Drug Information

Drug (ID: DG01833) and It's Reported Resistant Information

Name	Wnt agonist
Synonyms	BML-284; Wnt Agonist; 853220-52-7; 2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine; N4-(1,3-benzodioxol-5-ylmethyl)-6-(3-methoxyphenyl)pyrimidine-2,4-diamine; 4-N-(1,3-benzodioxol-5-ylmethyl)-6-(3-methoxyphenyl)pyrimidine-2,4-diamine; N4-(Benzo[d][1,3]dioxol-5-ylmethyl)-6-(3-methoxyphenyl)pyrimidine-2,4-diamine; BML 284; 2-Amino-4-[3,4-(methylenedioxy)benzylamino]-6-(3-methoxyphenyl)pyrimidine; Wnt agonist 1;AMBMP; SCHEMBL430891; Wnt agonist 1(BML-284); Wnt agonist 1 (BML-284); CHEMBL4303671; BML 284;BML284; CHEBI:125559; BCP17186; EX-A2428; HSCI1_000334; NSC762367; ZINC44063027; CCG-208089; CS-5516; NSC-762367; NCGC00386697-01; NCGC00386697-05; AS-56297; HY-19987; C76745; BRD-K42624714-001-01-7; Q27216172; N4-[(2H-1,3-benzodioxol-5-yl)methyl]-6-(3-methoxyphenyl)pyrimidine-2,4-diamine; FW9 Click to Show/Hide
Structure
Drug Resistance Disease(s)	Disease(s) with Clinically Reported Resistance for This Drug (1 diseases) Laryngeal cancer [ICD-11: 2C23] [1]
Target	.	NOUNIPROTAC	[1]
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Formula	5
IsoSMILES	COC1=CC=CC(=C1)C2=CC(=NC(=N2)N)NCC3=CC4=C(C=C3)OCO4
InChI	InChI=1S/C19H18N4O3/c1-24-14-4-2-3-13(8-14)15-9-18(23-19(20)22-15)21-10-12-5-6-16-17(7-12)26-11-25-16/h2-9H,10-11H2,1H3,(H3,20,21,22,23)
InChIKey	FABQUVYDAXWUQP-UHFFFAOYSA-N
PubChem CID	11210285

Type(s) of Resistant Mechanism of This Drug

EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-02: Benign/in-situ/malignant neoplasm

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Laryngeal cancer [ICD-11: 2C23]

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Key Molecule: LncRNA neighboring enhancer of FOXA2 (LNCNEF)				[1]
Molecule Alteration	Down-regulation		Expression	Molecule Info
Resistant Disease	Laryngeal carcinoma [ICD-11: 2C23.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Cell Pathway Regulation	Wnt/Beta-catenin signaling pathway		Inhibition	hsa04310
In Vitro Model	UM-SCC-17A cells	Larynx	Homo sapiens (Human)	CVCL_7724
Experiment for Molecule Alteration	qRT-PCR; Western bloting analysis; Overexpression assay
Experiment for Drug Resistance	CCK8 assay
Mechanism Description	Long non-coding RNA NEF inhibits proliferation and promotes apoptosis of laryngeal squamous cell carcinoma cells by inhibiting Wnt/beta-catenin signaling.

References

Ref 1	Long non-coding RNA NEF inhibits proliferation and promotes apoptosis of laryngeal squamous cell carcinoma cells by inhibiting Wnt/Beta-catenin signalingOncol Lett. 2019 Jun;17(6):4928-4934. doi: 10.3892/ol.2019.10150. Epub 2019 Mar 15.