Molecule Information

General Information of the Molecule (ID: Mol02201)
Name
Urothelial cancer associated 1 (UCA1) ,Rattus norvegicus
Synonyms
UCA1
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Molecule Type
LncRNA
Gene Name
UCA1
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Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Rattus
Species: Rattus norvegicus
Type(s) of Resistant Mechanism of This Molecule
  EADR: Epigenetic Alteration of DNA, RNA or Protein
Drug Resistance Data Categorized by Drug
Investigative Drug(s)
1 drug(s) in total
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Kainic acid
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Epigenetic Alteration of DNA, RNA or Protein (EADR) Click to Show/Hide
Disease Class: Temporal lobe epilepsy [1]
Resistant Disease Temporal lobe epilepsy [ICD-11: 8A61.3Y]
 Disease Info 
Resistant Drug Kainic acid
 Drug Info 
Molecule Alteration Up-regulation
Expression
Experimental Note Identified from the Human Clinical Data
In Vivo Model Epileptic rats model Rattus norvegicus
Experiment for
Molecule Alteration		 qRT-PCR; Immunofluorescence assay; Western bloting analysis; Overexpression assay
Experiment for
Drug Resistance		 Morris water maze analysis
Mechanism Description LncRNA-UCA1 inhibits the astrocyte activation in the temporal lobe epilepsy via regulating the JAK/STAT signaling pathway.
References
Ref 1 LncRNA-UCA1 inhibits the astrocyte activation in the temporal lobe epilepsy via regulating the JAK/STAT signaling pathwayJ Cell Biochem. 2020 Oct;121(10):4261-4270. doi: 10.1002/jcb.29634. Epub 2020 Jan 7.

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