Disease Information

General Information of the Disease (ID: DIS00396)

• Name: Cataract
• ICD: ICD-11: 9B10

Type(s) of Resistant Mechanism of This Disease

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Hydrogen peroxide

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Key Molecule: Long non-protein coding RNA (GPX3-AS) [1]

• Resistant Disease: Age-related cataract [ICD-11: 9B10.0]
• Molecule Alteration: Down-regulation; Expression
• Resistant Drug: Hydrogen peroxide
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: HLECs; N.A.; Homo sapiens (Human); N.A.
• Experiment for Molecule Alteration: qRT-PCR; Western bloting analysis; Immunofluorescence assay; FISH assay
• Experiment for Drug Resistance: CCK8 assay; Flow cytometry assay
• Mechanism Description: GPX3-AS downregulated the apoptosis of LECs via promoting GPX3 expression, implying a novel therapeutic target for ARCs.

Investigative Drug(s) 1 drug(s) in total

Tanshinone IIA

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Key Molecule: CDKN2B antisense RNA 1 (CDKN2B-AS1) [2]

• Resistant Disease: Age-related nuclear cataract [ICD-11: 9B10.0Y]
• Molecule Alteration: Up-regulation; Expression
• Resistant Drug: Tanshinone IIA
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: SRA01/04 cells; Eye; Homo sapiens (Human); CVCL_7157
• Experiment for Molecule Alteration: Mimic assay; qRT-PCR; Knockdown assay; Western bloting analysis
• Experiment for Drug Resistance: CCK8 assay; Flow cytometry assay; Carboxy-H2DCFDA assay
• Mechanism Description: Tanshinone IIA protects lens epithelial cells from H2 O 2 -induced injury by upregulation of LncRNA ANRIL.

References

• Ref 1: Long noncoding RNA glutathione peroxidase 3-antisense inhibits lens epithelial cell apoptosis by upregulating glutathione peroxidase 3 expression in age-related cataractMol Vis. 2019 Nov 14;25:734-744. eCollection 2019.
• Ref 2: Tanshinone IIA protects lens epithelial cells from H(2) O (2) -induced injury by upregulation of lncRNA ANRILJ Cell Physiol. 2019 Jan 30. doi: 10.1002/jcp.28189. Online ahead of print.