Molecule Information

General Information of the Molecule (ID: Mol02192)

• Name: LncRNA neighboring enhancer of FOXA2 (LNCNEF) ,Homo sapiens
• Synonyms: LNCNEF
• Molecule Type: LncRNA
• Gene Name: LNCNEF
• Gene ID: 101929685
• Location: chr20:22,587,522-22,607,517[-]
• Ensembl ID: ENSG00000237396
• HGNC ID: HGNC:50656

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Investigative Drug(s) 1 drug(s) in total

Wnt agonist

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Laryngeal carcinoma [1]

• Resistant Disease: Laryngeal carcinoma [ICD-11: 2C23.0]
• Resistant Drug: Wnt agonist
• Molecule Alteration: Down-regulation; Expression
• Experimental Note: Identified from the Human Clinical Data
• Cell Pathway Regulation: Wnt/Beta-catenin signaling pathway; Inhibition; hsa04310
• In Vitro Model: UM-SCC-17A cells; Larynx; Homo sapiens (Human); CVCL_7724
• Experiment for Molecule Alteration: qRT-PCR; Western bloting analysis; Overexpression assay
• Experiment for Drug Resistance: CCK8 assay
• Mechanism Description: Long non-coding RNA NEF inhibits proliferation and promotes apoptosis of laryngeal squamous cell carcinoma cells by inhibiting Wnt/beta-catenin signaling.

References

• Ref 1: Long non-coding RNA NEF inhibits proliferation and promotes apoptosis of laryngeal squamous cell carcinoma cells by inhibiting Wnt/Beta-catenin signalingOncol Lett. 2019 Jun;17(6):4928-4934. doi: 10.3892/ol.2019.10150. Epub 2019 Mar 15.