Molecule Information

General Information of the Molecule (ID: Mol02217)

• Name: Long non-protein coding RNA (GPX3-AS) ,Homo sapiens
• Synonyms: GPX3-AS
• Molecule Type: LncRNA
• Gene Name: GPX3-AS

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Hydrogen peroxide

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Age-related cataract [1]

• Resistant Disease: Age-related cataract [ICD-11: 9B10.0]
• Resistant Drug: Hydrogen peroxide
• Molecule Alteration: Down-regulation; Expression
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: HLECs; N.A.; Homo sapiens (Human); N.A.
• Experiment for Molecule Alteration: qRT-PCR; Western bloting analysis; Immunofluorescence assay; FISH assay
• Experiment for Drug Resistance: CCK8 assay; Flow cytometry assay
• Mechanism Description: GPX3-AS downregulated the apoptosis of LECs via promoting GPX3 expression, implying a novel therapeutic target for ARCs.

References

• Ref 1: Long noncoding RNA glutathione peroxidase 3-antisense inhibits lens epithelial cell apoptosis by upregulating glutathione peroxidase 3 expression in age-related cataractMol Vis. 2019 Nov 14;25:734-744. eCollection 2019.