Molecule Information

General Information of the Molecule (ID: Mol02184)

Name	LMCD1 antisense RNA 1 (LMCD1-AS1) ,Homo sapiens
Synonyms	LMCD1-AS1 Click to Show/Hide
Molecule Type	LncRNA
Gene Name	LMCD1-AS1
Gene ID	100288428
Location	chr3:7,951,263-8,611,924[-]
Ensembl ID	ENSG00000227110
HGNC ID	HGNC:44477
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Investigative Drug(s)

1 drug(s) in total

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Aspirin CD3

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Disease Class: Cholangiocarcinoma				[1]
Resistant Disease	Cholangiocarcinoma [ICD-11: 2C12.0]			Disease Info
Resistant Drug	Aspirin CD3			Drug Info
Molecule Alteration	Down-regulation		Interaction
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Huh-7 cells	Liver	Homo sapiens (Human)	CVCL_0336
	HepG2 cells	Liver	Homo sapiens (Human)	CVCL_0027
In Vivo Model	Male BALB/c-nu/nu athymic nude mice model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR; Western bloting analysis; Luciferase assay; Immunofluorescence assay; ChIP assay; Immunohistochemistry analysis
Experiment for Drug Resistance	MTT assay
Mechanism Description	Aspirin targets P4HA2 through inhibiting NF-kappa-B and LMCD1-AS1/let-7g to inhibit tumour growth and collagen deposition in hepatocellular carcinoma.

Disease- and Tissue-specific Abundances of This Molecule

ICD Disease Classification 02

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Liver cancer [ICD-11: 2C12]

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Differential expression of molecule in resistant diseases
The Studied Tissue	Bile duct
The Specified Disease	Cholangiocarcinoma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 2.43E-02; Fold-change: -3.72E-01
Molecule expression in the diseased tissue of patients Molecule expression in the normal tissue of healthy individuals
Disease-specific Molecule Abundances		Click to View the Clearer Original Diagram
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The Studied Tissue	Liver
The Specified Disease	Liver hepatocellular carcinoma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 2.78E-03; Fold-change: -1.11E-01
Molecule expression in the diseased tissue of patients Molecule expression in the normal tissue of healthy individuals
Disease-specific Molecule Abundances		Click to View the Clearer Original Diagram
Download Molecule expression barchart for all samples Download Molecule expression data of patients in the disease section of the tissue Download Molecule expression data in the tissue of healthy individual

Tissue-specific Molecule Abundances in Healthy Individuals

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Download the Tissue-Specific Variation(s) Profile

References

Ref 1	Aspirin targets P4HA2 through inhibiting NF-kB and LMCD1-AS1/let-7g to inhibit tumour growth and collagen deposition in hepatocellular carcinomaEBioMedicine. 2019 Jul;45:168-180. doi: 10.1016/j.ebiom.2019.06.048. Epub 2019 Jul 2.