Drug Information

Drug (ID: DG01838) and It's Reported Resistant Information

Name	Aspirin CD3
Synonyms	Aspirin CD3; Acetylsalicylic acid-d3; 921943-73-9; Aspirin-d3; UNII-7F6Y89636M; Acetylsalicylic Acid;ASA; 2-(2,2,2-trideuterioacetyl)oxybenzoic acid; 7F6Y89636M; Trideuteriomethylaspirin; Benzoic acid, (acetyl-2,2,2-D3-oxy)-; [2H3]-Acetylsalicylic acid; 2-(Acetoxy-d3)benzoic acid; HY-14654S; MFCD09752106; CS-0214015; A935842; Acetylsalicylic acid-(methyl-d3), analytical standard; Q27268193 Click to Show/Hide
Structure
Drug Resistance Disease(s)	Disease(s) with Clinically Reported Resistance for This Drug (1 diseases) Liver cancer [ICD-11: 2C12] [1]
Target	.	NOUNIPROTAC	[1]
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Formula	3
IsoSMILES	[2H]C([2H])([2H])C(=O)OC1=CC=CC=C1C(=O)O
InChI	InChI=1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)/i1D3
InChIKey	BSYNRYMUTXBXSQ-FIBGUPNXSA-N
PubChem CID	12280114
DrugBank ID	DB00945

Type(s) of Resistant Mechanism of This Drug

EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-02: Benign/in-situ/malignant neoplasm

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Liver cancer [ICD-11: 2C12]

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Key Molecule: LMCD1 antisense RNA 1 (LMCD1-AS1)				[1]
Molecule Alteration	Down-regulation		Interaction	Molecule Info
Resistant Disease	Cholangiocarcinoma [ICD-11: 2C12.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Huh-7 cells	Liver	Homo sapiens (Human)	CVCL_0336
	HepG2 cells	Liver	Homo sapiens (Human)	CVCL_0027
In Vivo Model	Male BALB/c-nu/nu athymic nude mice model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR; Western bloting analysis; Luciferase assay; Immunofluorescence assay; ChIP assay; Immunohistochemistry analysis
Experiment for Drug Resistance	MTT assay
Mechanism Description	Aspirin targets P4HA2 through inhibiting NF-kappa-B and LMCD1-AS1/let-7g to inhibit tumour growth and collagen deposition in hepatocellular carcinoma.

References

Ref 1	Aspirin targets P4HA2 through inhibiting NF-kB and LMCD1-AS1/let-7g to inhibit tumour growth and collagen deposition in hepatocellular carcinomaEBioMedicine. 2019 Jul;45:168-180. doi: 10.1016/j.ebiom.2019.06.048. Epub 2019 Jul 2.