherical, 100 angstroms; Silica gel, spherical, 300 angstroms; Silane, dioxo-; Crystallized silicon dioxide; Optocil (quartz); CP-SilicaPLOT; Diatomaceous earth, calcined; Silicon oxide, di- (sand); Quarzsand [German]; S-Col; Admafine SO 25H; Admafine SO 25R; Admafine SO 32H; Admafine SO-C 2; Admafine SO-C 3; Cristobalite asbestos; Keatite (SiO2); Sg-67; Silica, amorphous, fumed, cryst.-free; Fumed silica, crystalline-free; Stishovite (SiO2); ED-C (silica); Fuselex ZA 30; As 1 (silica); CCRIS 2475; CCRIS 3699; DQ12; Agate (SiO2); Celite 545; Dimethyl siloxanes and silicones; Fumed synthetic amorphous silica; Silica, crystalline - tridymite; FB 5 (silica); Fuselex RD 120; Corning 7940; Microcrystalline quartz; Synthetic amorphous silica, fumed; Denka F 90; Denka FB 30; Denka FB 44; Denka FB 74; Denka FS 30; Dri-Die 67; Silica gel spherical, 40-75 mum particle size; WGL 300; Cryptocrystalline quartz; FB 20 (silica); Elsil 100; F 44 (filler); D & D; SF 35; Elsil BF 100; F 125 (silica); F 160 (silica); Fuselex RD 40-60; Silica, amorphous, fused; Silicon dioxide, chemically prepared; EINECS 231-545-4; EINECS 238-455-4; EINECS 238-878-4; EINECS 239-487-1; HK 400; TGL 16319; Silica gel 60, 0.060-0.2mm (70-230 mesh); Silica, crystalline quartz; Silicon dioxide (vitreous); EPA Pesticide Chemical Code 072605; Silica 2482, hydrophobic; CI 7811; Silica, crystalline, quartz; Silica, crystalline: quartz; GP 7I; CAB-O-SIL N-70TS; Silica, crystalline tridymite; Kieselgel; Seesand; Silica, crystalline - quartz; AF-SO 25R; Quartz [Silica, crystalline]; Siilca; Zorbax; quartz-glass; Silicom dioxide; Silica flour (powdered crystalline silica); Silica, crystalline: tridymite; silica-gel; Fused-silica; Silica,fumed; AI3-25549; GP 11I; RD 8; silica-; Silica, fumed; U 333; W 006; Silicon di-oxide; Tridymite [Silica, crystalline]; CRS 1102RD8; Silica Dispersion; SiO2 Nanopowder; Silica gel G; Silica, crystalline: cristobalite; Silica, tridymite; SiO2 Nanospheres; Diatomaceous earth, flux-calcined, filter aid, treated with sodium carbonate, flux calcined; Silica gel 60 ADAMANT(TM) on TLC plates, with fluorescent indicator 254 nm; EF 10; FS 74; MR 84; Silica, crystalline - cristobalite; Silica Microspheres; Cristobalite [Silica, crystalline]; Amorphous silica: Pyrogenic (fumed); EINECS 262-373-8; Silica gel, ASTM; Silica Nanoparticles; Methyl3-oxohexanoate; Siliceous sand, CP; BF 100; EQ 912; QG 100; RD 120; Celite 503; Nettles p.e. extract; Silicon Dioxide Powder; Sea sand, acid washed; Silica, fumed, powder; Silicon dioxide (NF); Activated Silica Powder; Activated Silicon Oxide; Sand 50-70 mesh; F 44; Silica gel, large pore; Y 40; SiO2.xH2O; Hollow Silica Nanosphere; Silicon Oxide Dispersion; Silicon Oxide Nanopowder; Activated Silicon Dioxide; Celite (R) 545; Crystalline Silica Quartz; Silica gel, ACS reagent; Celite(R) 512 medium; Kieselguhr, -325 mesh; Silica, 99.8%; SBA-15 Molecular Sieve; Silicon dioxide Nanopowder; Diatomaceous earth, powder; DSSTox_CID_9677; Silicon Dioxide Dispersion; Epitope ID:158537; Silica, fumed, hydrophobic; Silicon Dioxide Nanospheres; Silicon Dioxide, Amorphous; Silicon Oxide Nanoparticles; EC 231-545-4; Celite(R) 503, CP; Celite(R) 535, CP; Celite(R) 545, CP; Nano Silicon Dioxide Powder; DSSTox_RID_78805; CELATOM(R) FW-60; DSSTox_GSID_29677; Silicon dioxide, acid washed; Silica, hydrate(8CI,9CI); Silicon(IV) oxide (SiO2); 99439-28-8; Silicon Dioxide, Precipitated; Silica fibers, 1/4'' long; Kieselguhr, calcined, purified; Silica gel, CP, blue, beads; Silica Nanoparticles Dispersion; Silica, fused, respirable dust; 25wt% Silicon Oxide in Water; AW Standard Super-Cel(R) NF; MCM-41; Silica gel, CP, mixed, beads; Silica gel, CP, white, beads; Silicates (<1% crystalline silica):Graphite, natural; Hyflo(R) Super-Cel(R), CP; CHEMBL3188292; DTXSID1029677; Filter agent, Celite(R) 545; Sand, white quartz, CP, beads; Quarz cryst., 0.6-1.3 mm; Silicon dioxide, colloidal (NF); Diatomaceous earth, flux-calcined; Silicon dioxide, SAJ first grade; Diatomaceous earth non-washed, CP; Silica Gel Dessicant (Grade 03); Silica gel, CP, blue, bead size; Filter agent, Celatom(R) FW-14; Filter agent, Celatom(R) FW-50; Filter agent, Celatom(R) FW-60; Filter agent, Celatom(R) FW-80; Silica, fused [Silica, amorphous]; Silicon dioxide, JIS special grade; Silicon Oxide Mesoporous Nanopowder; AMY37125; Chromosorb(R) G, 80-100 mesh; 2-Mercaptoethyl ethyl sulfide silica; Celite(R) 545 AW, reagent grade; Silica gel 60, 230-400 mesh; Silica Hollow Nanospheres Dispersion; Silicon(IV) oxide, electronic grade; Tox21_301288; MFCD00148266; MFCD00603035; MFCD02100519; MFCD06202255; MFCD07370733; Sand, white quartz, CP, crystalline; Silica gel, indicating, 6-16 mesh; Chromosorb(R) W/AW, 45-60 mesh; Light anhydrous silicic acid (JP17); Quarz fine, cryst., 0.4-0.8 mm; Silica gel, 70-200 mesh (TLC); Silica, fumed, powder, 0.008 mum; AKOS009085429; Silicon Dioxide Nanospheres Properties; DB11132; Iron Sulfide (FeS) Sputtering Targets; Silicon Dioxide Nanoparticle Dispersion; Glass spheres, 9-13 mum particle size; Quartz (silicon dioxide), silver, pure; s25266; Silica gel, CP, white, medium granules; Silica gel, technical grade, 3-9 mesh; Silica, mesostructured, HMS (wormhole); NCGC00257531-01; Sand, white quartz, purum p.a., powder; Silica gel orange, granular, 0.2-1 mm; SILICON DIOXIDE amorphous fumed silica; Silicon Oxide Nanoparticles / Nanopowder; Silicon(IV) oxide, powder, 0.5 micron; Silicon(IV) oxide, powder, 1.0 micron; Silicon(IV) oxide, powder, 1.5 micron; 14639-89-5; 92283-58-4; E551; Silica gel, CP, blue, bead size, medium; Silica gel, technical grade, 6-16 mesh; Silicon oxide powder, 99% Nano, 20 nm; CAS-7631-86-9; Silica gel desiccant, -3+8 mesh granules; Silica gel, 12-24 mesh (liquid drying); Silica gel, CP, mixed, bead size, medium; Silica gel, for column chromatography, 60; Silicon Dioxide Nanoparticles / Nanopowder; Celite(R) 281, filter aid, flux calcined; Celite(R) S, filter aid, dried, untreated; Chromosorb(R) W/AW-DMCS, 80-100 mesh; Quarz min. 99% powdered, up to 125 m; Silica gel desiccant, -6+12 mesh granules; Silicon dioxide, purum p.a., acid purified; White Silica Gel Beads, 3 mm (2-5 mm); FT-0624621; FT-0645127; FT-0689145; FT-0689270; FT-0696592; FT-0696603; FT-0697331; FT-0697389; FT-0700917; Quartz rod, fused, 2.0mm (0.079in) dia; Quartz rod, fused, 5.0mm (0.197in) dia; S0822; Silica gel, with 1-4 mm moisture indicator; Silica, amorphous, fumed (crystalline free); Silicon dioxide Nanopowder KH550 processing; Silicon dioxide Nanopowder KH570 processing; Silicon(IV) oxide, 99.0% (metals basis); Celite(R) 110, filter aid, flux calcinated; Celite(R) 512 medium, filter aid, calcined; Chromosorb(R) G/AW-DMCS, 100-120 mesh; Chromosorb(R) W/AW-DMCS, 120-140 mesh; K-411 Glass microspheres, NIST SRM 2066; Quartz rod, fused, 10.0mm (0.394in) dia; Silica gel, technical grade 40, 6-12 mesh; C18 Silica Gel, Endcapped, 60A, 40-63um; D05839; D06521; D06522; D78143; Sand, white quartz, 50-70 mesh particle size; Silica gel, large pore, P.V. ca. 1.65cc/g; Silica, mesostructured, MSU-F (cellular f
• Drug Resistance Disease(s):
  Disease(s) with Resistance Information Validated by in-vivo Model for This Drug (2 diseases)
  Idiopathic interstitial pneumonitis [ICD-11: CB03]; [1]
  Pneumoconiosis [ICD-11: CA60]; [2]
• Target: .; NOUNIPROTAC; [2]
• IsoSMILES: O=[Si]=O
• InChI: InChI=1S/O2Si/c1-3-2
• InChIKey: VYPSYNLAJGMNEJ-UHFFFAOYSA-N
• PubChem CID: 24261
• DrugBank ID: DB11132

Type(s) of Resistant Mechanism of This Drug

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-12: Respiratory system diseases

Pneumoconiosis [ICD-11: CA60]

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Key Molecule: HOX transcript antisense RNA (HOTAIR) [2]

• Molecule Alteration: Up-regulation; Interaction
• Resistant Disease: Silicosis [ICD-11: CA60.0Z]
• Experimental Note: Discovered Using In-vivo Testing Model
• In Vitro Model: A549 cells; Lung; Homo sapiens (Human); CVCL_0023
• In Vitro Model: MRC-5 cells; Lung; Homo sapiens (Human); CVCL_0440
• In Vitro Model: NIH/3T3 cells; Whole embryo; Mus musculus (Mouse); CVCL_0594
• In Vitro Model: HBE cells; Bronchus; Homo sapiens (Human); CVCL_0287
• In Vivo Model: Silica-Induced lung Fibrosis mouse model; Lung Fibrosis MiR-326 overexpression mouse model; Mus musculus
• Experiment for Molecule Alteration: Western bloting analysis; Immunofluorescence assay; Knockdown assay
• Experiment for Drug Resistance: Dual luciferase reporter assays
• Mechanism Description: miR-326 Inhibits Inflammation and Promotes Autophagy in Silica-Induced Pulmonary Fibrosis through Targeting TNFSF14 and PTBP1.

Idiopathic interstitial pneumonitis [ICD-11: CB03]

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Key Molecule: Long non-protein coding RNA (CHRF) [1]

• Molecule Alteration: Up-regulation; Interaction
• Resistant Disease: Pulmonary fibrosis [ICD-11: CB03.1]
• Experimental Note: Discovered Using In-vivo Testing Model
• In Vitro Model: THP-1 cells; Blood; Homo sapiens (Human); CVCL_0006
• In Vitro Model: MRC-5 cells; Lung; Homo sapiens (Human); CVCL_0440
• In Vitro Model: RAW 264.7 cells; Ascites; Mus musculus (Mouse); CVCL_0493
• In Vitro Model: NIH/3T3 cells; Whole embryo; Mus musculus (Mouse); CVCL_0594
• In Vivo Model: Pulmonary fibrosis miR-489 overexpression mouse model; Mus musculus
• Experiment for Molecule Alteration: Overexpression assay
• Experiment for Drug Resistance: Immunofluorescence assay
• Mechanism Description: CHRF-miR-489-MyD88 Smad3 signaling axis exerts key functions in silica-induced pulmonary fibrosis and may represent a therapeutic target for silicosis.

References

• Ref 1: miR-489 inhibits silica-induced pulmonary fibrosis by targeting MyD88 and Smad3 and is negatively regulated by lncRNA CHRFSci Rep. 2016 Aug 10;6:30921. doi: 10.1038/srep30921.
• Ref 2: Andrographolide antagonizes the cigarette smoke-induced epithelial-mesenchymal transition and pulmonary dysfunction through anti-inflammatory inhibiting HOTAIRToxicology. 2019 Jun 15;422:84-94. doi: 10.1016/j.tox.2019.05.009. Epub 2019 May 23.